===== SIDA 1 ===== First 9 Months Earnings and Business Update November 14, 2024 ===== SIDA 2 ===== Disclaimer 2 This presentation (“Presentation”) does not contain or constitute an offer to sell, a solicitation of an offer to buy, or a recommendation to purchase any security of Alvotech (the “Company”) to any person in the United States or in any jurisdiction to whom or in which such offer or solicitation is unlawful. Any trademarks, servicemarks, trade names and copyrights of the Company and other companies contained in this Presentation are the property of their respective owners. Forward-Looking Statements This Presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements generally relate to future events or future financial or operating performance of the Company and may include, for example, the Company’s expectations regarding capitalization through equity or debt financing, Alvotech’s ability to maintain listing requirements, future growth, results of operations, performance, projections of future revenue and cash runway, competitive advantages, business prospects and opportunities including pipeline product development, future plans and intentions, results, level of activities, performance, goals or achievements or other future events, the re-inspection of the Company’s manufacturing site by the FDA, the expectation that the FDA’s facility inspection in March 2023 will also serve as the pre-license inspection for AVT04, potential approval, including for AVT02 and AVT04, by the FDA and other regulatory agencies, commercial launch of the Company’s products and product candidates, including AVT02 in the U.S., the timing and progress of the announcement of clinical study results, the commencement of patient studies, regulatory approvals and market launches, the Company’s partnerships, including with Teva and information about the market opportunity of the Company’s pipeline products. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by the Company and its management, are inherently uncertain and are inherently subject to risks, variability and contingencies, many of which are beyond the Company’s control. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: (1) the outcome of any legal proceedings that may be instituted against the Company or others following the business combination between Alvotech Holdings S.A., Oaktree Acquisition Corp. II and Alvotech; (2) the ability to maintain stock exchange listing standards; (3) changes in applicable laws or regulations; (4) the possibility that the Company may be adversely affected by other economic, business, and/or competitive factors; (5) the Company’s estimates of expenses and profitability; (6) the Company’s ability to develop, manufacture and commercialize the products and product candidates in its pipeline; (7) the ability of Alvotech or its partners to respond to inspection findings and resolve deficiencies to the satisfaction of the regulators; (8) actions of regulatory authorities, which may affect the initiation, timing and progress of clinical studies or future regulatory approvals or marketing authorizations; (9) the ability of the Company or its partners to enroll and retain patients in clinical studies; (10) the ability of the Company or its partners to gain approval from regulators for planned clinical studies, study plans or sites; (11) the ability of the Company’s partners to conduct, supervise and monitor existing and potential future clinical studies, which may impact development timelines and plans; (12) the Company’s ability to obtain and maintain regulatory approval or authorizations of its products, including the timing or likelihood of expansion into additional markets or geographies; (13) the success of the Company’s current and future collaborations, joint ventures, partnerships or licensing arrangements; (14) the Company’s ability, and that of its commercial partners, to execute their commercialization strategy for approved products; (15) the Company’s ability to manufacture sufficient commercial supply of its approved products; (16) the outcome of ongoing and future litigation regarding the Company’s products and product candidates; (17) the potential impact of the ongoing COVID-19 pandemic on the FDA’s review timelines, including its ability to complete timely inspection of manufacturing sites; and (18) the impact of worsening macroeconomic conditions, including rising inflation and interest rates and general market conditions, war in Ukraine and global geopolitical tension, and the ongoing and evolving COVID-19 pandemic on the Company’s business, financial position, strategy and anticipated milestones; and (19) other risks and uncertainties set forth in the sections entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements” in documents that the Company may from time to time file or furnish with the SEC. There may be additional risks that the Company does not presently know or that the Company currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. This presentation also contains estimates and other statistical data made by independent parties and by the Company relating to market size and growth and other data about the Company’s industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates. In addition, projections, assumptions, and estimates of the future performance of the markets in which the Company operates are necessarily subject to a high degree of uncertainty and risk. Nothing in this Presentation should be regarded as a representation by any person that the forward- looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. The Company does not undertake any duty to update these forward-looking statements or to inform the recipient of any matters of which any of them becomes aware of which may affect any matter referred to in this Presentation. Non-IFRS Financial Measures This Presentation may include projections of certain financial measures not presented in accordance with International Financial Reporting Standards (“IFRS”) including, but not limited to, Adjusted EBITDA and certain ratios and other metrics derived therefrom. These non-IFRS financial measures are not measures of financial performance in accordance with IFRS and may exclude items that are significant in understanding and assessing the Company’s financial results. Therefore, these measures should not be considered in isolation or as an alternative to net income, cash flows from operations or other measures of profitability, liquidity or performance under IFRS. You should be aware that the Company’s presentation of these measures may not be comparable to similarly-titled measures used by other companies. The Company believes these non- IFRS measures of financial results provide useful information to management and investors regarding certain financial and business trends relating to the Company’s financial condition and results of operations. The Company believes that the use of these non-IFRS financial measures provide an additional tool for investors to use in evaluating ongoing operating results and trends and in comparing the Company’s financial measures with other similar companies, many of which present similar non-IFRS financial measures to investors. These non-IFRS financial measures are subject to inherent limitations as they reflect the exercise of judgments by management about which expense and income are excluded or included in determining these non-IFRS financial measures. Due to the high variability and difficulty in making accurate forecasts and projections of some of the information excluded from these projected measures, together with some of the excluded information not being ascertainable or accessible, the Company is unable to quantify certain amounts that would be required to be included in the most directly comparable IFRS financial measures without unreasonable effort. Consequently, no disclosure of estimated comparable IFRS measures is included and no reconciliation of the forward-looking non-IFRS financial measures is included. For the same reasons, the Company is unable to address the probable significance of the unavailable information, which could be material to future results. ===== SIDA 3 ===== Agenda ROBERT WESSMAN Chairman and Chief Executive Officer ANIL OKAY Chief Commercial Officer JOEL MORALES Chief Financial Officer MING LI Chief Strategy Officer BENEDIKT STEFÁNSSON VP of IR and Global Communication 1 2 3 4 OVERVIEW COMMERCIAL and R&D UPDATE FINANCIAL UPDATE Q&A ===== SIDA 4 ===== Robert Wessman Chairman and Chief Executive Officer ===== SIDA 5 ===== Continued Growth for 2024 5 Key Financial Highlights 9M-2024 Positive Adjusted EBITDA for the 2nd consecutive quarter, resulting in a total of $86.6mn for 9M-24 → ~9x increase in revenues vs. prior year → Step up product gross margin in Q3 (37%) vs. Q2 (17%)1 → Pipeline progression and new deals resulted in increased milestone revenue recognition Product Revenues 9M - 2024 Performance Total Revenues Milestone Revenues Adjusted EBITDA $338.6mn $128.0mn $86.6mn $210.5mn vs. $38.1mn in 9M-23 vs. $29.8mn in 9M-23 vs. ($225.3mn) loss in 9M-23 vs. 8.2mn in 9M-23 1Excludes margin contribution from milestone revenues ===== SIDA 6 ===== Key Recent Highlights 6 EMA acceptance of marketing application for AVT03, biosimilar to Prolia® and Xgeva® SELARSDI® full label and additional presentation approved Patient Study for AVT16, proposed biosimilar to Entyvio® , has been initiated EMA acceptance of marketing application for AVT05, biosimilar to Simponi® U.S. FDA concluded a successful general GMP inspection in September of Alvotech’s Reykjavik manufacturing site → 2 FDA 483 observations were noted; company has provided robust responses ===== SIDA 7 ===== Launch of UZPRUVO® Approval of UZPRUVO® Positive clinical study results for AVT06 Initial launch of SIMLANDI® Approval of SIMLANDI® Approval of SELARSDI® US Commercial agreement with QUALLENT Collaboration with STADA for AVT03 Collaboration with Advanz for AVT06 Launch of JAMTEKI 7 Continued Progress and Execution (2024) Clarity for market entry dates for AVT04 Positive clinical study results for AVT05 Launch of USTEKINUMAB Positive PK Study for AVT03 Collaboration with Dr. Reddy’s for AVT03 Closing of private debt financing ALVOTECH 7 JANUARY MARCH APRILFEBRUARY JUNEMAY Positive clinical study results for AVT03 EMA filing acceptance of AVT06 Successful GMP Inspection FDA Confirmatory Patient Study for AVT16 EMA MA Acceptance AVT03 Positive clinical study results for AVT03 Full label and additional presentation approved on SELARSDI® JULY SEPTEMBER OCTOBERAUGUST NOVEMBER DECEMBER EMA MA Acceptance AVT05 ===== SIDA 8 ===== Anil Okay Chief Commercial Officer ===== SIDA 9 ===== U.S. Commercialization Update 9 Biosimilar to Stelara® SELARSDI® approved in the U.S. for all associated indications Product launch expected to be February 21, 2025 February 19th, 2025, BSUFA date to determine interchangeability Provisional approval is expected with final approval given upon exclusivity expiry on April 30, 2025 Ongoing discussions for formulary access through commercial partner Teva Ongoing discussions for private label business Biosimilar to Humira® SIMLANDI® and unbranded form are interchangeable to the reference product SIMLANDI® is listed as preferred on Express Scripts (part of CIGNA), CarelonRx, Navitus, Blue Cross Blue Shield of MA and LA; expect expansion in 2025 Commercialization agreement with Quallent; part of the Cigna network ~1.3 million units of binding purchase orders for 2024 across both channels (US only) >40% of orders delivered through Q3 ===== SIDA 10 ===== Ex-US Commercialization Update 10 AVT02, biosimilar to Humira® , has been launched in 26 markets outside the U.S. • Inclusive of Canada (SIMLANDI®) and many markets across Europe (HUKYNDRA®) AVT04, biosimilar to Stelara, has been launched in 23 markets • Inclusive of Canada (JAMTEKI ), Japan, and across Europe (UZPRUVO®) UZPRUVO® launched in ~20 markets across Europe with further expansion expected in the coming months • Strong partner sales in EU4 plus UK Up to 1/3 of product revenue in 20241 expected to come from ex-US markets Growth in product revenue expected in 2025 from ex-US markets from both new and existing launches 1Inclusive of both AVT02 and AVT04 ===== SIDA 11 ===== Near Term Pipeline Update 11 Biosimilar candidate to Eylea® Developing for both vial and pre-filled syringe Seeking interchangeability designation Partnerships include Teva (US), Advanz (EU) Marketing application accepted by EMA IP strategy integrated with product development AVT29 Biosimilar candidate to Eylea® HD Commercial partnerships consistent with low-dose Formulation and process have been developed and program currently in scale- up phase IP strategy integrated with product development AVT06 11 ===== SIDA 12 ===== Near Term Pipeline Update 12 Targeting both Simponi® (pharmacy benefit) and Simponi Aria® (medical benefit) Established anti-TNF with SP2/0 technology barrier Only one other company has completed a clinical trial utilizing a biosimilar candidate Marketing application accepted by EMA; the first and currently only filing1 US filing expected in 20242 via 2 separate submissions 12 AVT05 AVT03 Biosimilar candidate to Prolia® and Xgeva® Both a Medical benefit and pharmacy benefit product in the U.S. US Partnership with Dr. Reddy’s Laboratories Semi-exclusive partnership in EU with Dr. Reddy’s and STADA Marketing application accepted by EMA US filing expected in 20241 1EMA Oct 2024 list of medicines under evaluation 2Announcements are made upon filing acceptance ===== SIDA 13 ===== Portfolio 13 BIOSIMILAR CANDIDATE REFERENCE BIOLOGIC THERAPEUTIC AREA EARLY PHASE PRE- CLINICAL CLINICAL TRIAL(S) FILING2 APPROVAL LAUNCH PK STUDY PATIENT TRIAL AVT02 adalimumab HUMIRA® Immunology AVT04 ustekinumab STELARA® Immunology AVT05 golimumab SIMPONI®/ SIMPONI ARIA® Ophthalmology AVT03 denosumab PROLIA®/ XGEVA® Bone Disease AVT061 aflibercept EYLEA® Immunology AVT29 aflibercept EYLEA® HD Ophthalmology AVT233 omalizumab XOLAIR® Respiratory AVT16 vedolizumab ENTYVIO® Immunology AVT33 pembrolizumab KEYTRUDA® Oncology AVT28 Not disclosed Not disclosed Immunology AVT41 Not disclosed Not disclosed Immunology AVT19 Not disclosed Not disclosed Immunology 27 Markets 23 Markets 58 Markets 42 Markets 73 Markets 52 Markets 1Separate PK studies are not required for proposed biosimilars to Eylea® 2Filing status reflects filing acceptance in at least one major market 3AVT23 rights are licensed from Kashiv BioSciences and refer specifically to European Union member states, the UK, Australia, Canada, and New Zealand. Positive Results Ongoing Ongoing Positive Results Positive Results Positive Results EYLEA is a registered trademark of Regeneron Pharmaceuticals, Inc. ENTYVIO is a registered trademark of Millennium Pharmaceuticals, Inc. KEYTRUDA is a registered trademark of Merck Sharp & Dohme Corp. HUMIRA is a registered trademark of AbbVie Inc. STELARA, SIMPONI and SIMPONI ARIA are registered trademarks of Johnson & Johnson Inc. XOLAIR is a registered trademark of Novartis AG PROLIA AND XGEVA are registered trademarks of Amgen, Inc. ===== SIDA 14 ===== Joel Morales Chief Financial Officer ===== SIDA 15 ===== Q3 2024 YTD Financial Highlights 15 CASH AND LIQUIDITY OPERATING PERFORMANCE SHARES OUTSTANDING Finalized financing facilities in Q3, simplifying overall capital structure – as of 30 September, ~$1B of outstanding borrowings. $118 million of cash on hand as of 30 September. Based on current operating plans, the Company believes it has sufficient cash runway to free cash flow positive. 301.7 million shares outstanding as of 30 September. Includes 39.6 million of earnout shares, of which 19.2 million not currently vested. Excludes shares to be issued for certain programs and arrangements that are not yet settled as of 30 September. Total revenue of $339 million, ~ 9x increase versus prior year. $128 million of product revenues primarily driven by Humira biosimilar launch in US and Stelara biosimilar launch in ex- US markets. $211 million of milestone revenue, primarily due to advancement of the pipeline and new product launches. Adjusted EBITDA of $87 million, versus negative ($225) million in prior year. ===== SIDA 16 ===== Appendix ===== SIDA 17 ===== Reported to Adjusted Reconciliation 17 9M 2024 Adjustment Entries Cost of Product Revenue − $1.2m charge related to long-term incentive plan R&D − $1.9m charge related to long-term incentive plan (non-cash) − ($1.3m) IP litigation costs attributable to programs - reclassified from G&A − ($1.1m) partial reversal of one-time AR reserve pertaining to the termination of AVT23 licensing agreement with Biosana (non -cash) G&A − $4.8m charge related to long-term incentive plan (non-cash) − $1.3m IP litigation costs attributable to programs - reclassified to R&D − $0.5m one-time transaction cost Impairment loss on inv. in JV − $3.0m from sales of China JV Finance Income − ($75.5m) fair value adjustment on derivatives (non-cash) Finance Costs − $117.5m fair value adjustment on derivatives (non-cash) (Loss) Gain on exting. of fin. liab. − $69.4m loss on extinguishment of bonds and borrowings (non-cash) Exchange Rate Differences − ($1.7m) impact of exchange rate fluctuations (non-cash) Income Tax − ($0.8m) tax impact of discrete adj. in jurisdictions where tax benefits are available 9M 2023 Adjustment Entries Cost of Product Revenue − $2.3m charge related to long-term incentive plan − $0.3m loss on disposal of PPE (non -cash) R&D − $18.5m of one-time, Biosana accounts receivables reserve pertaining to the termination of AVT-23 (non-cash) − $3.5m charge related to long-term incentive plan (non-cash) − ($1.9m) IP litigation costs attributable to programs - reclassified from G&A G&A − $0.9m of one-time costs in connection with the Iceland main board listing − $9.4m charge related to long-term incentive plan (non-cash) − $1.9m IP litigation costs attributable to programs – reclassified to R&D Finance Income − ($42.5m) fair value adjustment on derivatives (non-cash) Finance Cost − $14.1m fair value adjustment on derivatives (non-cash) Exchange Rate Differences − ($0.9m) impact of exchange rate fluctuations (non-cash) Income Tax − ($3.7m) tax impact of discrete adj. in jurisdictions where tax benefits are available ===== SIDA 18 ===== Capital Structure as of September 30, 2024 18 1 Using the Company's average stock price of $11.07 and calculated in accordance with the Warrant Agreement dated September 21, 2020. ===== SIDA 19 ===== Additional information investors.alvotech.com investors.alvotech.com alvotech.com alvotech.com alvotech.is alvotech.is alvotech.ir@alvotech.com alvotech.ir@alvotech.com