===== SIDA 1 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 1 10 February 2026 AstraZeneca results: FY and Q4 2025 Strong commercial performance and excellent pipeline delivery in a continuing catalyst-rich period Revenue and EPS summary FY 2025 % Change Q4 2025 % Change $m Actual CER1 $m Actual CER - Product Sales 55,573 9 9 14,538 9 7 - Alliance Revenue 3,067 39 38 959 34 33 Product Revenue2 58,640 10 10 15,497 10 8 Collaboration Revenue 99 (89) (89) 6 (99) (99) Total Revenue 58,739 9 8 15,503 4 2 Reported EPS ($) 6.60 45 43 1.50 55 47 Core3 EPS ($) 9.16 12 11 2.12 1 (2) Key performance elements for FY 2025 (Growth numbers at constant exchange rates)  Total Revenue up 8% to $58,739m, driven by Oncology, CVRM, R&I and Rare Disease  Growth in Total Revenue across all major geographic regions  Core Operating profit increased 9%  Core EPS increased 11% to $9.16  Second interim dividend declared of $2.17 per share (159.5 pence, 19.49 SEK). Total dividend declared for FY 2025 increased by 3% to $3.20 per share  16 positive Phase 3 readouts and 43 approvals in major regions in the last twelve months Pascal Soriot, Chief Executive Officer, AstraZeneca, said: “In 2025 we saw strong commercial performance across our therapy areas and excellent pipeline delivery. We announced the results of 16 positive Phase 3 studies during the year and now have 16 blockbuster medicines. The momentum across our company is continuing in 2026 and we are looking forward to the results of more than 20 Phase 3 trial readouts this year. We have more than 100 Phase 3 studies ongoing, including a substantial and growing number of trials of our transformative technologies which have the potential to revolutionise outcomes for patients and drive our growth well beyond 2030. Lastly, ordinary shares in our company began trading on the NYSE on the 2nd February, resulting in a harmonised listing structure across exchanges in London, New York and Stockholm, enabling more shareholders to participate in our company’s exciting future.” Guidance AstraZeneca issues Total Revenue and Core EPS guidance4 for FY 2026 at CER, based on the average foreign exchange rates through 2025. Total Revenue is expected to increase by a mid-to-high single-digit percentage Core EPS is expected to increase by a low double-digit percentage The Core Tax rate is expected to be between 18-22% If foreign exchange rates for February 2026 to December 2026 were to remain at the average rates seen in January 2026, it is anticipated that Total Revenue in FY 2026 would benefit from a low single-digit percentage positive impact compared to the performance at CER, and Core EPS growth would be broadly similar to the growth at CER. ===== SIDA 2 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 2 Navigation tips The text in this contents page, and in the header at the top of every page, are hyperlinked – click one to navigate to a section or table. To return to the previous location after clicking a hyperlink, press + (Windows) or + (macOS) Example: - To see the definition of an acronym, click on ‘Glossary’ at the top right of the page. - After viewing the definition, press + or + to return to your previous location. Contents Results highlights ...................................................................................................................................................................................... 3 Revenue drivers ........................................................................................................................................................................................ 7 R&D progress .......................................................................................................................................................................................... 13 Sustainability .......................................................................................................................................................................................... 16 Operating and financial review............................................................................................................................................................... 17 Financial performance ............................................................................................................................................................................ 18 Condensed consolidated financial statements ....................................................................................................................................... 23 Notes to the Condensed consolidated financial statements .................................................................................................................. 28 Other shareholder information .............................................................................................................................................................. 37 Glossary .................................................................................................................................................................................................. 39 Tables Table 1: Milestones achieved since the prior results announcement ...................................................................................................... 3 Table 2: Key elements of financial performance: Q4 2025 ...................................................................................................................... 4 Table 3: Product Revenue by medicine .................................................................................................................................................... 7 Table 4: Collaboration Revenue ............................................................................................................................................................... 8 Table 5: Total Revenue by Therapy Area .................................................................................................................................................. 8 Table 6: Total Revenue by region ............................................................................................................................................................. 8 Table 7: Product Revenue by region ......................................................................................................................................................... 8 Table 8: Reported Profit and Loss........................................................................................................................................................... 18 Table 9: Reconciliation of Reported Profit before tax to EBITDA ........................................................................................................... 18 Table 10: Reconciliation of Reported to Core financial measures: FY 2025 ........................................................................................... 18 Table 11: Reconciliation of Reported to Core financial measures: Q4 2025 .......................................................................................... 19 Table 12: Cash Flow summary: FY 2025 ................................................................................................................................................. 20 Table 13: Net debt summary .................................................................................................................................................................. 20 Table 14: Obligor group summarised Statement of comprehensive income: FY 2025 .......................................................................... 21 Table 15: Obligor group summarised Statement of financial position ................................................................................................... 21 Table 16: Currency sensitivities .............................................................................................................................................................. 22 Table 17: Condensed consolidated statement of comprehensive income: FY 2025 .............................................................................. 23 Table 18: Condensed consolidated statement of comprehensive income: Q4 2025 ............................................................................. 24 Table 19: Condensed consolidated statement of financial position....................................................................................................... 25 Table 20: Condensed consolidated statement of changes in equity ...................................................................................................... 26 Table 21: Condensed consolidated statement of cash flows: FY 2025 ................................................................................................... 27 Table 22: Net debt .................................................................................................................................................................................. 29 Table 23: Contingent consideration ....................................................................................................................................................... 30 Table 24: Patent litigation ...................................................................................................................................................................... 31 Table 25: Product liability litigation ........................................................................................................................................................ 32 Table 26: Commercial litigation .............................................................................................................................................................. 32 Table 27: Government investigations and proceedings ......................................................................................................................... 33 Table 28: Product Sales year-on-year analysis: FY 2025 ......................................................................................................................... 34 Table 29: Product Sales year-on-year analysis: Q4 2025 ........................................................................................................................ 35 Table 30: Alliance Revenue: FY 2025 ...................................................................................................................................................... 36 Table 31: Collaboration Revenue: FY 2025 ............................................................................................................................................. 36 Table 32: Other operating income and expense: FY 2025 ...................................................................................................................... 36 ===== SIDA 3 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 3 Table 1: Milestones achieved since the prior results announcement Phase III and other registrational data readouts Medicine Trial Indication Event ceralasertib + Imfinzi LATIFY Post-IO NSCLC Primary endpoint not met baxdrostat BaxAsia Treatment resistant hypertension Primary endpoint met Regulatory approvals Medicine Trial Indication Region Enhertu DESTINY-Gastric04 2L HER2+ gastric/GEJ cancer EU, CN Enhertu DESTINY-Breast09 1L HER2+ mBC US Enhertu DESTINY-Breast06 CTx naïve HER2-low and -ultralow mBC CN Imfinzi PACIFIC-5 Stage III NSCLC CN Imfinzi MATTERHORN Resectable gastric/GEJ cancer US Imfinzi DUO-E dMMR endometrial cancer CN Wainua NEURO- TTRANSFORM ATTRv-PN CN Fasenra MANDARA EGPA CN Saphnelo TULIP-SC SLE (subcutaneous) EU Koselugo KOMET Adult patients with NF1-PN US Koselugo SPRINKLE Paediatric patients with NF1-PN (granule formulation) EU Soliris NCT03759366 gMG (paediatric patients) CN Regulatory submissions or acceptances* in major regions Medicine Trial Indication Region Datroway TROPION-Breast02 Metastatic TNBC not candidates for IO US, EU, CN Enhertu DESTINY-Breast09 1L HER2+ mBC EU Ultomiris ALXN1210-PNH-323 PNH CN baxdrostat BaxHTN / Bax24 Treatment resistant hypertension US, EU gefurulimab PREVAIL Generalised myasthenia gravis US, EU, CN anselamimab CARES Kappa light chain amyloidosis EU, JP * US, EU and China regulatory submissions denotes filing acceptance Other pipeline updates For recent trial starts and anticipated timings of key trial readouts, please refer to the Clinical Trials Appendix document in the financial results section of the AstraZeneca investor relations website: www.astrazeneca.com/investor-relations.html. Results highlights ===== SIDA 4 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 4 Table 2: Key elements of financial performance: Q4 2025 For the quarter Reported Change Core Change ended 31 December $m Act CER $m Act CER Product Revenue 15,497 10 8 15,497 10 8  See Tables 3, 7, 29 and 30 for further details of Product Revenue, Product Sales and Alliance Revenue Collaboration Revenue 6 (99) (99) 6 (99) (99)  See Tables 4 and 31 for details of Collaboration Revenue  In Q4 2024, $815m of Collaboration Revenue was recognised as Lynparza, Beyfortus and Koselugo each achieved a sales-based milestone Total Revenue 15,503 4 2 15,503 4 2  See Tables 5 and 6 for Total Revenue by Therapy Area and by region Gross Margin (%) 80 -2pp -2pp 80 -2pp -2pp − Cost of sales included a $235m expense in Q4 2025 for royalty buyout expenses relating to Saphnelo and rilvegostomig (see page 5, ‘Corporate and business development’ for details)  Variations in Gross Margin can be expected between periods due to various factors, including fluctuations in foreign exchange rates, product seasonality and Collaboration Revenue  See ‘Reporting changes since FY 2024’ on page 6 for the definition of Gross Margin5 R&D expense 3,862 (17) (19) 3,731 4 3  Core R&D: 24% of Total Revenue + Accelerated recruitment in ongoing trials + Investments in transformative technologies such as IO bispecifics, cell therapy and antibody drug conjugates + Addition of R&D projects from business development + Positive data readouts for high value pipeline opportunities that have ungated large late-stage trials − Reported R&D expense decreased due to impairment charges in Q4 2024 SG&A expense 5,492 2 - 4,453 4 2  Core SG&A: 29% of Total Revenue Other operating income and expense6 100 - 2 101 2 2 Operating Profit 2,978 46 40 4,098 (2) (5) − Operating Profit includes the $235m royalty buyout expensed in Cost of sales (see above) + Reported Operating Profit includes R&D impairment charges in Q4 2024 Operating Margin (%) 19 +6pp +5pp 26 -2pp -2pp Net finance expense 349 (4) (2) 269 (13) (10) − Adjustment of interest on tax and maturity of debt during Q4 2025 Tax rate (%) 11 +1pp +1pp 14 -2pp -2pp  Variations in the tax rate can be expected between periods EPS ($) 1.50 55 47 2.12 1 (2) − Year-on-year comparison reflects the sales-based milestones recognised in Q4 2024 + Reported EPS benefitted from reduction in R&D impairments For monetary values the unit of change is percent. For Gross Margin, Operating Margin and Tax rate, the unit of change is percentage points (pp). In the expense commentary above, the plus and minus symbols denote the directional impact of the item being discussed, e.g. a ‘+’ symbol beside an R&D expense comment indicates that the item increased R&D expenditure relative to the prior year period. ===== SIDA 5 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 5 Corporate and business development Jacobio Pharma In December 2025, Jacobio Pharma announced that it has entered an agreement with AstraZeneca for its proprietary Pan-KRAS inhibitor JAB-23E73. AstraZeneca will receive exclusive development and commercialisation rights outside of China, while AstraZeneca and Jacobio Pharma will jointly develop and commercialise JAB-23E73 in China. Under the terms of the agreement, Jacobio will receive an upfront payment of $100m, and is eligible for additional development and commercial milestone payments of up to $1.9bn, as well as tiered royalties on net sales achieved outside of China. AstraZeneca will be responsible for all clinical development, regulatory submissions, and commercialisation activities for JAB-23E73 outside of China. Modella AI In Q4 2025, Modella AI was acquired by AstraZeneca. The acquisition will embed Modella AI’s multi-modal foundation models and AI agents into AstraZeneca’s oncology R&D environment. BMS In Q4 2025, AstraZeneca paid Bristol- Myers Squibb Company (BMS) $170m, expensed in Cost of sales, in exchange for the reduction to zero of all royalties payable on Saphnelo sales ex-US. Royalties on US sales will remain payable at a mid- teens percentage. Compugen In Q4 2025, AstraZeneca paid Compugen Ltd. (Compugen) $65m, expensed in Cost of sales, and agreed a potential additional $25m upon the next milestone payment on BLA acceptance, for a portion of Compugen's existing royalty interest in rilvegostomig. AstraZeneca will pay tiered royalties of up to mid-single digits on future sales. AbelZeta In January 2026, AbelZeta Pharma, Inc. (AbelZeta) announced that AstraZeneca has agreed to acquire AbelZeta’s 50% share of the China development and commercialisation rights to C-CAR031, an autologous, Glypican 3 (GPC3)-targeting chimeric antigen receptor T-Cell therapy. Following completion of this agreement, AstraZeneca will have the sole right to develop, manufacture and commercialise C-CAR031 globally. AbelZeta will be entitled to receive up to $630m from AstraZeneca including an upfront payment, and development, regulatory and sales milestone payments for the GPC3 program in China. China investment plans In January 2026, AstraZeneca announced plans to invest $15bn in China through 2030 to expand medicines manufacturing and R&D. These investments build on AstraZeneca’s substantial footprint in China, including global strategic R&D centres in Beijing and Shanghai. Listing harmonisation On 2 February 2026, AstraZeneca began trading its ordinary shares on the New York Stock Exchange (NYSE), enabling more US investors to participate in the Company’s strong growth. Trading in AstraZeneca ordinary shares is now aligned across the NYSE, the London Stock Exchange and Nasdaq Stockholm under a harmonised listing structure. The prior listing of American Depositary Shares on Nasdaq in the US ceased on 30 January 2026. CSPC In January 2026, AstraZeneca announced a new strategic collaboration agreement with CSPC Pharmaceuticals. AstraZeneca will receive exclusive global rights outside of China to CSPC's once-monthly injectable weight management portfolio, including SYH2082, a long-acting GLP-1R/GIPR agonist progressing into Phase I, and three preclinical programmes. CSPC will receive an upfront payment of $1.2bn and is eligible to receive development and regulatory milestones of up to $3.5bn across all programmes. CSPC will also be eligible for further commercialisation and sales milestones plus tiered royalties. Sustainability highlights For the tenth year, AstraZeneca was recognised by CDP for climate action and water stewardship, receiving an A for Climate and A– for Water Security in 2025. This reflects the Company’s significant progress in decarbonising and reducing its environmental footprint. The Sustainable Markets Initiative (SMI) Health Systems Task Force, chaired by AstraZeneca CEO Pascal Soriot, supported the development and launch of PSA 2090, the world’s first global standard to measure and assess the environmental impact of pharmaceutical products through their lifecycle. Reporting calendar The Company intends to publish its Q1 2026 results on 29 April 2026. Conference call A conference call and webcast for investors and analysts will begin today, 10 February 2026, at 11:45 UK time. Details can be accessed via astrazeneca.com. ===== SIDA 6 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 6 Reporting changes since FY 2024 Product Revenue Effective 1 January 2025, the Group has updated the presentation of Total Revenue on the face of the Statement of Comprehensive Income to include a new subtotal ‘Product Revenue’ representing the summation of Product Sales and Alliance Revenue. Product Revenue and Collaboration Revenue form Total Revenue. Product Sales and Alliance Revenue will continue to be presented separately, with the new subtotal providing additional aggregation of revenue types with similar characteristics, reflecting the growing importance of Alliance Revenue. Full descriptions of Product Sales, Alliance Revenue and Collaboration Revenue are included from page 152 of the Group's Annual Report and Form 20-F Information 2024. Gross Margin Effective 1 January 2025, the Group has replaced the measure of ‘Product Sales Gross Margin’ with the measure of ‘Gross Margin’. Previously, the measure excluded margin related to Alliance Revenue and Collaboration Revenue. The new measure is calculated using Gross profit as a percentage of Total Revenue, thereby encompassing all revenue categories, and is intended to provide a more comprehensive measure of total performance. Notes 1. Constant exchange rates. The differences between Actual Change and CER Change are due to foreign exchange movements between periods in 2025 vs. 2024. CER financial measures are not accounted for according to generally accepted accounting principles (GAAP) because they remove the effects of currency movements from Reported results. 2. Effective 1 January 2025, the Group has updated its presentation of Total Revenue, adding a new subtotal of Product Revenue, the sum of Product Sales and Alliance Revenue. For further details, see Note 1: ‘Basis of preparation and accounting policies’ in the Notes to the Condensed consolidated financial statements. 3. Core financial measures are adjusted to exclude certain items. The differences between Reported and Core measures are primarily due to costs relating to the amortisation of intangibles, impairments, legal settlements and restructuring charges. A full reconciliation between Reported EPS and Core EPS is provided in Tables 10 and 11 in the Financial Performance section of this document. 4. The Company is unable to provide guidance on a Reported basis because it cannot reliably forecast material elements of the Reported results, including any fair value adjustments arising on acquisition-related liabilities, intangible asset impairment charges and legal settlement provisions. Please refer to the Cautionary statements section regarding forward-looking statements at the end of this announcement. 5. Effective 1 January 2025, the Group has updated its presentation of Gross Margin, which is defined as Gross Profit divided by Total Revenue. In prior years, the Group’s financial tables cited a different margin metric, Product Sales Gross Margin. 6. Income from disposals of assets and businesses, where the Group does not retain a significant ongoing economic interest, is recorded in Other operating income and expense in the Group’s financial statements. ===== SIDA 7 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 7 Table 3: Product Revenue by medicine FY 2025 % Change Q4 2025 % Change $m % Total Actual CER $m % Total Actual CER Tagrisso 7,254 12 10 10 1,902 12 12 10 Imfinzi 6,063 10 29 28 1,747 11 39 37 Calquence 3,518 6 12 12 967 6 20 17 Lynparza 3,279 6 7 6 878 6 4 1 Enhertu 2,775 5 40 40 798 5 48 46 Zoladex 1,150 2 5 6 266 2 5 5 Truqap 728 1 69 68 233 2 43 41 Imjudo 346 1 23 23 93 1 27 26 Datroway 78 - n/m n/m 40 - n/m n/m Other Oncology 427 1 (8) (8) 103 1 (4) (3) Oncology Product Revenue 25,618 44 18 17 7,027 45 22 20 Farxiga 8,405 14 10 9 2,060 13 7 2 Crestor 1,218 2 5 6 276 2 6 6 Brilinta 823 1 (38) (38) 158 1 (54) (54) Lokelma 698 1 29 28 181 1 21 19 Seloken 608 1 - 2 139 1 (1) (1) roxadustat 276 - (18) (18) 47 - (37) (37) Wainua 212 - >2x >2x 69 - 66 64 Other CVRM 534 1 (28) (28) 116 1 (39) (40) CVRM Product Revenue 12,774 22 3 2 3,046 20 (3) (6) Symbicort 2,885 5 - - 704 5 3 2 Fasenra 1,981 3 17 16 530 3 12 10 Breztri 1,199 2 23 22 294 2 14 13 Tezspire 1,131 2 65 64 361 2 69 66 Saphnelo 686 1 45 44 203 1 38 37 Pulmicort 518 1 (24) (24) 161 1 (2) (6) Airsupra 166 - >2x >2x 51 - >2x >2x Other R&I 300 1 (29) (29) 69 - (58) (59) R&I Product Revenue 8,866 15 13 12 2,373 15 12 10 Beyfortus 703 1 27 26 229 1 (21) (22) Synagis 292 - (35) (34) 72 - (29) (31) FluMist 272 - 6 3 140 1 (6) (9) Other V&I 1 - n/m n/m 1 - n/m n/m V&I Product Revenue 1,268 2 (2) (3) 442 3 (18) (19) Ultomiris 4,718 8 20 19 1,265 8 16 15 Soliris 1,837 3 (29) (28) 401 3 (26) (26) Strensiq 1,678 3 19 18 490 3 17 15 Koselugo 662 1 25 22 163 1 (1) (4) Other Rare Disease 231 - 11 10 55 - (9) (11) Rare Disease Product Revenue 9,126 16 5 5 2,374 15 4 3 Nexium 831 1 (6) (5) 193 1 (4) (4) Others 157 - (25) (25) 42 - (22) (21) Other Medicines Product Revenue 988 2 (10) (9) 235 2 (8) (8) Product Revenue 58,640 100 10 10 15,497 100 10 8 Alliance Revenue included above: Enhertu 1,798 3 25 25 507 3 29 27 Tezspire 673 1 54 54 220 1 65 64 Beyfortus 422 1 79 76 170 1 6 6 Datroway 77 - n/m n/m 39 - n/m n/m Other royalty income 92 - 1 1 22 - (6) (7) Other Alliance Revenue 5 - (53) (53) 1 - (65) (65) Alliance Revenue 3,067 5 39 38 959 6 34 33 Revenue drivers ===== SIDA 8 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 8 Table 4: Collaboration Revenue FY 2025 % Change Q4 2025 % Change $m Actual CER $m Actual CER Farxiga: sales milestones 87 56 56 6 50 41 Others 12 (99) (99) - n/m n/m Collaboration Revenue 99 (89) (89) 6 (99) (99) Table 5: Total Revenue by Therapy Area FY 2025 % Change Q4 2025 % Change $m % Total Actual CER $m % Total Actual CER Oncology 25,619 44 15 14 7,028 45 11 9 CVRM 12,861 22 3 2 3,051 20 (3) (6) R&I 8,866 15 13 12 2,373 15 12 10 V&I 1,268 2 (13) (14) 442 3 (32) (33) BioPharmaceuticals 22,995 39 5 5 5,866 38 (1) (3) Rare Disease 9,126 16 4 4 2,374 15 - (1) Other Medicines 999 2 (9) (8) 235 2 (7) (8) Total Revenue 58,739 100 9 8 15,503 100 4 2 Table 6: Total Revenue by region FY 2025 % Change Q4 2025 % Change $m % Total Actual CER $m % Total Actual CER US 25,450 43 10 10 6,932 45 6 6 Emerging Markets ex. China 8,649 15 19 22 2,271 15 28 24 China 6,654 11 4 4 1,375 9 1 1 Emerging Markets 15,303 26 12 14 3,646 24 16 14 Europe 12,739 22 5 1 3,579 23 (9) (15) Established RoW 5,247 9 5 6 1,345 9 5 7 Total Revenue 58,739 100 9 8 15,503 100 4 2 Table 7: Product Revenue by region FY 2025 % Change Q4 2025 % Change $m % Total Actual CER $m % Total Actual CER US 25,449 43 10 10 6,932 45 8 8 Emerging Markets ex. China 8,649 15 19 22 2,271 15 28 24 China 6,654 11 4 4 1,375 9 1 1 Emerging Markets 15,303 26 12 14 3,646 24 16 14 Europe 12,739 22 11 7 3,579 23 10 3 Established RoW 5,149 9 5 5 1,340 9 5 7 Total Product Revenue 58,640 100 10 10 15,497 100 10 8 ===== SIDA 9 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 9 Total Revenue by Medicine Oncology Tagrisso FY 2025 $m Total Revenue % Change Actual CER  Strong demand growth across all indications and key regions, leading combination in 1L NSCLC (FLAURA2) US 3,064 11 11  Underlying demand growth more than offset Medicare Part D redesign Emerging Markets 1,971 12 14  Continued demand growth, with quarterly revenue profile reflecting usual seasonal ordering dynamics in China Europe 1,423 9 6  Demand growth partially offset by pricing pressure in certain major markets Established RoW 796 5 5 Total 7,254 10 10 Imfinzi FY 2025 $m Total Revenue % Change Actual CER  Strong growth from new launch indications in bladder cancer (NIAGARA) and lung cancer (ADRIATIC, AEGEAN) US 3,509 35 35  Demand growth across all indications, particularly new launches Emerging Markets 640 34 38  Demand growth in GI (HIMALAYA, TOPAZ-1) and launches in lung cancer and bladder Europe 1,239 31 26  Growth from bladder and GI indications and momentum from lung cancer launches Established RoW 675 (2) (2)  Mandatory price reductions in Japan in Feb 2024 (25%), and Aug 2024 (11%), increased competition in BTC (TOPAZ-1) Total 6,063 29 28 Calquence FY 2025 $m Total Revenue % Change Actual CER  Growth from sustained BTKi leadership in front-line CLL US 2,339 7 7  Growth in new patient starts in CLL, 1L MCL (ECHO) launch and improved affordability offsetting Medicare Part D redesign and also discounts to secure preferential formulary placement Emerging Markets 233 52 54  1L and r/r CLL growth Europe 784 20 15  Early launch momentum in fixed duration 1L CLL (AMPLIFY) Established RoW 162 25 27 Total 3,518 12 12 Lynparza FY 2025 $m Total Revenue % Change Actual CER  Sustained global PARP inhibitor market leadership across four tumour types (ovarian, breast, prostate, pancreatic) US 1,434 8 8  Share gains across ovarian, breast and prostate indications Emerging Markets 669 2 1  Affected by generic competition in China and stock compensation in Q4 2025 ahead of anticipated VBP implementation in Q1 2026 Europe 914 (36) (38)  Year-on-year comparison reflects sales-related milestone recorded in Q4 2024; launches in breast and prostate cancers (OlympiA and PROpel) Established RoW 262 3 4  Gains in 1L ovarian, increasing share of pMMR endometrial cancer (DUO-E) Total 3,279 (11) (12) ===== SIDA 10 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 10 Enhertu Combined sales of Enhertu, recorded by Daiichi Sankyo and AstraZeneca, amounted to $4,982m in FY 2025 (FY 2024: $3,754m). US in- market sales, recorded by Daiichi Sankyo, amounted to $2,446m in FY 2025 (FY 2024: $1,864m). Up to and including Q3 2025, AstraZeneca’s mid-single-digit percentage royalty on Daiichi Sankyo's sales in Japan was recorded as Alliance Revenue in Europe. From Q4 2025 this royalty is recorded in Established RoW. FY 2025 $m Total Revenue % Change Actual CER  Standard-of-care in HER2-positive (DESTINY-Breast03) and HER2-low (DESTINY- Breast04) metastatic breast cancer, early uptake in other cancers  US 1,176 32 32  Accelerated uptake in chemotherapy naïve HER2-low and -ultralow breast cancer Emerging Markets 829 74 79  Rapid adoption post-NRDL enlistment of HER2-positive and HER2-low breast cancer from 1 January 2025 Europe 665 23 18  Demand growth in chemotherapy naïve HER2-low breast cancer; Q4 2025 includes favourable gross-to-net adjustment Established RoW 105 52 55 Total 2,775 40 40 Other Oncology medicines FY 2025 $m Total Revenue % Change Actual CER Zoladex 1,151 5 6  Growth across Emerging Markets Truqap 728 69 68  Rapidly reached peak share in second-line biomarker-altered metastatic breast cancer; Q4 2025 also benefited from year-end ordering dynamics in the US Imjudo 346 23 23  Continued growth driven by lung (POSEIDON) and HCC (HIMALAYA) Datroway 78 n/m n/m  Continued uptake in breast cancer and EGFRm later-line lung cancer  Combined global sales by AstraZeneca and Daichi Sankyo of $218m (FY 2024: $nil) Other Oncology 427 (8) (8)  Faslodex generic erosion across markets Other Oncology includes $28m of Total Revenue from Orpathys, partnered with HUTCHMED. BioPharmaceuticals - CVRM Farxiga FY 2025 $m Total Revenue % Change Actual CER  Growth driven by HF and CKD indications, SGLT2 class growth supported by cardiorenal guidelines US 1,730 (1) (1)  Prior year benefitted from authorised generic launch Emerging Markets 3,324 17 18  Continued strong growth despite generic competition in some markets. Stock compensation in Q4 2025 ahead of anticipated VBP implementation in Q1 2026 Europe 2,941 12 8  Demand growth offset by generic entry in the UK in Q3 2025 Established RoW 497 4 4  Generic T2D entry in Japan in Q4 2025 Total 8,492 10 9 Other CVRM medicines FY 2025 $m Total Revenue % Change Actual CER Crestor 1,218 5 6  Growth driven by Emerging Markets Brilinta 823 (38) (38)  Decline driven by generic entry in the US and Europe in Q2 2025 Seloken 608 - 2  Vast majority of revenue growth driven by Ex-China Emerging Markets Lokelma 698 29 28  Strong growth in all major regions with launches in new markets roxadustat 276 (18) (18)  Generic competition and China VBP stock compensation in Q4 2025 Wainua 212 >2x >2x  Majority of revenue from US; first launches in ex-US markets in Q2 2025 Other CVRM 534 (28) (28)  Generic erosion ===== SIDA 11 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 11 BioPharmaceuticals - R&I Symbicort FY 2025 $m Total Revenue % Change Actual CER  Sustained market leader in a stable ICS/LABA class, treating COPD and asthma US 1,193 1 1  Demand for authorised generic partially offsetting brand price pressures Emerging Markets 801 (1) 1  China affected by ICS/LABA class erosion in COPD in favour of FDC triple therapy Europe 560 - (3)  Continued generic erosion Established RoW 331 1 3 Total 2,885 - - Fasenra FY 2025 $m Total Revenue % Change Actual CER  Expanded severe eosinophilic asthma market share leadership in IL-5 class, further fuelled by first wave market launches for EGPA indication US 1,195 14 14  Sustained double-digit volume growth with expanded class leadership. Q4 2025 includes unfavourable gross-to-net adjustment Emerging Markets 117 27 29  Asthma launch momentum across key markets  Europe 482 19 15  Sustained leadership in severe eosinophilic asthma Established RoW 187 29 30  Strong growth supported by EGPA launch in Japan Total 1,981 17 16 Breztri FY 2025 $m Total Revenue % Change Actual CER  Fastest growing medicine within the expanding FDC triple class (ICS/LABA/LAMA), treating COPD US 614 19 19  Consistent share growth within expanding FDC triple class. Q4 2025 includes unfavourable gross-to-net adjustment Emerging Markets 298 22 22  Market share leadership within the growing FDC triple class in China Europe 191 33 29  Sustained growth from market share gain and new launches Established RoW 96 30 30  Increasing market share in Japan Total 1,199 23 22 Tezspire Combined sales of Tezspire, recorded by Amgen and AstraZeneca, amounted to $1,936m in FY 2025 (FY 2024: $1,291m). FY 2025 $m Total Revenue % Change Actual CER  Sustained demand growth in severe asthma with launch momentum across multiple markets US 673 54 54  Continued strong demand growth with increasing new patient share volumes in biologics segment Emerging Markets 40 >3x >3x  Strong continued launch uptake Europe 297 90 83  Maintained new-to-brand leadership across multiple markets and new launches Established RoW 121 51 51  Strong growth driven by Japan Total 1,131 65 64 Other R&I medicines FY 2025 $m Total Revenue % Change Actual CER Pulmicort 518 (24) (24)  Generic competition in Emerging Markets (~80% of revenue) Saphnelo 686 45 44  Strong US demand growth, ongoing launches in Europe and Established RoW Airsupra 166 >2x >2x  Strong US launch momentum and volume uptake Other R&I 300 (29) (29) ===== SIDA 12 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 12 BioPharmaceuticals - V&I Beyfortus Total Revenue reflects the sum of Product Sales from AstraZeneca’s sales of manufactured product to Sanofi and Alliance Revenue from AstraZeneca’s share of gross profits and royalties on sales in major markets outside the US. FY 2025 $m Total Revenue % Change Actual CER Beyfortus 703 (3) (3)  Year-on-year comparison affected by Collaboration Revenue of $167m in 2024 Synagis 292 (35) (34)  Competition from Beyfortus FluMist 272 6 3 Other V&I 1 (96) (96) Rare Disease Ultomiris Ultomiris Total Revenue includes sales of Voydeya, which is approved as an add-on treatment to Ultomiris and Soliris for the ~20-30% of PNH patients who experience clinically significant EVH. FY 2025 $m Total Revenue % Change Actual CER  Growth due to patient demand, both naïve to branded medicines and conversion from Soliris across all indications (gMG, NMOSD, aHUS and PNH) US 2,667 18 18  Demand growth across indications, including within the competitive gMG and PNH landscapes Emerging Markets 261 84 90  Expansion into new markets and growth in patient demand Europe 1,053 19 15  Strong demand growth following recent launches; competition in gMG and PNH Established RoW 737 16 15  Continued conversion and strong demand following new launches Total 4,718 20 19 Soliris FY 2025 $m Total Revenue % Change Actual CER  Decline driven by conversion of patients to Ultomiris across all indications, competition, and biosimilar pressure in Europe and US US 1,092 (28) (28)  Conversion to Ultomiris, competition in gMG and PNH, and biosimilar pressure in gMG, PNH and aHUS Emerging Markets 405 (9) (1) Europe 200 (52) (53)  Conversion to Ultomiris, competition in gMG and PNH, and biosimilar pressure in PNH and aHUS Established RoW 140 (32) (31)  Conversion to Ultomiris Total 1,837 (29) (28) Strensiq FY 2025 $m Total Revenue % Change Actual CER  Growth driven by continued HPP patient demand and geographic expansion US 1,332 14 14  Demand growth, offset by Medicare Part D redesign Emerging Markets 104 94 84  Q4 2025 benefitted from favourable timing of tender orders Europe 123 25 21 Established RoW 119 23 23 Total 1,678 19 18 Other Rare Disease medicines FY 2025 $m Total Revenue % Change Actual CER Koselugo 662 5 3  Growth driven by continued patient demand and geographic expansion. Growth rates in Q3 and Q4 reflect order timing in certain tender markets Other Rare Disease 231 11 10  Other Rare Disease medicines include Kanuma and Beyonttra (JP only) Other Medicines FY 2025 $m Total Revenue % Change Actual CER Nexium 831 (6) (5)  Growth in Emerging Markets, generic erosion elsewhere Others 168 (20) (20)  Generic erosion ===== SIDA 13 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 13 This section covers R&D events and milestones that occurred from 6 November 2025 to 9 February 2026. A comprehensive view of AstraZeneca's pipeline of medicines in human trials can be found in the latest Clinical Trials Appendix, available on AstraZeneca’s investor relations webpage. The Clinical Trials Appendix includes tables with details of the ongoing clinical trials for AstraZeneca medicines and new molecular entities in the pipeline. Oncology AstraZeneca presented new data across its diverse portfolio of cancer medicines at two major medical congresses since the prior results announcement: the American Society of Hematology Annual Meeting and Exposition 2025 (ASH) and the San Antonio Breast Cancer Symposium 2025 (SABCS). Across the two meetings, 120 abstracts were presented featuring 19 approved and potential new medicines including 29 oral presentations. Datroway Phase III trial update TROPION-Lung12 December 2025 New disclosure  Recruitment into the TROPION-Lung12 Phase III trial of adjuvant Datroway in combination with rilvegostomig or rilvegostomig monotherapy versus standard-of- care, following complete tumour resection, in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive or have high-risk pathological features has been discontinued due to operational feasibility. There were no new safety signals. Priority review US TROPION-Breast02 February 2025  Unresectable or metastatic TNBC for patients that are not candidates for PD-1/PD-L1 inhibitor therapy. Enhertu Approval EU DESTINY-Gastric04 November 2025 New disclosure  Locally advanced or metastatic HER2-positive (IHC3+ or IHC2+/ISH+) gastric or gastroesophageal junction adenocarcinoma who have received a prior trastuzumab- based regimen. Approval US DESTINY-Breast09 December 2025  1st-line treatment for unresectable or metastatic HER2-positive breast cancer. Approval CN DESTINY-Breast06 December 2025 New disclosure  Unresectable or metastatic HR-positive, HER2 low (IHC 1+ or IHC 2+/ISH-) or HER2 ultralow (IHC 0 with membrane staining) breast cancer that has progressed on one or more endocrine therapies in the metastatic setting. Approval CN DESTINY-Gastric04 January 2026 New disclosure  Locally advanced or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinoma who have received one prior trastuzumab based regimen. Imfinzi Approval CN PACIFIC-5 November 2025 New disclosure  Unresectable Stage III NSCLC with no known sensitising EGFRm or ALK rearrangements whose disease has not progressed following platinum-based chemotherapy and radiation therapy. Approval US MATTERHORN November 2025  In combination with FLOT chemotherapy as neoadjuvant and adjuvant treatment, followed by single agent Imfinzi, for the treatment of resectable gastric or gastroesophageal junction adenocarcinoma. Approval CN DUO-E January 2026 New disclosure  In combination with carboplatin and paclitaxel for the 1st-line treatment of adult patients with primary advanced or recurrent endometrial cancer that is mismatch repair deficient, followed by Imfinzi as a single agent for maintenance treatment. CHMP opinion EU MATTERHORN January 2026  Recommended in combination with standard-of-care FLOT chemotherapy for the treatment of resectable, early-stage and locally advanced (Stages II, III, IVA) gastric and gastroesophageal junction cancers. Lynparza Regulatory update Global DUO-O Q4 2025 New disclosure  Following further data follow up and health authority interactions, the decision has been taken to not progress with regulatory filings in US, Europe, China or Japan. R&D progress ===== SIDA 14 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 14 ceralasertib Phase III trial update LATIFY December 2025  The LATIFY Phase III trial of ceralasertib in combination with Imfinzi did not meet the primary endpoint of OS versus standard-of-care docetaxel in patients with locally advanced or metastatic NSCLC whose disease progressed on or after prior immunotherapy and platinum-based chemotherapy. BioPharmaceuticals – CVRM baxdrostat Data presentation AHA Bax24 November 2025  Positive results from the Bax24 Phase III trial showed baxdrostat showed clinically meaningful and consistent blood pressure reductions versus placebo in patients with treatment-resistant hypertension. At 12 weeks, the placebo-adjusted reduction in ambulatory 24-hour average SBP was 14.0 mmHg (95% CI -17.2, -10.8; p<0.0001). Efficacy was observed throughout the 24-hour period, including early morning, when patients with hypertension are at a higher risk of cardiovascular events. Priority Review US BaxHTN December 2025  For uncontrolled or treatment-resistant hypertension as an add-on to other antihypertensive medicines when these do not provide adequate lowering of blood pressure. Phase III readout BaxAsia December 2025 New disclosure  High-level results from the supportive BaxAsia Phase III trial showed baxdrostat 2mg met the primary endpoint, demonstrating a statistically significant and clinically meaningful reduction in mean seated systolic blood pressure at 12 weeks compared with placebo in patients with uncontrolled or treatment-resistant hypertension. The preliminary safety profile was consistent to that seen in previous baxdrostat trials. Wainua Approval CN NEURO-TTRansform December 2025  For the treatment of adult patients with polyneuropathy associated with hereditary transthyretin-mediated amyloidosis (ATTRv-PN). elecoglipron (AZD5004) Phase IIb readout VISTA February 2026 New disclosure  Positive high-level results showed that treatment with elecoglipron in participants with obesity or overweight and at least one comorbidity met the primary endpoints (change in body weight from baseline at 26 weeks and proportion of participants with weight loss ≥5% from baseline weight at 26 weeks), supporting initiation of a Phase III programme. Phase IIb readout SOLSTICE February 2026 New disclosure  Positive high-level results showed that treatment with elecoglipron in participants with T2D met the primary endpoint (change in HbA1c from baseline at 26 weeks), supporting initiation of a Phase III programme. ===== SIDA 15 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 15 BioPharmaceuticals – R&I Fasenra Approval CN MANDARA December 2025 New disclosure  For adult patients with eosinophilic granulomatosis with polyangiitis (EGPA). Saphnelo Approval EU TULIP-SC December 2025  For subcutaneous self-administration as a pre-filled pen for adult patients with systemic lupus erythematosus on top of standard therapy. Data publication TULIP-SC January 2026  Positive full results showed the subcutaneous administration of Saphnelo demonstrated a statistically significant and clinically meaningful reduction in disease activity compared to placebo in patients with systemic lupus erythematosus. 56.2% of patients who received Saphnelo achieved a reduction in disease activity at Week 52 versus 37.1% receiving placebo, as measured by the British Isles Lupus Assessment Group-based Composite Lupus Assessment (95% CI 9.0, 29.2%; p=0.0002). Regulatory update US TULIP-SC February 2026  The FDA issued a complete response letter regarding the Biologics License Application for Saphnelo for subcutaneous administration in adult patients with systemic lupus erythematosus. AstraZeneca subsequently provided the information requested in the CRL and is committed to working with the FDA to progress the application as quickly as possible. A decision from the FDA on the updated application for Saphnelo SC is expected in H1 2026 Rare Disease Koselugo Approval US KOMET November 2025  For the treatment of adult patients with symptomatic, inoperable plexiform neurofibromas in neurofibromatosis type 1. Approval EU SPRINKLE January 2026 New disclosure  Granule formulation for paediatric patients one year of age and older with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas. Soliris Approval CN NCT03759366 January 2026 New disclosure  For expanded use to include the treatment of refractory gMG in paediatric patients aged six years and older who are anti-acetylcholine receptor antibody-positive. ===== SIDA 16 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 16 Sustainability highlights – For the tenth year, AstraZeneca was recognised by CDP for climate action and water stewardship, receiving an A for Climate and A– for Water Security in 2025, reflecting the Company’s progress in decarbonising and reducing its environmental footprint. – AstraZeneca was also named by TIME Magazine as one of the World’s Best Companies in Sustainable Growth 2026, ranking among the top pharmaceutical companies for combined financial and environmental performance for the second year in a row. Climate and nature – At the end of 2025, the Company’s cumulative reduction in Scope 1 and 2 greenhouse gas emissions was 88% from the 2015 baseline. – In November 2025, Alexion, AstraZeneca Rare Disease, announced an agreement with Carbon AMS to supply biomethane to meet 100% of the heating needs at its Ireland manufacturing sites. The agreement will add renewable capacity to Ireland’s national gas grid and produce 32 GWh of biomethane annually for Alexion. This milestone is an important step to transitioning to 100% renewables and follows a series of innovative clean heat partnerships announced in the US, UK and China. – In January 2026, AstraZeneca hosted a pan-European media event at the Company’s Dunkirk manufacturing site in France, focused on the Company’s first approval of a pressurised metered dose inhaler using a next-generation propellant with near-zero Global Warming Potential. – AstraZeneca celebrated the inauguration of a new photovoltaic installation at its facility in Puerto Rico that will cut the site's greenhouse gas emissions by 173 tons of carbon dioxide equivalents annually, equivalent to an 8% reduction versus current emissions. – The Sustainable Markets Initiative (SMI) Health Systems Task Force, chaired by AstraZeneca CEO Pascal Soriot, supported the development and launch of PSA 2090, the world’s first global standard to measure and assess the environmental impact of pharmaceutical products through their lifecycle, in collaboration with BSI, NHS England and key partners. In addition, through the SMI, Chief Procurement Officers published a joint open letter to suppliers, encouraging common action to accelerate climate and nature action across the value chain and the use of joint targets for suppliers. – AstraZeneca joined government-hosted sessions at the 2025 United Nations Climate Change Conference (COP30) in November, held in Belém, Brazil. AstraZeneca senior leaders underlined how sustainable healthcare and early action on chronic disease can improve the health of people and the planet and shared new evidence to support healthcare decarbonisation, focused on type 2 diabetes and CKD. AstraZeneca was the only pharmaceutical company represented at official COP30 events. Health equity – As at end 2025, the expanded Healthy Heart Africa (HHA) programme, which includes CKD screening, diagnosis and management, had successfully launched in Rwanda, Ivory Coast, Ethiopia, Egypt, and Senegal. CKD guidelines, developed in partnership with Ministries of Health, were launched in six countries. New findings from the HHA extension study of INSIDE CKD, presented at economics conference ISPOR in November, highlighted the need for early action on chronic disease. – CEO, Alexion and AstraZeneca’s Chief Strategy Officer Marc Dunoyer renewed AstraZeneca’s commitment to China’s rare disease ecosystem at the second China Rare Disease Policy and Access Forum in Beijing in October, hosted by the China Alliance for Rare Diseases. – AstraZeneca played a central role in driving public-private partnerships that aim to support the implementation of the World Health Assembly Rare Disease Resolution into meaningful advances for patients across Southeast Asia. In November, the SEA Rare Disease Policy Forum, hosted by the Malaysian Ministry of Health and organised by patient groups the Asia Pacific Alliance of Rare Disease Organisations, supported by Rare Diseases International, advocated for advancements in health equity in the region. – In November 2025, at the 2025 One Young World Summit in Munich, AstraZeneca’s Chief Financial Officer Aradhana Sarin gave a keynote address on why investing in and supporting young people to prevent diseases is key to building resilient, equitable health systems. The Company’s delegation included 15 AstraZeneca Young Health Programme Impact Fellows as well as leaders and 90 employees. – AstraZeneca marked the UN’s International Day of the Girl on 11 October 2025, including via a Girls Belong Here initiative where young women stepped into senior roles for the day. More than 120 girls from across 12 countries participated. Health systems resilience – In December, the Partnership for Health System Sustainability and Resilience (PHSSR), a partnership co- founded by AstraZeneca, launched policy recommendations on how to improve non-communicable diseases (NCDs) prevention and treatment in Greece. This preceded the launch of a White Paper on Acting Early on Non- Communicable Diseases: A Framework for Health System Transformation in January 2026 which provides recommendations on how to tackle the NCD crisis, drawing from new research in Canada, France, Germany, Greece, Italy, Japan, Poland, and Spain. – AstraZeneca also hosted a discussion at the European Parliament, ‘Investing in Health for a Competitive, Secure, and Resilient Europe’, to discuss how PHSSR’s recommendations from their report on sustainable healthcare financing can strengthen investment in health across Europe. How we do business – AstraZeneca marked Global Ethics Day on 15 October with a week of events to highlight the importance of ethical decision making, behaviours and practices, and launched the Company’s annual mandatory Code of Ethics training for all employees and the 2025 Ethics Survey. Sustainability ===== SIDA 17 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 17 Reporting currency All narrative on growth and results in this section is based on actual exchange rates, and financial figures are in US$ millions ($m), unless stated otherwise. Reporting period The performance shown in this announcement covers the twelve-month period to 31 December 2025 (‘the period’ or ‘FY 2025’) compared to the twelve- month period to 31 December 2024 (‘FY 2024’), or the three-month period to 31 December 2025 (‘the quarter’ or ‘Q4 2025’) compared to the three-month period to 31 December 2024 (‘Q4 2024’), unless stated otherwise. Core financial measures Core financial measures, EBITDA, Net debt, Gross Margin, Operating Margin and CER are non-GAAP financial measures because they cannot be derived directly from the Group's Condensed consolidated financial statements. Management believes that these non- GAAP financial measures, when provided in combination with Reported results, provide investors and analysts with helpful supplementary information to better understand the financial performance and position of the Group on a comparable basis from period to period. These non-GAAP financial measures are not a substitute for, or superior to, financial measures prepared in accordance with GAAP. Core financial measures (cont.) Core financial measures are adjusted to exclude certain significant items: – Charges and provisions related to our global restructuring programmes, which includes charges that relate to the impact of restructuring programmes on our capitalised manufacturing assets and IT assets – Amortisation and impairment of intangible assets, including impairment reversals but excluding any charges relating to IT assets – Other specified items, principally comprising acquisition-related costs and credits, which include the imputed finance charges and fair value movements relating to contingent consideration on business combinations, imputed finance charges and remeasurement adjustments on certain Other payables arising from intangible asset acquisitions, remeasurement adjustments relating to certain Other payables, debt items assumed from the Alexion acquisition and legal settlements – The tax effects of the adjustments above are excluded from the Core Tax charge Details on the nature of Core financial measures are provided on page 70 of the Annual Report and Form 20-F Information 2024. Reference should be made to the Reconciliation of Reported to Core financial measures table included in the Financial Performance section in this announcement. Definitions Gross Margin is defined as Gross Profit as a percentage of Total Revenue. EBITDA is defined as Reported Profit before tax after adding back Net finance expense, results from Joint ventures and associates and charges for Depreciation, amortisation and impairment. Reference should be made to the Reconciliation of Reported Profit before tax to EBITDA included in the Financial Performance section in this announcement. Operating margin is defined as Operating profit as a percentage of Total Revenue. Net debt is defined as Interest-bearing loans and borrowings and Lease liabilities, net of Cash and cash equivalents, Other investments, and Net derivative financial instruments. Reference should be made to Note 3 'Net debt', included in the Notes to the Condensed consolidated financial statements in this announcement. The Company strongly encourages investors and analysts not to rely on any single financial measure, but to review AstraZeneca's financial statements, including the Notes thereto, and other available Company reports, carefully and in their entirety. Due to rounding, the sum of a number of dollar values and percentages in this announcement may not agree to totals. Operating and financial review ===== SIDA 18 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 18 Table 8: Reported Profit and Loss FY 2025 FY 2024 % Change Q4 2025 Q4 2024 % Change $m $m Actual CER $m $m Actual CER - Product Sales 55,573 50,938 9 9 14,538 13,362 9 7 - Alliance Revenue 3,067 2,212 39 38 959 714 34 33 Product Revenue 58,640 53,150 10 10 15,497 14,076 10 8 Collaboration Revenue 99 923 (89) (89) 6 815 (99) (99) Total Revenue 58,739 54,073 9 8 15,503 14,891 4 2 Cost of sales (10,633) (10,207) 4 5 (3,118) (2,725) 14 14 Gross profit 48,106 43,866 10 9 12,385 12,166 2 - Distribution expense (579) (555) 4 4 (153) (143) 7 4 R&D expense (14,232) (13,583) 5 4 (3,862) (4,677) (17) (19) SG&A expense (19,933) (19,977) - (1) (5,492) (5,410) 2 - Other operating income & expense 381 252 52 53 100 100 - 2 Operating profit 13,743 10,003 37 36 2,978 2,036 46 40 Net finance expense (1,334) (1,284) 4 5 (349) (365) (4) (2) Joint ventures and associates (7) (28) (74) (77) - (5) n/m n/m Profit before tax 12,402 8,691 43 40 2,629 1,666 58 49 Taxation (2,169) (1,650) 31 29 (300) (166) 82 66 Tax rate 18% 19% 11% 10% Profit after tax 10,233 7,041 45 43 2,329 1,500 55 47 Earnings per share $6.60 $4.54 45 43 $1.50 $0.97 55 47 Table 9: Reconciliation of Reported Profit before tax to EBITDA FY 2025 FY 2024 % Change Q4 2025 Q4 2024 % Change $m $m Actual CER $m $m Actual CER Reported Profit before tax 12,402 8,691 43 40 2,629 1,666 58 49 Net finance expense 1,334 1,284 4 5 349 365 (4) (2) Joint ventures and associates 7 28 (74) (77) - 5 n/m n/m Depreciation, amortisation and impairment 5,733 6,688 (14) (15) 1,511 2,337 (35) (37) EBITDA 19,476 16,691 17 16 4,489 4,373 3 - Table 10: Reconciliation of Reported to Core financial measures: FY 2025 For the twelve months ended 31 December Reported Restructuring Intangible Asset Amortisation & Impairments Other Core % Change $m $m $m $m $m Actual CER Gross profit 48,106 (138) 32 30 48,030 8 7 - Gross Margin 82% 82% - -1pp Distribution expense (579) - - - (579) 4 4 R&D expense (14,232) 171 236 3 (13,822) 13 12 - R&D % of Total Revenue 24% 24% -1pp -1pp SG&A expense (19,933) 209 4,059 131 (15,534) 3 3 - SG&A % of Total Revenue 34% 26% +1pp +1pp Total operating expense (34,744) 380 4,295 134 (29,935) 8 7 Other operating income & expense 381 (5) - 7 383 54 55 Operating profit 13,743 237 4,327 171 18,478 9 9 - Operating Margin 23% 31% - - Net finance expense (1,334) - - 242 (1,092) (7) (6) Taxation (2,169) (68) (825) (108) (3,170) 6 5 EPS $6.60 $0.11 $2.26 $0.19 $9.16 12 11 Financial performance ===== SIDA 19 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 19 Table 11: Reconciliation of Reported to Core financial measures: Q4 2025 For the quarter ended 31 December Reported Restructuring Intangible Asset Amortisation & Impairments Other Core % Change $m $m $m $m $m Actual CER Gross profit 12,385 (77) 8 18 12,334 2 - - Gross Margin 80% 80% -2pp -2pp Distribution expense (153) - - - (153) 7 4 R&D expense (3,862) 37 95 (1) (3,731) 4 3 - R&D % of Total Revenue 25% 24% - - SG&A expense (5,492) 96 1,021 (78) (4,453) 4 2 - SG&A % of Total Revenue 35% 29% - - Total operating expense (9,507) 133 1,116 (79) (8,337) 4 2 Other operating income & expense 100 1 - - 101 2 2 Operating profit 2,978 57 1,124 (61) 4,098 (2) (5) - Operating Margin 19% 26% -2pp -2pp Net finance expense (349) - - 80 (269) (13) (10) Taxation (300) (19) (214) (10) (543) (15) (19) EPS $1.50 $0.03 $0.58 $0.01 $2.12 1 (2) Profit and Loss drivers Gross profit The movement in Gross Margin in FY 2025 was a result of: – Positive effects from geographic mix – Negative effects from product mix. The rising contribution of Product Sales with profit sharing arrangements (Lynparza, Enhertu, Datroway, Tezspire, Koselugo) has a negative impact on Gross Margin because AstraZeneca records Product Sales in certain markets and pays away a share of the gross profits to its collaboration partners. The profit share paid to partners is recorded in AstraZeneca’s Cost of sales line – Pricing adjustments, e.g. to sales reimbursed by the Medicare Part D programme in the US, diluted the Gross Margin – Royalty buyout expenses of $235m, incurred in the fourth quarter Variations in Gross Margin performance between periods can continue to be expected due to product seasonality, foreign exchange fluctuations, and other effects. R&D expense The increase in R&D expense (Reported and Core) in the period was driven by: – Positive data readouts for high-value pipeline opportunities that have ungated late-stage trials – Investment in platforms, new technology and capabilities to enhance R&D capabilities – Addition of R&D projects following completion of previously announced business development activity The change in Reported R&D expense also reflects a $753m impairment charge recorded against the vemircopan (ALXN2050) intangible asset in FY 2024. SG&A expense – The increase in SG&A expense (Reported and Core) in the period was driven primarily by market development activities for launches and to support continued growth in existing brands – The change in Reported SG&A expense also reflects a $504m impairment charge recorded against the Andexxa intangible asset in FY 2024 Other operating income and expense – Other operating income in FY 2025 consisted primarily of royalties and an upfront fee income on a divestment Net finance expense Core Net finance expense decreased 7% (6% at CER) in FY 2025, principally due to changes in interest on tax, with movements in borrowing expenses broadly offset by lower interest income on cash balances. Taxation The effective Reported and Core tax rates for the twelve months to 31 December 2025 were 18% (FY 2024: 19%). Dividends A second interim dividend of $2.17 per share (159.5 pence, 19.49 SEK) has been declared, resulting in a full-year dividend per share of $3.20. Dividend payments are normally paid as follows: – First interim dividend - announced with half-year and second-quarter results and paid in September – Second interim dividend - announced with full-year and fourth-quarter results and paid in March – Dates for the FY 2025 second interim dividend: ex-dividend 19 February 2026 (for shares traded on the London Stock Exchange or Nasdaq Stockholm), ex-dividend 20 February 2026 (for shares traded on the New York Stock Exchange), record date 20 February 2026, payable on 23 March 2026 ===== SIDA 20 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 20 Cash Flow Table 12: Cash Flow summary: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m Change $m Reported Operating profit 13,743 10,003 3,740 Depreciation, amortisation and impairment 5,733 6,688 (955) Movement in working capital and short-term provisions (1,137) (893) (244) Gains on disposal of intangible assets (168) (64) (104) Fair value movements on contingent consideration arising from business combinations (97) 311 (408) Non-cash and other movements 662 (121) 783 Interest paid (1,316) (1,313) (3) Taxation paid (2,845) (2,750) (95) Net cash inflow from operating activities 14,575 11,861 2,714 Net cash inflow before financing activities 7,767 3,881 3,886 Net cash outflow from financing activities (7,544) (3,996) (3,548) Net cash flow The change in Net cash inflow from operating activities of $2,714m is primarily driven by the increased Operating profit in FY2025. The change in Net cash inflow before financing activities of $3,886m is primarily driven by, in addition to the change in Net cash inflow from operating activities, a reduction of $2,705m in cash outflow relating to the Acquisitions of subsidiaries, net of cash acquired, offset by an increase of $1,052m relating to capital expenditure on tangible assets and software-related intangible assets. In FY2024 the cash outflow relating to the Acquisitions of subsidiaries, net of cash acquired, included $1,997m related to the acquisition of Fusion Pharmaceuticals Inc. and $774m related to the acquisition of Gracell Biotechnologies Inc. The change in Net cash outflow from financing activities of $3,548m is primarily driven by the issue of new long-term loans of $6,492m in FY2024, with no issuance in FY2025, and offset by the repayment of loans of $2,029m in the current period compared to $4,652m of loans repaid in comparative period. Capital expenditure Capital expenditure on tangible assets and software-related intangible assets amounted to $3,270m in FY 2025 (FY 2024: $2,218m). The increase of capital expenditure in FY2025 was driven by investment in several major manufacturing projects and continued investment in technology upgrades. Net debt Net debt decreased by $1,196m in the twelve months to 31 December 2025 to $23,374m. Details of the committed undrawn bank facilities are disclosed within the Going concern section of Note 1. Details of the Company's solicited credit ratings and further details on Net debt are disclosed in Note 3. Net debt Table 13: Net debt summary At 31 Dec 2025 $m At 31 Dec 2024 $m Cash and cash equivalents 5,711 5,488 Other investments 30 166 Cash and investments 5,741 5,654 Overdrafts and short-term borrowings (644) (330) Lease liabilities (1,803) (1,452) Current instalments of loans (2,460) (2,007) Non-current instalments of loans (24,715) (26,506) Interest-bearing loans and borrowings (Gross debt) (29,622) (30,295) Net derivatives 507 71 Net debt (23,374) (24,570) ===== SIDA 21 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 21 Summarised financial information for guarantee of securities of subsidiaries AstraZeneca Finance LLC ("AstraZeneca Finance") is the issuer of 1.2% Notes due 2026, 4.8% Notes due 2027, 4.875% Notes due 2028, 1.75% Notes due 2028, 4.85% Notes due 2029, 4.9% Notes due 2030, 4.9% Notes due 2031, 2.25% Notes due 2031, 4.875% Notes due 2033 and 5% Notes due 2034 (the "AstraZeneca Finance USD Notes"). Each series of AstraZeneca Finance USD Notes has been fully and unconditionally guaranteed by AstraZeneca PLC. AstraZeneca Finance is 100% owned by AstraZeneca PLC and each of the guarantees issued by AstraZeneca PLC is full and unconditional and joint and several. The AstraZeneca Finance USD Notes are senior unsecured obligations of AstraZeneca Finance and rank equally with all of AstraZeneca Finance's existing and future senior unsecured and unsubordinated indebtedness. The guarantee by AstraZeneca PLC of the AstraZeneca Finance USD Notes is the senior unsecured obligation of AstraZeneca PLC and ranks equally with all of AstraZeneca PLC's existing and future senior unsecured and unsubordinated indebtedness. Each guarantee by AstraZeneca PLC is effectively subordinated to any secured indebtedness of AstraZeneca PLC to the extent of the value of the assets securing such indebtedness. The AstraZeneca Finance USD Notes are structurally subordinated to indebtedness and other liabilities of the subsidiaries of AstraZeneca PLC, none of which guarantee the AstraZeneca Finance USD Notes. AstraZeneca PLC manages substantially all of its operations through divisions, branches and/or investments in subsidiaries and affiliates. Accordingly, the ability of AstraZeneca PLC to service its debt and guarantee obligations is also dependent upon the earnings of its subsidiaries, affiliates, branches and divisions, whether by dividends, distributions, loans or otherwise. Please refer to the Consolidated financial statements of AstraZeneca PLC in our Annual Report on Form 20-F as filed with the SEC and information contained herein for further financial information regarding AstraZeneca PLC and its consolidated subsidiaries. For further details, terms and conditions of the AstraZeneca Finance USD Notes please refer to AstraZeneca PLC's reports on Form 6-K furnished to the SEC on 22 February 2024, 3 March 2023 and 28 May 2021. Pursuant to Rule 13-01 and Rule 3-10 of Regulation S-X under the Securities Act of 1933, as amended (the "Securities Act"), we present below the summary financial information for AstraZeneca PLC, as Guarantor, excluding its consolidated subsidiaries, and AstraZeneca Finance, as the issuer, excluding its consolidated subsidiaries. The following summary financial information of AstraZeneca PLC and AstraZeneca Finance is presented on a combined basis and transactions between the combining entities have been eliminated. Financial information for non- guarantor entities has been excluded. Intercompany balances and transactions between the obligor group and the non- obligor subsidiaries are presented on separate lines. Obligor group summarised statements Table 14: Obligor group summarised Statement of comprehensive income: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m Total Revenue - - Gross profit - - Operating loss (27) (34) Loss for the period (1,756) (1,182) Transactions with subsidiaries that are not issuers or guarantors 7,588 1,661 Table 15: Obligor group summarised Statement of financial position At 31 Dec 2025 $m At 31 Dec 2024 $m Current assets 34 54 Non-current assets 124 - Current liabilities (2,975) (2,347) Non-current liabilities (24,687) (26,603) Amounts due from subsidiaries that are not issuers or guarantors 19,322 18,272 Amounts due to subsidiaries that are not issuers or guarantors - - ===== SIDA 22 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 22 Capital allocation The Group’s capital allocation priorities include: investing in the business and pipeline; maintaining a strong, investment- grade credit rating; potential value- enhancing business development opportunities; and supporting the progressive dividend policy. In approving the declaration of dividends, the Board considers both the liquidity of the Company and the level of reserves legally available for distribution. In FY 2026, the Company intends to increase the annual dividend declared to $3.30 per share. Dividends are paid to shareholders from AstraZeneca PLC, a Group holding company with no direct operations. The ability of AstraZeneca PLC to make shareholder distributions is dependent on the creation of profits for distribution and the receipt of funds from subsidiary companies. The consolidated Group reserves set out in the Condensed consolidated statement of financial position do not reflect the profit available for distribution to the shareholders of AstraZeneca PLC. In FY 2025, capital expenditure on tangible assets and Software-related intangible assets amounted to $3,270m. In FY 2026 the Group expects to increase expenditure on tangible assets and Software-related intangible assets by approximately a third driven by manufacturing expansion projects and investments in systems and technology. Foreign exchange The Company's transactional currency exposures on working capital balances, which typically extend for up to three months, are hedged where practicable using forward foreign exchange contracts against the individual companies' reporting currency. Foreign exchange gains and losses on forward contracts transacted for transactional hedging are taken to profit or to Other comprehensive income if the contract is in a designated cashflow hedge. In addition, the Company's external dividend payments, paid principally in pound sterling and Swedish krona, are fully hedged from the time of their announcement to the payment date. Table 16: Currency sensitivities Currency Primary Relevance Exchange rate vs USD (average rate in period) Annual impact of 5% strengthening vs USD1 ($m) FY 20252 YTD 20263 Change (%) At 30 Jan 20264 Change (%) Total Revenue Core Operating Profit EUR Total Revenue 0.88 0.85 4 0.84 6 499 234 CNY Total Revenue 7.19 6.97 3 6.95 4 329 178 JPY Total Revenue 149.64 156.99 (5) 153.77 (3) 179 120 GBP Operating expense 0.76 0.74 2 0.73 4 50 (180) SEK Operating expense 9.81 9.12 8 8.85 11 9 (71) Other 615 339 1. Assumes the average exchange rate vs USD in FY 2026 is 5% higher than the average rate in FY 2025. The impact data are estimates, based on best prevailing assumptions around currency profiles. 2. Based on average daily spot rates 1 January 2025 to 31 December 2025. 3. Based on average daily spot rates 1 January 2026 to 30 January 2026. 4. Based on average daily spot rates on 30 January 2026. ===== SIDA 23 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 23 Table 17: Condensed consolidated statement of comprehensive income: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m - Product Sales 55,573 50,938 - Alliance Revenue 3,067 2,212 Product Revenue 58,640 53,150 Collaboration Revenue 99 923 Total Revenue 58,739 54,073 Cost of sales (10,633) (10,207) Gross profit 48,106 43,866 Distribution expense (579) (555) Research and development expense (14,232) (13,583) Selling, general and administrative expense (19,933) (19,977) Other operating income and expense 381 252 Operating profit 13,743 10,003 Finance income 360 458 Finance expense (1,694) (1,742) Share of after tax losses in associates and joint ventures (7) (28) Profit before tax 12,402 8,691 Taxation (2,169) (1,650) Profit for the period 10,233 7,041 Other comprehensive income Items that will not be reclassified to profit or loss: Remeasurement of the defined benefit pension liability 290 80 Net gains on equity investments measured at fair value through Other comprehensive income 188 139 Fair value movements related to own credit risk on bonds designated as fair value through profit or loss - 12 Tax expense on items that will not be reclassified to profit or loss (94) (43) 384 188 Items that may be reclassified subsequently to profit or loss: Foreign exchange arising on consolidation 2,387 (957) Foreign exchange arising on designated liabilities in net investment hedges 18 (122) Fair value movements on cash flow hedges 263 (129) Fair value movements on cash flow hedges transferred to profit and loss (314) 177 Fair value movements on derivatives designated in net investment hedges 14 39 Gains/(costs) of hedging 1 (21) Tax (expense)/income on items that may be reclassified subsequently to profit or loss (50) 25 2,319 (988) Other comprehensive income/(expense) for the period, net of tax 2,703 (800) Total comprehensive income for the period 12,936 6,241 Profit attributable to: Owners of the Parent 10,225 7,035 Non-controlling interests 8 6 10,233 7,041 Total comprehensive income attributable to: Owners of the Parent 12,920 6,236 Non-controlling interests 16 5 12,936 6,241 Earnings per share Basic earnings per $0.25 Ordinary Share $6.60 $4.54 Diluted earnings per $0.25 Ordinary Share $6.54 $4.50 Weighted average number of Ordinary Shares in issue (millions) 1,550 1,550 Diluted weighted average number of Ordinary Shares in issue (millions) 1,562 1,563 Condensed consolidated financial statements ===== SIDA 24 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 24 Table 18: Condensed consolidated statement of comprehensive income: Q4 2025 For the quarter ended 31 December 2025 $m 2024 $m - Product Sales 14,538 13,362 - Alliance Revenue 959 714 Product Revenue 15,497 14,076 Collaboration Revenue 6 815 Total Revenue 15,503 14,891 Cost of sales (3,118) (2,725) Gross profit 12,385 12,166 Distribution expense (153) (143) Research and development expense (3,862) (4,677) Selling, general and administrative expense (5,492) (5,410) Other operating income and expense 100 100 Operating profit 2,978 2,036 Finance income 135 64 Finance expense (484) (429) Share of after tax losses in associates and joint ventures - (5) Profit before tax 2,629 1,666 Taxation (300) (166) Profit for the period 2,329 1,500 Other comprehensive income/(expense) Items that will not be reclassified to profit or loss: Remeasurement of the defined benefit pension liability 174 (56) Net gains/(losses) on equity investments measured at fair value through Other comprehensive income 209 (125) Fair value movements related to own credit risk on bonds designated as fair value through profit or loss - - Tax (expense)/income on items that will not be reclassified to profit or loss (81) 7 302 (174) Items that may be reclassified subsequently to profit or loss: Foreign exchange arising on consolidation 120 (1,500) Foreign exchange arising on designated liabilities in net investment hedges 4 (38) Fair value movements on cash flow hedges 6 (87) Fair value movements on cash flow hedges transferred to profit and loss 4 176 Fair value movements on derivatives designated in net investment hedges 21 26 Costs of hedging (7) (23) Tax income on items that may be reclassified subsequently to profit or loss - 9 148 (1,437) Other comprehensive income/(expense) for the period, net of tax 450 (1,611) Total comprehensive income/(expense) for the period 2,779 (111) Profit attributable to: Owners of the Parent 2,326 1,500 Non-controlling interests 3 - 2,329 1,500 Total comprehensive income/(expense) attributable to: Owners of the Parent 2,770 (110) Non-controlling interests 9 (1) 2,779 (111) Earnings per share Basic earnings per $0.25 Ordinary Share $1.50 $0.97 Diluted earnings per $0.25 Ordinary Share $1.49 $0.96 Weighted average number of Ordinary Shares in issue (millions) 1,551 1,550 Diluted weighted average number of Ordinary Shares in issue (millions) 1,563 1,562 ===== SIDA 25 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 25 Table 19: Condensed consolidated statement of financial position At 31 Dec 2025 At 31 Dec 2024 Assets $m $m Non-current assets Property, plant and equipment 12,962 10,252 Right-of-use assets 1,741 1,395 Goodwill 21,242 21,025 Intangible assets 37,846 37,177 Investments in associates and joint ventures 302 268 Other investments 2,223 1,632 Derivative financial instruments 498 182 Other receivables 1,327 930 Income tax receivable 1,391 - Deferred tax assets 5,819 5,347 85,351 78,208 Current assets Inventories 6,557 5,288 Trade and other receivables 15,177 12,972 Other investments 30 166 Derivative financial instruments 90 54 Income tax receivable 1,158 1,859 Cash and cash equivalents 5,711 5,488 28,723 25,827 Total assets 114,074 104,035 Liabilities Current liabilities Interest-bearing loans and borrowings (3,104) (2,337) Lease liabilities (382) (339) Trade and other payables (25,280) (22,465) Derivative financial instruments (81) (50) Provisions (686) (1,269) Income tax payable (1,084) (1,406) (30,617) (27,866) Non-current liabilities Interest-bearing loans and borrowings (24,715) (26,506) Lease liabilities (1,421) (1,113) Derivative financial instruments - (115) Deferred tax liabilities (3,500) (3,305) Retirement benefit obligations (1,105) (1,330) Provisions (918) (921) Income tax payable (700) (238) Other payables (2,379) (1,770) (34,738) (35,298) Total liabilities (65,355) (63,164) Net assets 48,719 40,871 Equity Share capital 388 388 Share premium account 35,266 35,226 Other reserves 2,041 2,012 Retained earnings 10,972 3,160 Capital and reserves attributable to equity holders of the Parent 48,667 40,786 Non-controlling interests 52 85 Total equity 48,719 40,871 ===== SIDA 26 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 26 Table 20: Condensed consolidated statement of changes in equity Share capital Share premium account Other reserves Retained earnings Total attributable to owners of the Parent Non- controlling interests Total equity $m $m $m $m $m $m $m At 1 Jan 2024 388 35,188 2,065 1,502 39,143 23 39,166 Profit for the period - - - 7,035 7,035 6 7,041 Other comprehensive expense - - - (799) (799) (1) (800) Transfer to Other reserves - - 15 (15) - - - Transactions with owners Dividends - - - (4,602) (4,602) - (4,602) Dividends paid to non-controlling interests - - - - - (4) (4) Issue of Ordinary Shares - 38 - - 38 - 38 Changes in non-controlling interests - - - - - 61 61 Movement in shares held by Employee Benefit Trusts - - (68) - (68) - (68) Share-based payments charge for the period - - - 660 660 - 660 Settlement of share plan awards - - - (621) (621) - (621) Net movement - 38 (53) 1,658 1,643 62 1,705 At 31 Dec 2024 388 35,226 2,012 3,160 40,786 85 40,871 At 1 Jan 2025 388 35,226 2,012 3,160 40,786 85 40,871 Profit for the period - - - 10,225 10,225 8 10,233 Other comprehensive (expense)/income - - (61) 2,756 2,695 8 2,703 Transfer to Other reserves - - 47 (47) - - - Transactions with owners Dividends - - - (4,846) (4,846) - (4,846) Dividends paid to non-controlling interests - - - - - (6) (6) Issue of Ordinary Shares - 40 - - 40 - 40 Changes in non-controlling interests - - - (214) (214) (43) (257) Movement in shares held by Employee Benefit Trusts - - 43 - 43 - 43 Share-based payments charge for the period - - - 719 719 - 719 Settlement of share plan awards - - - (781) (781) - (781) Net movement - 40 29 7,812 7,881 (33) 7,848 At 31 Dec 2025 388 35,266 2,041 10,972 48,667 52 48,719 Transfer to other reserves includes $70m in respect of the opening balance on the Cash flow hedge reserve. The cash flow hedge reserve was previously disclosed within Retained earnings but from 2025 is disclosed within Other reserves. ===== SIDA 27 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 27 Table 21: Condensed consolidated statement of cash flows: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m Cash flows from operating activities Profit before tax 12,402 8,691 Finance income and expense 1,334 1,284 Share of after tax losses of associates and joint ventures 7 28 Depreciation, amortisation and impairment 5,733 6,688 Movement in working capital and short-term provisions (1,137) (893) Gains on disposal of intangible assets (168) (64) Fair value movements on contingent consideration arising from business combinations (97) 311 Non-cash and other movements 662 (121) Cash generated from operations 18,736 15,924 Interest paid (1,316) (1,313) Tax paid (2,845) (2,750) Net cash inflow from operating activities 14,575 11,861 Cash flows from investing activities Acquisition of subsidiaries, net of cash acquired (66) (2,771) Payments upon vesting of employee share awards attributable to business combinations - (3) Payment of contingent consideration from business combinations (1,164) (1,008) Purchase of property, plant and equipment (2,810) (1,924) Disposal of property, plant and equipment 13 55 Purchase of intangible assets (3,095) (2,662) Disposal of intangible assets 136 123 Purchase of non-current asset investments (229) (96) Disposal of non-current asset investments - 78 Movement in short-term investments, fixed deposits and other investing instruments 131 30 Payments to associates and joint ventures (10) (158) Disposal of investments in associates and joint ventures - 13 Interest received 286 343 Net cash outflow from investing activities (6,808) (7,980) Net cash inflow before financing activities 7,767 3,881 Cash flows from financing activities Proceeds from issue of share capital 40 38 Own shares purchased by Employee Benefit Trusts (521) (81) Payments to acquire non-controlling interests (183) - Issue of loans and borrowings 15 6,492 Repayment of loans and borrowings (2,029) (4,652) Dividends paid (4,971) (4,629) Hedge contracts relating to dividend payments 113 16 Repayment of obligations under leases (372) (316) Movement in short-term borrowings 364 (31) Payment of Acerta Pharma share purchase liability - (833) Net cash outflow from financing activities (7,544) (3,996) Net increase/(decrease) in Cash and cash equivalents in the period 223 (115) Cash and cash equivalents at the beginning of the period 5,429 5,637 Exchange rate effects 46 (93) Cash and cash equivalents at the end of the period 5,698 5,429 Cash and cash equivalents consist of: Cash and cash equivalents 5,711 5,488 Overdrafts (13) (59) 5,698 5,429 ===== SIDA 28 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 28 Note 1: Basis of preparation and accounting policies These Condensed consolidated financial statements for the twelve months ended 31 December 2025 have been prepared in accordance with UK-adopted international accounting standards and with the requirements of the Companies Act 2006 as applicable to companies reporting under those standards. The Condensed consolidated financial statements also comply fully with IFRS Accounting Standards as issued by the International Accounting Standards Board (IASB) and International Accounting Standards as adopted by the European Union. These Condensed consolidated financial statements comprise the financial results of AstraZeneca PLC for the years to 31 December 2025 and 2024 together with the Statement of financial position as at 31 December 2025 and 2024. The results for the year to 31 December 2025 have been extracted from the 31 December 2025 audited consolidated financial statements which have been approved by the Board of Directors. These have not yet been delivered to the Registrar of Companies but are expected to be published on 24 February 2026 within the Annual Report and Form 20-F Information 2025. The financial information set out above does not constitute the Group’s statutory accounts for the years to 31 December 2025 or 2024 but is derived from these accounts. The auditors have reported on those accounts: their reports (i) were unqualified, (ii) did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying their report and (iii) did not contain a statement under section 498 (2) or (3) of the Companies Act 2006 in respect of the accounts for the year to 31 December 2025 or for 31 December 2024. Statutory accounts for the year to 31 December 2025 were approved by the Board of Directors for release on 10 February 2026. Amendments to accounting standards issued by the IASB and adopted in the year ended 31 December 2025 did not have a material impact on the result or financial position of the Group and the Condensed consolidated financial statements have been prepared applying the accounting policies that were applied in the preparation of the Group’s published consolidated financial statements for the year ended 31 December 2024. The comparative figures for the financial year ended 31 December 2024 are not the Group’s statutory accounts for that financial year. Those accounts have been reported on by the Group’s auditors and have been delivered to the Registrar of Companies; their report (i) was unqualified, (ii) did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying their report, and (iii) did not contain a statement under section 498(2) or (3) of the Companies Act 2006. Product Revenue Effective 1 January 2025, the Group has updated the presentation of Total Revenue on the face of the Statement of Comprehensive Income to include a new subtotal ‘Product Revenue’ representing the summation of Product Sales and Alliance Revenue. Product Revenue and Collaboration Revenue form Total Revenue. Product Sales and Alliance Revenue will continue to be presented separately, with the new subtotal providing additional aggregation of revenue types with similar characteristics, reflecting the growing importance of Alliance Revenue. Full descriptions of Product Sales, Alliance Revenue and Collaboration Revenue are included from page 152 of the Group's Annual Report and Form 20-F Information 2024. There are no changes to the Revenue accounting policy regarding the types of transactions recorded in each revenue category. The comparative period has been retrospectively adjusted to reflect the additional subtotal, resulting in total Product Revenue being reported for the twelve months ended 31 December 2024 of $53,150m. Going concern The Group has considerable financial resources available. As at 31 December 2025, the Group has $10.6bn in financial resources (cash and cash equivalent balances of $5.7bn and undrawn committed bank facilities of $4.9bn that are available until April 2030), with $3.5bn of borrowings due within one year. These facilities contain no financial covenants, and in January 2026 their maturity was extended to April 2031. The Group has assessed the prospects of the Group over a period longer than the required 12 months from the date of Board approval of these consolidated financial statements, with no deterioration noted requiring a further extension of this review. The Group's revenues are largely derived from sales of medicines covered by patents, which provide a relatively high level of resilience and predictability to cash inflows, although government price interventions in response to budgetary constraints are expected to continue to adversely affect revenues in some of our significant markets. The Group, however, anticipates new revenue streams from both recently launched medicines and those in development, and the Group has a wide diversity of customers and suppliers across different geographic areas. Consequently, the Directors believe that, overall, the Group is well placed to manage its business risks successfully. Accordingly, they continue to adopt the going concern basis in preparing the Interim financial statements. Legal proceedings The information contained in Note 5 updates the disclosures concerning legal proceedings and contingent liabilities in the Group's Annual Report and Form 20-F Information 2024. Notes to the Condensed consolidated financial statements ===== SIDA 29 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 29 Note 2: Intangible assets In accordance with IAS 36 ‘Impairment of Assets’, reviews for triggers of impairment or impairment reversals at an individual asset or cash generating unit level were conducted, and impairment tests carried out where triggers were identified. In 2025, the Group recorded impairment charges of $8m (2024: $504m) in respect of launched products. Impairment charges recorded against products in development totalled $210m (2024: $1,073m). EsoBiotec The acquisition of EsoBiotec completed on 19 May 2025. The transaction is recorded as an asset acquisition based upon the concentration test permitted under IFRS 3 ‘Business Combinations’, with consideration and net assets acquired of $403m, which included intangible assets acquired of $426m. Contingent consideration of up to $575m could be paid on achievement of regulatory milestones, those liabilities will be recorded when the relevant regulatory milestones are achieved. Agreement with Merck on Koselugo Intangible asset additions of $536m in the third quarter relate to the total of net upfront payment made, the present value of non-contingent future payments and a sales-related payment due to Merck & Co., Inc. (Merck) in connection with the restructuring of arrangements relating to Koselugo, recorded as an asset acquisition. A regulatory milestone of $50m, and sales- related payment of $35m additionally fell due and were capitalised in the third quarter. Two more regulatory milestones totalling $125m were achieved and capitalised in the fourth quarter. Further contingent payments of up to $175m could be paid on achievement of regulatory milestones or on achievement of sales-related thresholds. Those liabilities will be recorded when milestones are triggered, or performance conditions have been satisfied. Sales-related payments are accrued and capitalised when considered probable with reference to the latest Group sales forecasts for approved indications at the present value of expected future cash flows. Note 3: Net debt Table 22: Net debt At 1 Jan 2025 Cash flow Acquisitions Non-cash and other Exchange movements At 31 Dec 2025 $m $m $m $m $m $m Non-current instalments of loans (26,506) - - 2,418 (627) (24,715) Non-current instalments of leases (1,113) - - (259) (49) (1,421) Total long-term debt (27,619) - - 2,159 (676) (26,136) Current instalments of loans (2,007) 2,014 - (2,467) - (2,460) Current instalments of leases (339) 449 (1) (472) (19) (382) Collateral received from derivative counterparties (181) (292) - - - (473) Other short-term borrowings excluding overdrafts (90) (72) - - 4 (158) Overdrafts (59) 47 - - (1) (13) Total current debt (2,676) 2,146 (1) (2,939) (16) (3,486) Gross borrowings (30,295) 2,146 (1) (780) (692) (29,622) Net derivative financial instruments 71 (346) - 782 - 507 Net borrowings (30,224) 1,800 (1) 2 (692) (29,115) Cash and cash equivalents 5,488 56 120 - 47 5,711 Other investments - current 166 (131) - - (5) 30 Cash and investments 5,654 (75) 120 - 42 5,741 Net debt (24,570) 1,725 119 2 (650) (23,374) The table above provides an analysis of Net debt and a reconciliation of Net cash flow to the movement in Net debt. The Group monitors Net debt as part of its capital management policy as described in Note 28 of the Annual Report and Form 20-F Information 2024. Net debt is a non- GAAP financial measure. Net debt decreased by $1,196m in the twelve months to 31 December 2025 to $23,374m. Details of the committed undrawn bank facilities are disclosed within the going concern section of Note 1. Non-cash movements in the period include fair value adjustments under IFRS 9 'Financial Instruments'. The Group has agreements with some bank counterparties whereby the parties agree to post cash collateral on financial derivatives, for the benefit of the other, equivalent to the market valuation of the derivative positions above a predetermined threshold. The carrying value of such cash collateral held by the Group at 31 December 2025 was $473m (31 December 2024 : $181m ) and the carrying value of such cash collateral posted by the Group at 31 December 2025 was $22m (31 December 2024 : $129m). The equivalent GAAP measure to Net debt is 'liabilities arising from financing activities', which excludes the amounts for cash and overdrafts, other investments and non-financing derivatives above. During the twelve months ended 31 December 2025, Moody’s upgraded the Group’s solicited long term credit rating to A1 from A2, which occurred during Q1 2025. The short term rating remained at P-1. There were no changes to Standard and Poor’s credit ratings (long term: A+; short term: A-1). ===== SIDA 30 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 30 Note 4: Financial Instruments As detailed in the Group's most recent annual financial statements, the principal financial instruments consist of derivative financial instruments, other investments, trade and other receivables, cash and cash equivalents, trade and other payables, lease liabilities and interest-bearing loans and borrowings. The Group has certain equity investments that are categorised as Level 3 in the fair value hierarchy that are held at $458m (31 December 2024: $353m) and for which a fair value loss of $50m has been recognised in the twelve months ended 31 December 2025 (FY 2024: $9m). In the absence of specific market data, these unlisted investments are held at fair value based on the cost of investment and adjusted as necessary for impairments and revaluations on new funding rounds, which are seen to approximate the fair value. All other fair value gains and/or losses that are presented in Net gains on equity investments measured at fair value through other comprehensive income, in the Condensed consolidated statement of comprehensive income for the twelve months ended 31 December 2025 are Level 1 fair value measurements, valued based on quoted prices in active markets. Financial instruments measured at fair value include $2,231m of other investments, $4,224m held in money- market funds and $507m of derivatives as at 31 December 2025. With the exception of derivatives being Level 2 fair valued, and certain equity instruments of $458m categorised as Level 3, the aforementioned balances are Level 1 fair valued. Financial instruments measured at amortised cost include $22m of cash collateral pledged to counterparties. The total fair value of Interest-bearing loans and borrowings as at 31 December 2025, which have a carrying value of $29,622m in the Condensed consolidated statement of financial position, was $29,221m. Contingent consideration arising from business combinations is fair valued using decision-tree analysis, with key inputs including the probability of success, consideration of potential delays and the expected levels of future revenues. The contingent consideration balance relating to BMS's share of the global diabetes alliance of $257m (31 December 2024: $1,309m) is due for final payment in 2026. Table 23: Contingent consideration 2025 2024 Diabetes alliance $m Other $m Total $m Total $m At 1 January 1,309 442 1,751 2,137 Additions through business combinations - - - 198 Settlements (1,054) (110) (1,164) (1,008) Revaluations (44) (53) (97) 311 Discount unwind 46 14 60 113 At 31 December 257 293 550 1,751 Note 5: Legal proceedings and contingent liabilities AstraZeneca is involved in various legal proceedings considered typical to its business, including litigation and investigations, including Government investigations, relating to product liability, commercial disputes, infringement of intellectual property (IP) rights, the validity of certain patents, anti-trust law and sales and marketing practices. The matters discussed below constitute the more significant developments since publication of the disclosures concerning legal proceedings in the Company's Annual Report and Form 20-F Information 2024, the H1 2025 and the Q3 2025 results announcements (the Disclosures). Information about the nature and facts of the cases is disclosed in accordance with IAS 37 ‘Provisions, Contingent Liabilities and Contingent Assets’. As discussed in the Disclosures, the majority of claims involve highly complex issues. Often these issues are subject to substantial uncertainties and, therefore, the probability of a loss, if any, being sustained and/or an estimate of the amount of any loss is difficult to ascertain. In cases that have been settled or adjudicated, or where quantifiable fines and penalties have been assessed and which are not subject to appeal, or where a loss is probable and we are able to make a reasonable estimate of the loss, AstraZeneca records the loss absorbed or makes a provision for its best estimate of the expected loss. The position could change over time and the estimates that the Company made, and upon which the Company have relied in calculating these provisions are inherently imprecise. There can, therefore, be no assurance that any losses that result from the outcome of any legal proceedings will not exceed the amount of the provisions that have been booked in the accounts. The major factors causing this uncertainty are described more fully in the Disclosures and herein. AstraZeneca has full confidence in, and will vigorously defend and enforce, its IP. ===== SIDA 31 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 31 Matters disclosed in respect of the fourth quarter of 2025 and to 10 February 2026 Table 24: Patent litigation Legal proceedings brought against AstraZeneca Enhertu patent proceedings, US Considered to be a contingent liability  In October 2020, Seagen Inc. (Seagen) filed a complaint against Daiichi Sankyo Company, Limited (Daiichi Sankyo) in the US District Court for the Eastern District of Texas (District Court) alleging that Enhertu infringes a Seagen patent. AstraZeneca co-commercialises Enhertu with Daiichi Sankyo in the US. After trial in April 2022, the jury found that the patent was infringed and awarded Seagen $41.82m in past damages. In July 2022, the District Court entered final judgment and declined to enhance damages on the basis of wilfulness. In October 2023, the District Court entered an amended final judgment that requires Daiichi Sankyo to pay Seagen a royalty of 8% on US sales of Enhertu from 1 April 2022 through to 4 November 2024, in addition to the past damages previously awarded by the District Court. AstraZeneca and Daiichi Sankyo have appealed the District Court’s decision.  In December 2020 and January 2021, AstraZeneca and Daiichi Sankyo filed post-grant review (PGR) petitions with the US Patent and Trademark Office (USPTO) alleging, among other things, that the Seagen patent is invalid for lack of written description and enablement. The USPTO initially declined to institute the PGRs, but, in April 2022, the USPTO granted the rehearing requests and instituted both PGR petitions. Seagen subsequently disclaimed all patent claims at issue in one of the PGR proceedings. In July 2022, the USPTO reversed its institution decision and declined to institute the other PGR petition. AstraZeneca and Daiichi Sankyo requested reconsideration of the decision not to institute review of the patent. In February 2023, the USPTO reinstituted the PGR proceeding. In February 2024, the USPTO issued a decision that the claims were unpatentable. Seagen has appealed this decision; the USPTO has intervened in the appeal.  In December 2025, the US Court of Appeals for the Federal Circuit issued decisions in both the District Court and PGR appeals finding that Seagen's patent is invalid and vacating the District Court’s prior judgment and damages award. Forxiga patent proceedings, Europe Considered to be a contingent liability  In November 2025, in France, Biogaran SAS challenged one of AstraZeneca's patents covering Forxiga. No trial date has been set.  In Poland and in Portugal, multiple generic companies have challenged one of AstraZeneca's patents covering Forxiga. No trial date has been set.  In Poland, in January 2026, AstraZeneca obtained interim injunctions against the generic companies that have challenged the patent. Tagrisso patent proceedings, China Considered to be a contingent liability  In January 2025, an individual filed invalidity challenges against several Chinese patents protecting Tagrisso.  A hearing before the Chinese Patent Office (Patent Office) was held in July 2025.  In November 2025, the Patent Office issued decisions maintaining the compound patents.  In January 2026, the Patent Office dismissed the invalidity case against the formulation patent. Legal proceedings brought by AstraZeneca Calquence patent proceedings, US Considered to be a contingent asset  AstraZeneca received Paragraph IV notices relating to patents listed in the FDA Orange Book with reference to Calquence tablets from Cipla USA, Inc. and Cipla Limited (collectively, Cipla) in April 2024 and from MSN Pharmaceuticals Inc. and MSN Laboratories Pvt. Ltd. (collectively, MSN) in November 2024.  In response to these Paragraph IV notices, AstraZeneca filed patent infringement lawsuits against Cipla in May 2024 and against MSN in January 2025 in the US District Court for the District of Delaware (District Court). In the complaints, AstraZeneca alleges that a generic version of Calquence tablets, if approved and marketed, would infringe patents that are owned or licensed by AstraZeneca. Trial has been scheduled for April 2027.  In December 2025, AstraZeneca entered into a settlement agreement with MSN and the District Court dismissed the corresponding litigation. The litigation with Cipla is ongoing. Forxiga patent proceedings, Australia Considered to be a contingent asset  In December 2025, in the Federal Court of Australia, AstraZeneca initiated patent infringement litigation against Pharmacor Pty Limited in reference to one of the patents that protects Forxiga.  No trial date has been set. ===== SIDA 32 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 32 Table 25: Product liability litigation Legal proceedings brought against AstraZeneca Farxiga and Xigduo XR, US Considered to be a contingent liability  AstraZeneca has been named as a defendant in lawsuits involving plaintiffs claiming physical injury, including Fournier’s Gangrene and necrotising fasciitis, from treatment with Farxiga and/or Xigduo XR.  The parties have reached a settlement in principle for a non-material amount to resolve the single case scheduled for trial in March 2026.  All remaining claims are filed in Delaware State Court and the earliest trial is now scheduled for September 2026. Table 26: Commercial litigation Legal proceedings brought against AstraZeneca Anti-Terrorism Act Civil Lawsuit, US Considered to be a contingent liability  In the US, in October 2017, AstraZeneca and certain other pharmaceutical and/or medical device companies were named as defendants in a complaint filed in the US District Court for the District of Columbia (District Court) by US nationals (or their estates, survivors, or heirs) who were killed or wounded in Iraq between 2005 and 2013. The plaintiffs allege that the defendants violated the US Anti-Terrorism Act and various state laws by selling pharmaceuticals and medical supplies to the Iraqi Ministry of Health. In July 2020, the District Court granted AstraZeneca’s and the other defendants’ motion to dismiss the lawsuit, which the DC Circuit Court of Appeals (the Appellate Court) reversed in January 2022.  In June 2024, the United States Supreme Court issued an order vacating the 2022 decision and remanding to the Appellate Court for reconsideration under new case law. In January 2026, after reconsideration, the Second Circuit issued a decision again allowing the claims to proceed and returning the matter to the District Court, where AstraZeneca has a separate motion to dismiss pending. Definiens, Germany Considered to be a contingent liability  In July 2020, AstraZeneca received a notice of arbitration filed with the German Institution of Arbitration from the sellers of Definiens AG (Sellers) regarding the 2014 share purchase agreement (SPA) between AstraZeneca and the Sellers. The Sellers claim that they are owed approximately $140m in earn-outs under the SPA. In December 2023, after an arbitration hearing, the arbitration panel made a final award of $46m in favour of the Sellers.  In March 2024, AstraZeneca filed an application with the Bavarian Supreme Court (Court) to set aside the arbitration award.  In April 2025, the Court ruled in favour of AstraZeneca, annulled the arbitration award, and referred the dispute back to the same arbitration panel for a second determination.  In May 2025, the Sellers appealed the Court's decision to the German Federal Court of Justice (Court of Justice). AstraZeneca also appealed the decision to refer the dispute back to the same arbitration panel.  In January 2026, the Court of Justice upheld the Court’s decision to annul the arbitration award and referred the dispute back to the same arbitration panel. Novartis Advertising Litigation, US Considered to be a contingent liability  In October 2025, Novartis Pharmaceuticals Corp. filed a lawsuit in the US District Court for the District of Delaware alleging false and misleading representation claims under the Lanham Act and state law unfair competition and deceptive practices claims.  The complaint alleges that statements in AstraZeneca's marketing for treatment for paroxysmal nocturnal hemoglobinuria are false and misleading. Soliris Antitrust Class Action, US Considered to be a contingent liability  In April 2025, AstraZeneca was named in a lawsuit filed in the US District Court for the District of Massachusetts (District Court) alleging antitrust claims on behalf of a potential class of end payors for Soliris from March 2022.  The plaintiff alleges that AstraZeneca violated federal and state antitrust and business practices laws by obtaining improper patents for Soliris, delaying biosimilar entry and improperly extending Soliris’ market exclusivity.  In December 2025, the District Court partially granted AstraZeneca's motion to dismiss. ===== SIDA 33 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 33 Table 27: Government investigations and proceedings Legal proceedings brought against AstraZeneca China Personal Information Infringement and Illegal Trade Matters, China Considered to be a contingent liability  In relation to the personal information infringement allegation, in April 2025, AstraZeneca Investment (China) Co., Ltd. received a Notice of Transfer to the Prosecutor from the Shenzhen Bao’an District Public Security Bureau regarding suspected unlawful collection of personal information.  In relation to the illegal trade allegation, in October 2025, AstraZeneca Investment (China) Co., Ltd. received a final appraisal opinion from the Shenzhen City Customs Office, informing AstraZeneca Investment (China) Co., Ltd. that the total amount of unpaid import taxes is RMB 24m (approximately USD $3.5m). The import taxes mentioned in the Appraisal Opinion relate to Imfinzi, Imjudo, and Enhertu. In October 2025, AstraZeneca Investment (China) Co., Ltd. prepaid the full amount as voluntary compensation to the State. A fine of between one and five times the amount of these paid importation taxes may also be levied if AstraZeneca Investment (China) Co., Ltd. is found liable for illegal trade.  In November 2025, the Shenzhen Prosecutor concluded its evaluation. AstraZeneca Investment (China) Co., Ltd., the former EVP and one former senior employee were indicted on charges of unlawful collection of personal information and illegal trade, although no illegal gain to AstraZeneca Investment (China) Co., Ltd. was alleged resulting from unlawful collection of personal information.  The former EVP and former senior employee were additionally indicted on charges of medical insurance fraud. AstraZeneca Investment (China) Co., Ltd. has not been indicted on charges of medical insurance fraud.  The matters have been consolidated into one proceeding before the Shenzhen City Intermediate Court. No trial date has been scheduled. Legal proceedings brought by AstraZeneca 340B State Litigation, US Considered to be a contingent asset  AstraZeneca has filed lawsuits against Arkansas, Colorado, Hawaii, Kansas, Louisiana, Maine, Maryland, Minnesota, Mississippi, Missouri, Nebraska, New Mexico, North Dakota, Oklahoma, Oregon, Rhode Island, South Dakota, Tennessee, Utah, Vermont, and West Virginia challenging the constitutionality of each state’s 340B statute.  AstraZeneca has ongoing enforcement actions in Arkansas and Louisiana for alleged non- compliance with each state's 340B statute. In April 2025, an order was issued in the Arkansas proceeding requiring AstraZeneca to pause its contract pharmacy policy, which AstraZeneca has appealed.  In Arkansas, the Court denied a motion to dismiss.  In Colorado, the Court denied AstraZeneca's motion for a preliminary injunction, which AstraZeneca has appealed.  In Kansas, after obtaining a stipulation from the state that AstraZeneca’s policy does not violate the Kansas 340B statute, AstraZeneca agreed to dismiss its complaint.  In Louisiana, the Court denied AstraZeneca’s motion for summary judgement, which AstraZeneca has appealed.  In Maryland and Mississippi, the Court denied AstraZeneca’s motion for a preliminary injunction.  In Minnesota, the Court found that the government officials lacked enforcement authority and dismissed AstraZeneca's complaint for lack of standing.  In Missouri, the Court granted in part and denied in part the state’s motion to dismiss.  In Oklahoma, the Court granted AstraZeneca's motion for a preliminary injunction, which Oklahoma has appealed.   AstraZeneca’s lawsuits are stayed in Rhode Island, Utah, and West Virginia. Calquence Inflation Reduction Act Litigation, US Considered to be a contingent asset  In December 2025, AstraZeneca filed a lawsuit in the US District Court for the District of Maryland challenging the US Department of Health and Human Services’ interpretation of “qualifying single source drug” under the Inflation Reduction Act and its application in selecting Calquence for drug price negotiation. Other Additional government inquiries As is true for most, if not all, major prescription pharmaceutical companies, AstraZeneca is currently involved in multiple inquiries into drug marketing and pricing practices. In addition to the investigations described above, various law enforcement offices have, from time to time, requested information from the Group. There have been no material developments in those matters. ===== SIDA 34 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 34 Note 6: Analysis of Revenue and Other operating income and expense Table 28: Product Sales year-on-year analysis: FY 2025 CER information in respect of FY 2025 included in the Consolidated Financial Information has not been audited by PricewaterhouseCoopers LLP. For the twelve months World US Emerging Markets Europe Established RoW ended 31 December Change Change Change Change Change $m Act % CER % $m Act % $m Act % CER % $m Act % CER % $m Act % CER % Tagrisso 7,254 10 10 3,064 11 1,971 12 14 1,423 9 6 796 5 5 Imfinzi 6,063 29 28 3,509 35 640 34 38 1,239 31 26 675 (2) (2) Calquence 3,518 12 12 2,339 7 233 52 54 784 20 15 162 25 27 Lynparza 3,279 7 6 1,434 8 669 2 1 914 10 6 262 3 4 Enhertu 977 79 81 - - 668 91 95 207 64 58 102 47 51 Zoladex 1,106 5 6 19 17 842 6 8 157 6 3 88 (11) (10) Truqap 728 69 68 586 44 23 n/m n/m 85 n/m n/m 34 n/m n/m Imjudo 346 23 23 227 26 22 40 43 52 43 38 45 (9) (9) Datroway 2 n/m n/m - n/m 2 n/m n/m - n/m n/m - n/m n/m Other Oncology 425 (8) (8) 9 (52) 280 (6) (4) 19 (17) (19) 117 (6) (7) Oncology 23,698 17 16 11,187 18 5,350 19 21 4,880 20 15 2,281 5 5 Farxiga 8,400 10 9 1,730 (1) 3,324 17 18 2,941 12 8 405 (3) (3) Crestor 1,216 5 6 45 (3) 1,041 11 12 1 (97) (97) 129 (5) (5) Brilinta 823 (38) (38) 393 (48) 273 (7) (7) 147 (45) (46) 10 (51) (48) Lokelma 698 29 28 301 18 129 50 52 129 39 34 139 29 28 Seloken 607 - 2 - - 586 (1) 1 18 43 43 3 1 14 roxadustat 274 (17) (17) - - 274 (17) (17) - - - - - - Wainua 212 n/m n/m 204 n/m 4 n/m n/m 4 n/m n/m - - - Other CVRM 534 (28) (28) 49 (74) 262 4 5 158 (30) (32) 65 (17) (17) CVRM 12,764 3 2 2,722 (11) 5,893 10 12 3,398 4 - 751 (2) (2) Symbicort 2,885 - - 1,193 1 801 (1) 1 560 - (3) 331 1 3 Fasenra 1,981 17 16 1,195 14 117 27 29 482 19 15 187 29 30 Breztri 1,199 23 22 614 19 298 22 22 191 33 29 96 30 30 Tezspire 458 85 80 - - 40 n/m n/m 297 90 83 121 51 51 Saphnelo 686 45 44 596 40 16 n/m n/m 49 89 81 25 52 52 Pulmicort 518 (24) (24) 5 (21) 414 (27) (27) 63 (12) (15) 36 (1) 1 Airsupra 166 n/m n/m 162 n/m 4 n/m n/m - - - - - - Other R&I 274 (31) (32) 75 (55) 133 (21) (21) 59 2 - 7 (5) (2) R&I 8,167 10 10 3,840 12 1,823 (4) (3) 1,701 20 16 803 17 18 Beyfortus 281 (12) (12) 184 (21) - - - 94 12 12 3 58 53 Synagis 292 (35) (34) (3) (57) 214 2 4 50 (56) (57) 31 (76) (76) FluMist 272 6 3 28 1 5 n/m n/m 210 3 (1) 29 19 19 Other V&I 1 (96) (96) - n/m 1 (45) (48) - n/m n/m - n/m n/m V&I 846 (20) (20) 209 (26) 220 3 5 354 (13) (15) 63 (60) (60) Ultomiris 4,718 20 19 2,667 18 261 84 90 1,053 19 15 737 16 15 Soliris 1,837 (29) (28) 1,092 (28) 405 (9) (1) 200 (52) (53) 140 (32) (31) Strensiq 1,678 19 18 1,332 14 104 94 84 123 25 21 119 23 23 Koselugo 662 25 22 219 3 228 29 25 161 57 51 54 38 38 Other Rare Disease 231 11 10 113 14 40 16 18 67 1 (2) 11 23 23 Rare Disease 9,126 5 5 5,423 3 1,038 22 26 1,604 2 (1) 1,061 7 7 Nexium 816 (6) (5) 67 (30) 611 3 5 50 (18) (20) 88 (26) (26) Other 156 (24) (24) (4) n/m 121 (16) (15) 34 (21) (21) 5 18 17 Other Medicines 972 (9) (8) 63 (43) 732 - 1 84 (19) (20) 93 (25) (24) Total Medicines 55,573 9 9 23,444 8 15,056 11 13 12,021 11 7 5,052 3 3 The table provides an analysis of year-on-year Product Sales, with Actual and CER growth rates reflecting year-on-year growth. ===== SIDA 35 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 35 Table 29: Product Sales year-on-year analysis: Q4 2025 The Q4 2025 information in respect of the three months ended 31 December 2025 included in the Consolidated Financial Information has not been audited by PricewaterhouseCoopers LLP. For the quarter World US Emerging Markets Europe Established RoW ended 31 December Change Change Change Change Change $m Act % CER % $m Act % $m Act % CER % $m Act % CER % $m Act % CER % Tagrisso 1,902 12 10 841 10 462 18 17 393 14 6 206 2 4 Imfinzi 1,747 39 37 1,025 42 178 57 53 359 42 32 185 10 12 Calquence 967 20 17 637 11 69 86 73 215 29 20 46 48 50 Lynparza 878 4 1 380 - 182 1 (5) 247 12 4 69 4 6 Enhertu 292 97 95 - - 192 n/m n/m 62 78 64 38 76 78 Zoladex 254 5 4 6 17 181 4 4 45 21 15 22 (14) (12) Truqap 233 43 41 174 18 7 n/m n/m 40 n/m n/m 12 n/m n/m Imjudo 93 27 26 62 36 5 1 3 16 56 45 10 (19) (18) Datroway 1 n/m n/m - - 1 n/m n/m - - - - - - Other Oncology 103 (3) (3) 3 (14) 65 - - 4 (26) (31) 31 (4) (2) Oncology 6,470 21 19 3,128 18 1,342 27 25 1,381 28 19 619 10 12 Farxiga 2,059 7 2 486 3 701 12 8 794 9 1 78 (24) (22) Crestor 275 6 6 9 (33) 233 12 12 - n/m n/m 33 (4) (3) Brilinta 158 (54) (54) 67 (68) 71 15 13 18 (73) (75) 2 (62) (56) Lokelma 181 21 19 75 - 30 62 61 38 45 34 38 24 26 Seloken 139 (1) (1) - - 134 (2) (2) 4 37 48 1 48 n/m roxadustat 47 (37) (37) - - 47 (37) (37) - - - - - - Wainua 69 66 64 67 60 - n/m n/m 2 n/m n/m - - - Other CVRM 116 (39) (40) 5 (89) 54 (18) (18) 39 (30) (34) 18 (31) (30) CVRM 3,044 (3) (6) 709 (17) 1,270 6 4 895 1 (6) 170 (15) (13) Symbicort 704 3 2 289 (3) 177 16 15 154 7 1 84 (4) (2) Fasenra 530 12 10 309 3 36 56 51 131 19 11 54 38 41 Breztri 294 14 13 153 2 59 31 30 55 32 23 27 28 29 Tezspire 141 76 68 - - 16 n/m n/m 90 75 63 35 40 43 Saphnelo 203 38 37 175 33 6 n/m n/m 15 74 61 7 34 41 Pulmicort 161 (2) (6) 1 n/m 134 (5) (9) 17 (18) (25) 9 (12) (10) Airsupra 51 n/m n/m 49 98 2 n/m n/m - - - - - - Other R&I 63 (60) (60) 8 (92) 38 (4) (6) 15 - (3) 2 (4) (2) R&I 2,147 8 6 984 (1) 468 15 12 477 22 14 218 15 17 Beyfortus 59 (55) (56) 48 (44) - - - 11 (75) (75) - n/m n/m Synagis 72 (29) (31) (2) (72) 54 28 23 14 (61) (63) 6 (82) (81) FluMist 140 (6) (9) 8 n/m 4 n/m n/m 128 (11) (14) - n/m n/m Other V&I 1 n/m n/m - n/m 1 (51) (67) - n/m n/m - - - V&I 272 (28) (30) 54 (32) 59 32 26 153 (30) (33) 6 (82) (82) Ultomiris 1,265 16 15 705 12 84 71 70 284 21 13 192 11 13 Soliris 401 (26) (26) 247 (30) 79 1 5 41 (42) (46) 34 (20) (19) Strensiq 490 17 15 379 8 43 n/m n/m 34 34 25 34 25 28 Koselugo 163 (1) (4) 62 10 39 (43) (44) 46 58 46 16 44 46 Other Rare Disease 55 (9) (11) 31 10 3 (68) (66) 17 (12) (18) 4 52 55 Rare Disease 2,374 4 3 1,424 - 248 12 10 422 11 4 280 9 11 Nexium 190 (3) (4) 14 (27) 135 1 1 18 (7) (13) 23 (7) (6) Other 41 (21) (20) - n/m 33 (13) (12) 7 (16) (16) 1 (22) (6) Other Medicines 231 (7) (7) 14 (41) 168 (2) (1) 25 (10) (14) 24 (8) (6) Total Medicines 14,538 9 7 6,313 5 3,555 15 13 3,353 12 5 1,317 4 6 The table provides an analysis of year-on-year Product Sales, with Actual and CER growth rates reflecting year-on-year growth. ===== SIDA 36 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 36 Table 30: Alliance Revenue: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m Enhertu 1,798 1,437 Tezspire 673 436 Beyfortus 422 237 Datroway 77 - Other royalty income 92 91 Other Alliance Revenue 5 11 Total 3,067 2,212 Table 31: Collaboration Revenue: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m Farxiga: sales milestones 87 56 Lynparza: sales milestones - 600 Beyfortus: sales milestones - 167 Koselugo: sales milestone - 100 Other Collaboration Revenue 12 - Total 99 923 Table 32: Other operating income and expense: FY 2025 For the twelve months ended 31 December 2025 $m 2024 $m Total 381 252 ===== SIDA 37 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 37 Financial calendar Announcement of Q1 2026 results: 29 April 2026 Dividend payment dates Dividends are normally paid as follows: First interim: Announced with the half year results and paid in September Second interim: Announced with the full year results and paid in March Dividend dates Dividend Announced Ex-dividend date1: LSE, NASDAQ Stockholm Ex-dividend date1: NYSE Record date Payment date FY 2025 Second interim 10 Feb 2026 19 Feb 2026 20 Feb 2026 20 Feb 2026 23 Mar 2026 FY 2026 First interim2 27 Jul 2026 6 Aug 2026 7 Aug 2026 7 Aug 2026 8 Sep 2026 The completion of cross-border movements of shares by intermediaries between the London Stock Exchange, Nasdaq Stockholm and the New York Stock Exchange is subject to the receiving broker identifying and confirming such movements. Where a cross-border movement of shares is initiated but not completed by the relevant dividend record dates (being 20 February 2026 and, provisionally, 7 August 2026), the dividend in respect of those shares will be received in the originating market on the relevant dividend payment date. Accordingly, shareholders are advised not to initiate any cross-border movements of shares: (a) during the period from 18 February 2026 to 20 February 2026 (inclusive) in respect of the FY 2025 Second interim dividend; and (b) during the period from 5 August 2026 to 7 August 2026 (inclusive) in respect of the FY 2026 First interim dividend2. Contact details For Investor Relations contacts, click here. For Media contacts, click here. Addresses for correspondence Registered office UK Registrar and Transfer Office Swedish Central Securities Depository US Registrar and Transfer Agent 1 Francis Crick Avenue Cambridge Biomedical Campus Cambridge CB2 0AA Computershare Investor Services PLC The Pavilions Bridgwater Road Bristol BS99 6ZZ Euroclear Sweden AB PO Box 191 SE-101 23 Stockholm Computershare Investor Services PO Box 43078 Providence RI, 02940-3078 UK UK Sweden US +44 (0) 20 3749 5000 0800 707 1682 (UK only) +46 (0) 8 402 9000 +1 (888) 697 8018 (US only) +44 (0) 370 707 1682 +1 (781) 575 2844 Trademarks Trademarks of the AstraZeneca group of companies appear throughout this document in italics. Medical publications also appear throughout the document in italics. AstraZeneca, the AstraZeneca logotype and the AstraZeneca symbol are all trademarks of the AstraZeneca group of companies. Trademarks of companies other than AstraZeneca that appear in this document include: Beyfortus, a trademark of Sanofi Pasteur Inc.; Enhertu and Datroway, trademarks of Daiichi Sankyo; Seloken, owned by AstraZeneca or Taiyo Pharma Co., Ltd (depending on geography); Synagis, owned by AstraZeneca or Sobi aka Swedish Orphan Biovitrum AB (publ). (depending on geography); and Tezspire, a trademark of Amgen, Inc. Information on or accessible through AstraZeneca's websites, including astrazeneca.com, does not form part of and is not incorporated into this announcement. 1 The ex-dividend dates for the principal markets differ due to the different settlement cycles currently applicable in the UK for shares trading on the London Stock Exchange, Nasdaq Stockholm and the New York Stock Exchange. Shareholders should consider the applicable ex-dividend date for the securities they hold in each market. 2 Provisional dates, subject to Board approval. Other shareholder information ===== SIDA 38 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 38 AstraZeneca AstraZeneca (LSE/STO/NYSE: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca’s innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Social Media @AstraZeneca. Cautionary statements regarding forward-looking statements In order, among other things, to utilise the 'safe harbour' provisions of the US Private Securities Litigation Reform Act of 1995, AstraZeneca (hereafter 'the Group') provides the following cautionary statement: This document contains certain forward-looking statements with respect to the operations, performance and financial condition of the Group, including, among other things, statements about expected revenues, margins, earnings per share or other financial or other measures. Although the Group believes its expectations are based on reasonable assumptions, any forward-looking statements, by their very nature, involve risks and uncertainties and may be influenced by factors that could cause actual outcomes and results to be materially different from those predicted. The forward-looking statements reflect knowledge and information available at the date of preparation of this document and the Group undertakes no obligation to update these forward-looking statements. The Group identifies the forward-looking statements by using the words 'anticipates', 'believes', 'expects', 'intends' and similar expressions in such statements. Important factors that could cause actual results to differ materially from those contained in forward-looking statements, certain of which are beyond the Group's control, include, among other things: – the risk of failure or delay in delivery of pipeline or launch of new medicines; – the risk of failure to meet regulatory or ethical requirements for medicine development or approval; – the risk of failures or delays in the quality or execution of the Group's commercial strategies; – the risk of pricing, affordability, access and competitive pressures; – the risk of failure to maintain supply of compliant, quality medicines; – the risk of illegal trade in the Group's medicines; – the risk of reliance on third-party goods and services; – the risk of failure in information technology or cybersecurity; – the risk of failure of critical processes; – the risk of failure to collect and manage data and artificial intelligence in line with legal and regulatory requirements and strategic objectives; – the risk of failure to attract, develop, engage and retain a diverse, talented and capable workforce; – the risk of failure to meet our sustainability targets, regulatory requirements and stakeholder expectations with respect to the environment; – the risk of failure to meet regulatory and ethical expectations on commercial practices, including anti-bribery anti-corruption, anti- fraud and scientific exchanges; – the risk of the safety and efficacy of marketed medicines being questioned; – the risk of adverse outcome of litigation and/or governmental investigations; – intellectual property risks related to the Group's products; – the risk of failure to achieve strategic plans or meet targets or expectations; – the risk of geopolitical and/or macroeconomic volatility disrupting the operation of our global business; – the risk of failure in internal control, financial reporting or the occurrence of fraud; and – the risk of unexpected deterioration in the Group's financial position. ===== SIDA 39 ===== Summary Revenue Drivers R&D Progress Sustainability Financial Performance Financial Statements Glossary 39 1L, 2L, etc First line, second line, etc AHA American Heart Association aHUS Atypical haemolytic uraemic syndrome AI Aromatase inhibitors ALK Anaplastic lymphoma kinase gene ASH American Society for Hematology ATTRv / -CM / -PN Hereditary transthyretin-mediated amyloid / cardiomyopathy / polyneuropathy BLA Biologics License Application BSI British Standards Institution BTC Biliary tract cancer BTKi Bruton tyrosine kinase inhibitor CER Constant exchange rates CHMP Committee for Medicinal Products for Human Use (EU) CI Confidence interval CKD Chronic kidney disease CLL Chronic lymphocytic leukaemia CN China COPD Chronic obstructive pulmonary disease CRL Compete Response Letter ctDNA Circulating tumour DNA CTx Chemotherapy CVRM Cardiovascular, Renal and Metabolism dMMR DNA mismatch repair eBC Early breast cancer EBITDA Earnings before interest, tax, depreciation and amortisation EGFR / m Epidermal growth factor receptor gene / mutation EGPA Eosinophilic granulomatosis with polyangiitis EPS Earnings per share EU Europe (in financial tables) or European Union EVH Extravascular haemolysis EVP Executive Vice President FDA US Food and Drug Administration FDC Fixed dose combination FLOT Fluorouracil, oxaliplatin and docetaxel FY Full year / Financial year GAAP Generally Accepted Accounting Principles GEJ Gastro oesophageal junction GI Gastrointestinal GIPR Glucose-dependent insulinotropic polypeptide receptor agonist GLP1 / -R Glucagon-like peptide-1 / receptor agonist gMG Generalised myasthenia gravis HCC Hepatocellular carcinoma HER2 / +/- /low /m Human epidermal growth factor receptor 2 gene / positive / negative / low expression / gene mutant HF/ pEF / rEF Heart failure / with preserved ejection fraction / with reduced ejection fraction HPP Hypophosphatasia HR / + / - Hormone receptor / positive / negative IAS / B International Accounting Standards / Board ICS Inhaled corticosteroid IFRS International Financial Reporting Standards IHC Immunohistochemistry IL-5, IL-33, etc Interleukin-5, Interleukin-33, etc IO Immuno-oncology IP Intellectual Property ISH In situ hybridization JP Japan LABA Long-acting beta-agonist LAMA Long-acting muscarinic-agonist LSE London Stock Exchange mBC Metastatic breast cancer MCL Mantle cell lymphoma n/m Growth rate not meaningful NF1 Neurofibromatosis type 1 NHS National Health Service (UK) NMOSD Neuromyelitis optica spectrum disorder NRDL National reimbursement drug list NSCLC Non-small cell lung cancer NYSE New York Stock Exchange OS Overall survival PARP Poly ADP ribose polymerase PD Progressive disease pMMR proficient mismatch repair PNH Paroxysmal nocturnal haemoglobinuria PSA Prostate-specific antigen R&I Respiratory & Immunology SABCS San Antonio Breast Cancer Symposium SBP systolic blood pressure SC Subcutaneous SEA Severe eosinophilic asthma SEC Securities Exchange Commission (US) SG&A Sales, general and administration SGLT2 Sodium-glucose cotransporter 2 SLE Systemic lupus erythematosus SMI Sustainable Markets Initiative SPA Share Purchase Agreement TNBC Triple negative breast cancer VBP Volume-based procurement YTD Year to date V&I Vaccines & Immune Therapies Glossary