FULLTEXT DEL 1 AV 1
Kvartalsrapport Q3 2025
===== SIDA 1 ===== z z Q3 2025 Earnings Presentation 12 NOVEMBER 2025 ===== SIDA 2 ===== z Disclaimer 2 This presentation (“Presentation”) does not contain or constitute an offer to sell, a solicitation of an offer to buy, or a recommendation to purchase any security of Alvotech (the “Company”) to any person in the United States or in any jurisdiction to whom or in which such offer or solicitation is unlawful. Any trademarks, servicemarks, trade names and copyrights of the Company and other companies contained in this Presentation are the property of their respective owners. This Presentation is strictly confidential to the recipient, it is being distributed to a limited range of invited persons solely for their own information, may not be distributed to the press or any other person, and may not be reproduced or published, in whole or in part, in any form. Failure to comply with this restriction may constitute a violation of applicable securities laws. Forward-Looking Statements Certain statements in this communication may be considered “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements include, for example, Alvotech’s expectations regarding competitive advantages, business prospects and opportunities including pipeline product development, future plans and intentions, regulatory submissions, review and interactions, the potential approval and commercial launch of its product candidates, the timing of regulatory approval, market launches and financial projections. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Alvotech and its management, are inherently uncertain and are inherently subject to risks, variability, and contingencies, many of which are beyond Alvotech’s control. Factors that may cause actual results to differ materially from current expectations include, but are not limited to factors set forth in the sections entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements” in documents that Alvotech may from time-to-time file or furnish with the SEC. There may be additional risks that Alvotech does not presently know or that Alvotech currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, assurance, prediction or definitive statement of a fact or probability. Alvotech does not undertake any duty to update these forward-looking statements or to inform the recipient of any matters of which any of them becomes aware of which may affect any matter referred to in this communication. Alvotech disclaims any and all liability for any loss or damage (whether foreseeable or not) suffered or incurred by any person or entity as a result of anything contained or omitted from this communication and such liability is expressly disclaimed. Non-IFRS Financial Measures This Presentation may include projections of certain financial measures not presented in accordance with International Financial Reporting Standards (“IFRS”) including, but not limited to, Adjusted EBITDA and certain ratios and other metrics derived therefrom. These non-IFRS financial measures are not measures of financial performance in accordance with IFRS and may exclude items that are significant in understanding and assessing the Company’s financial results. Therefore, these measures should not be considered in isolation or as an alternative to net income, cash flows from operations or other measures of profitability, liquidity or performance under IFRS. You should be aware that the Company’s presentation of these measures may not be comparable to similarly-titled measures used by other companies. The Company believes these non-IFRS measures of financial results provide useful information to management and investors regarding certain financial and business trends relating to the Company’s financial condition and results of operations. The Company believes that the use of these non-IFRS financial measures provide an additional tool for investors to use in evaluating ongoing operating results and trends and in comparing the Company’s financial measures with other similar companies, many of which present similar non-IFRS financial measures to investors. These non-IFRS financial measures are subject to inherent limitations as they reflect the exercise of judgments by management about which expense and income are excluded or included in determining these non- IFRS financial measures. Due to the high variability and difficulty in making accurate forecasts and projections of some of the information excluded from these projected measures, together with some of the excluded information not being ascertainable or accessible, the Company is unable to quantify certain amounts that would be required to be included in the most directly comparable IFRS financial measures without unreasonable effort. Consequently, no disclosure of estimated comparable IFRS measures is included and no reconciliation of the forward-looking non- IFRS financial measures is included. For the same reasons, the Company is unable to address the probable significance of the unavailable information, which could be material to future results. ===== SIDA 3 ===== zzz Róbert Wessman CHAIRMAN AND CHIEF EXECUTIVE OFFICER z z ===== SIDA 4 ===== z Alvotech is a leading pure play biotech company © Alvotech. All rights reserved 4 INVESTED IN THE PLATFORM AND PORTFOLIO ~$2bn 1 Launches reflect a specific molecule into a single market; 2 Expected approvals reflect approval in a major market (US or Europe) BIOSIMILAR LAUNCHES1 >60 (across both AVT02 and AVT04) COMMERCIAL PARTNERSHIPS 19 >$185bn TOTAL ADDRESSABLE MARKET APPROVED BIOSIMILARS 5 OUR VISION ”Our vision is to build a leading global biosimilar company, focused on improving the quality of life for patients around the world” Vertically Integrated Infrastructure Multi- Product Portfolio Global Reach Strategy Pure Play Biosimilar Platform +420% REVENUE GROWTH 2024 ===== SIDA 5 ===== z 5© Alvotech. All rights reserved Update on FDA process and pipeline Revised outlook for FY25Key Topics → FDA issuance of a CRL for AVT05 only cited unresolved issues identified during inspection in July → Reykjavik manufacturing facility remains approved for commercialized products, i.e. bHumira and bStelara → Approvals and/or positive CHMP opinions already received for AVT06, AVT05, and AVT03 by EMA and Japan’s PMDA → As announced previously, outlook was revised for revenues at $570m- $600m and Adj. EBITDA at $130m-$150m, with strong licencing revenues expected in 4Q25 to support margin expansion → Impact on product revenues and operating expenses expected to continue into 4Q25 FDA: U.S. Food and Drug Administration; CRL: Complete Response Letter; EMA: European Medicines Agency; CHMP: Committee for Me dicinal Products for Human Use; AVT03: biosimilar to Prolia®/Xgeva®; AVT05: biosimilar to Simponi®/Simponi Aria®; AVT06: biosimilar to Eylea® Update on marketed products → Holding market share in Humira U.S. market as share of originator continues to fall and growing share of E.U. Humira market → Continue adding formulary coverage for bStelara in U.S. and holding a leading position for bStelara in Europe ===== SIDA 6 ===== z Approval of AVT05 BLA delayed by CRL, but facility remains approved 6© Alvotech. All rights reserved FDA’s complete response letter for AVT05 → FDA issued a CRL for AVT05 in PFS and AI presentations, only citing unresolved issues identified during inspection in July → The FDA did not identify any other deficiencies with this BLA → Alvotech submitted a comprehensive response to the FDA detailing its Corrective and Preventive Action (CAPA) plan in July 2025 U.S. Food and Drug Administration (FDA) issued a Complete Response Letter (CRL) for Alvotech’s biosimilar candidate to Simponi® (golimumab) in prefilled syringe (PFS) and autoinjector (AI). Manufacturing facility remains approved for on-market products. → Reykjavik manufacturing facility remains FDA approved for commercialized products → Production continues for on-market products, bHumira (AVT02) and bStelara (AVT04) for all approved markets, including the U.S. → Approvals and/or positive opinions already received from Japan and EU for bEylea (AVT06), bSimponi (AVT05), and bEyela/bXgeva (AVT03); UK approvals for bSimponi (AVT05) and bEylea (AVT06) → Once the FDA provides clarity later this month on the specific issues identified during the inspection, Alvotech will address them in a timely manner → Statutory review time for a CRL response is 6 months → Alvotech expects to be first to launch a bSimponi in EU, UK, and Japan → Alvotech anticipates being one of the first, if not the only, approved biosimilar to Simponi in the US and other global markets Reykjavik facility remains FDA approved Next steps for FDA approval of AVT05 ===== SIDA 7 ===== z Robust revenue growth YoY › Revised outlook for FY2025 for topline revenues to $570-600m (vs $600-700m prior) and EBITDA revised to $130-150m (vs $200- 280m prior) › Product Revenues have been gaining momentum since launch of first biosimilar AVT02 in 2022 › Significant step-up in product revenues in 2024 following first market launch of bHumira, Simlandi (AVT02) in the US, as well as the market launch of the Company’s second biosimilar bStelara, Selarsdi, (AVT04) in early 2025 › Three new biosimilars coming to market in coming months – AVT03, AVT05 and AVT06 - approvals and positive opinions already received from the UK, the EU Committee for Medicinal Products for Human Use (CHMP), and Japan’s PMDA › Licensing Revenues expected to continue as a significant revenue contributor and deliver $250-300m annually until 2030 driven by strong development pipeline and contributions from new launches © Alvotech. All rights reserved 7 Proven record of strong sales potential for on-market products and solid performance-based licencing revenues Total revenues for full-year 2025 expected in the range of $570-600 million USD m 42 60 49 219 189 25 45 273 231 FY21 FY22 FY23 FY24 9M25 2025F 85 94 492 420 570-600 Product revenues Licensing & other revenues Notes: 1 CAGR calculations for 2021-2025 assume an estimated revenue mid -point of $585m. ===== SIDA 8 ===== z 8© Alvotech. All rights reserved AVT02 Biosimilar to Humira® (adalimumab) AVT04 Biosimilar to Stelara® (ustekinumab) Continued momentum of on-market products → Alvotech’s biosimilar to Humira continues holding 2nd largest market share of Humira biosimilars in the U.S. → U.S. market share of originator falling and reaching 50% of original volume at year end with most patients transitioning to biosimilars → European volumes of our Humira biosimilar in Europe continue growing → Hukyndra holds top position in several of EU10 markets and experienced 12% QoQ growth for last four consecutive quarters → Seeing positive impact of our steadfast strategy to grow U.S. business for our Stelara biosimilar → Partner Teva has continued to secure formulary coverage for our Stelara biosimilar → In Europe, in leading position across markets where launched with overall share of total Stelara market around 10% → Expect 50% of Stelara market in Europe to transition to biosimilars by year end IMMUNOLOGY Filing Approval Launch 72 markets 68 markets 34 markets Filing Approval Launch 70 markets 51 markets 30 markets IMMUNOLOGY ===== SIDA 9 ===== zzz Joseph McClellan CHIEF OPERATING OFFICER z z ===== SIDA 10 ===== z 10© Alvotech. All rights reserved AVT05 referencing Simponi® Upcoming product launches in Europe on track → Already approved in Japan, UK and European Economic Area → Regeneron’s injunction request rejected by UK High Court → Market growth in Europe has been steady at single digits YoY → Expect to be in first wave of entrants in Europe with strong partners → Have received orders for 10% of overall Eylea market in Europe from partners Total addressable market (TAM)[1]: Global $10.2 / ex-US $3.9 bn → Already approved in Japan and UK, EMA’s CHMP recommends EEA approval → Launch in Japan expected in first half of 2026 and expected in Europe in Q425 → Expect to be first to launch Simponi biosimilar in Japan and Europe → Expect to be only Simponi biosimilar for some months after launch Filing Approval Launch 38 markets 2 markets 0 markets Total addressable market (TAM) [2]: Global $3.5 bn / ex-US $2.4 bn AVT06 Referencing Eylea® OPHTHALMOLOGY Filing Approval Launch 38 markets 36 markets 0 markets IMMUNOLOGY AVT03 referencing Prolia®/ Xgeva® → Approved in Japan, CHMP recommended EEA approval → Launch in Japan expected in H126 and in Europe in Q425 → YoY market growth in Europe mid/high single digits → Expect to be in first wave of European launches with strong partners STADA and Dr. Reddy’s Laboratories Total addressable market (TAM): Global $7bn / ex-US $2.6 bn Filing Approval Launch 38 markets 1 markets 0 markets BONE DISEASE [1] TAM refers to global and ex-US peak annual sales of the originator. Source: Globaldata. [2] US sales include combined sales of Simponi and Simponi Aria. Simponi Aria is only approved in the US. Source: Globaldata. ===== SIDA 11 ===== z BIOSIMILAR CANDIDATE REFERENCE BIOLOGIC THERAPEUTIC AREA EARLY PHASE PRE-CLINICAL CLINICAL STUDIES FILING APPROVAL AVT03 denosumab PROLIA®/ XGEVA® Bone Disease AVT05 golimumab SIMPONI®/ SIMPONI ARIA® Immunology AVT06 aflibercept EYLEA® Ophthalmology AVT231 omalizumab XOLAIR® Respiratory AVT16/802 vedolizumab ENTYVIO® Immunology AVT29 aflibercept EYLEA® HD Ophthalmology AVT323 pembrolizumab KEYTRUDA® Oncology AVT10 certolizumab pegol CIMZIA® Immunology AVT28 ixekizumab TALTZ® Immunology AVT48 canakinumab ILARIS® Immunology AVT41 guselkumab TREMFYA® Immunology AVT65 ofatumumab KESIMPTA® Immunology AVT19 dupilumab DUPIXENT® Immunology AVT87 emicizumab HEMLIBRA® Hematology AVT34 durvalumab IMFINIZI® Oncology Continued advancement in development pipeline 11 1AVT23 rights licensed from Kashiv BioSciences for EU, UK, Australia, Canada, and New Zealand, 2Represents vial and PFS presentations of Entyvio, respectively, 3AVT32 is co-developed with Dr Reddy’s SIMPONI, SIMPONI ARIA and TREMFYA are registered trademarks of Johnson & Johnson Inc.; XOLAIR, ILARIS and KESIMPTA are a registered trademarks of Novartis AG; PROLIA AND XGEVA are registered trademarks of Amgen, Inc.; EYLEA is a registered trademark of Regeneron Pharmaceuticals, Inc.; ENTYVIO is a registered trademark of Millennium Pharmaceuticals, Inc.; KEYTRUDA is a registered trademark of Merck Sharp & Dohme Corp; CIMZIA is a registered trademark of UCB Pharma S.A.; DUPIXENT is a trademark and brand of Sanofi Biotechnology; TALTZ is a registered trademark of Eli Lilly and Company; HEMLIBRA is a registered trademark of Chugai Pharmaceutical Co.; IMFINZI is a registered trademark of the AstraZeneca group of companies Launching in 2025 Late-stage development Early-stage development 37 MARKETS 37 MARKETS 38 MARKETS 31 MARKETS 36 MARKETS 1 MARKET 2 MARKETS In addition to these named programs, Alvotech has created over 15 cell lines for further development 38 MARKETS 38 MARKETS 38 MARKETS ===== SIDA 12 ===== zzz Linda Jónsdottir CHIEF FINANCIAL OFFICER zz ===== SIDA 13 ===== z Executive summary 3Q25 → 3Q25 in line with expectations → Product revenues and product margin impacted by timing of orders, portfolio mix and investments in facility improvements → Continued momentum in demand appetite for on-market products of bHumira and bStelara, albeit more competitive pricing environment → Licencing revenues driving strong gross margin of 69% because of revenue mix → Total revenues include revenues of $7m and EBITDA of $1m from bolt-on acquisition of Ivers Lee in July 2025 → Adj.EBITDA at $14m, representing a 13% margin, impacted by costs associated with improvements in operations to support new launches → Operating cash flow impacted by lower revenue collection in the quarter and high inventory level related to build up for upcoming launches © Alvotech. All rights reserved 13 Q3 2025 Financial highlights Total revenues USD m Gross margin % of revenues Product margin % of revenues Adj. EBITDA USD m Adj. EBITDA margin % of revenues Operating cash flow USD m 62 47 51 58 69 3Q24 4Q24 1Q25 2Q25 3Q25 -61 -39 17 59 -41 3Q24 4Q24 1Q25 2Q25 3Q25 23 22 21 33 14 3Q24 4Q24 1Q25 2Q25 3Q25 -37% 22 14 15 19 13 3Q24 4Q24 1Q25 2Q25 3Q25 37 45 41 23 -7 3Q24 4Q24 1Q25 2Q25 3Q25 103 153 133 173 114 3Q24 4Q24 1Q25 2Q25 3Q25 +11% ===== SIDA 14 ===== z Executive summary 9M25 © Alvotech. All rights reserved 14 9M 2025 Financial highlights Total revenues USD m Gross margin % of revenues Product margin % of revenues Adj. EBITDA USD m Adj. EBITDA margin % of revenues Cash balance USD m 85 93 492 339 420 FY22 FY23 FY24 9M24 9M25 +24% -145 -220 33 19 27 FY22 FY23 FY24 9M24 9M25 +42% -205 -291 108 87 68 FY22 FY23 FY24 9M24 9M25 28 -67 63 69 59 FY22 FY23 FY24 9M24 9M25 66 11 51 118 43 FY22 FY23 FY24 9M24 9M25 → Total revenues at $420m in 9M25, YoY revenue growth 24% compared to same period 2024 → Revenue growth reflects the continued commercial momentum after U.S. launch of bHumira (AVT02) and early traction for bStelara (AVT04) in 2025 → Gross margin at 59% underscores the strength of our licensing model → Product margin at 27% reflects softness in 3Q25 → Adj. EBITDA of $68m, or 16% margin, impacted by softness in 3Q25, margin was comparatively higher in 9M24 due to higher licensing revenues following FDA facility and product approvals → Cash balance was $43m at end of September 2025, reflects inventory build-up ahead of upcoming product launches, CAPEX and bolt-on acquisition of Ivers-Lee and asset purchase from Xbrane -241 -312 22 26 16 FY22 FY23 FY24 9M24 9M25 ===== SIDA 15 ===== z Revenues1 by geography % Revenues and Adj.EBITDA margin → In 3Q25, total revenues at $114m, up 11% YoY , with a run-rate of $571m in the last twelve months (LTM) → Product revenues lower in the quarter at $33m, down by 47% YoY due to product mix and timing of orders → Product revenues expected to pick up in 4Q25 with 3 upcoming product launches → Licensing Revenues a significant revenue contributor at $81m in 3Q25, up 98% YoY and 4% QoQ → In 9M25, total revenues were at $420m, up 24% YoY → Product revenues at $237m, up 85% YoY and accounting for 56% of total revenues in 9M25 → Licensing revenues at $183m, down 13% YoY in line with expectations, accounting for 44% of total revenues → Continued geographical diversification of revenues as market share builds across in Europe and other regions outside of U.S. © Alvotech. All rights reserved 15 Revenue run rate of $571m in last twelve months and continued geographical diversification of revenues Notes: 1 Revenues reflect product & service revenues and licensing and other revenue, other income not included in total revenues. Revenues1 and adj. EBITDA margin USD m, % of revenues 62 145 110 95 33 41 78 81 0 5 10 15 20 25 0 50 100 150 200 22% 3Q24 14% 6 4Q24 15% 23 1Q25 19% 2Q25 13% 3Q25 103 151 133 173 114 Adj.EBITDA margin Product & service revenues Licensing & other revenues 12% 18% 32% 37% 50% 56% 46% 44% FY24 9M24 6% 9M25 US Europe ROW 128 237 210 183 0 5 10 15 20 25 30 0 100 200 300 400 500 26% 9M24 16% 9M25 338 420 ===== SIDA 16 ===== z Cash flow Cash flow → Operating cash flow at -$41m impacted by lower revenue collection in the quarter and inventory build-up for new product launches → Cash balance at period end 30 Sep 2025 at $43m, lower than end of June, driven by inventory build-up for new launches, CAPEX and bolt-on acquisitions. → New working capital option of $100m will be used for working capital needs → CAPEX and intangibles at $28m in the quarter in support of capacity expansion and future product launches → Acquisitions related to Ivers Lee net payment of $14m less collected $3m due to sale of joint venture in 2024 → Net interest payments at $14m, transitioning from PIK to cash interest from June 2025 © Alvotech. All rights reserved 16 Cash flow impacted by timing of collections and inventory build-up for upcoming launches Cash flow bridge Q3 2025 USD m -61 -39 17 59 -41 3Q24 4Q24 1Q25 2Q25 3Q25 118 51 39 151 43 9M24 12M24 3M25 6M25 9M25 Operating cash flow USD m Cash balance USD m 151 43 18 53 14 28 Cash 30 June 2025 Operating cash before working capital Inventories 6 Other working capital & operating items Net interest payments CAPEX and intangiables 11 Acquisitions 13 Net borrowings Cash 30 Sep 2025 ===== SIDA 17 ===== z Balance sheet: Assets Assets → Strong asset base supported by strategic acquisitions and pipeline investments → Non-current assets up $211m driven by Ivers-Lee acquisition (PPA), Xbrane AVT10 acquisition, and higher contract assets due to timing of revenue recognition and upfront payments → Total current assets stable with shifts in inventory and trade receivables during the period. Inventory increased by $80m to build up for upcoming launches and trade receivables decreased by $102m due to high collections. © Alvotech. All rights reserved 17 Unaudited condensed consolidated interim financial statements as of 30 September 2025 Assets (USD thousands) September 2025 December 2024 Change % Non-current assets Property, plant and equipment 352,471 284,546 24% Right-of-use assets 141,709 125,198 13% Goodwill 12,803 11,330 13% Other intangible assets 61,869 20,621 200% Contract assets 58,696 22,710 158% Other long-term financial assets 4,394 — Other long-term assets 4,727 3,615 31% Deferred tax assets 340,503 298,360 14% Total non-current assets 977,172 766,380 28% Current assets Inventories 207,729 127,889 62% Trade receivables 58,308 160,217 -64% Contract assets 63,043 67,304 -6% Other current assets 59,078 48,064 23% Receivables from related parties 1,000 118 747% Cash and cash equivalents 42,848 51,428 -17% Total current assets 432,006 455,020 -5% Total assets 1,409,178 1,221,400 15% ===== SIDA 18 ===== z Balance sheet: Equity & liabilities Equity and liabilities → Equity position strengthened by $236m mainly driven by profit for the period and capital contributions through Swedish listing → Derivative financial liabilities reduced by $167m mainly due to fair value changes on earnout shares → Increase in borrowings mainly related to PIK interest in 1H25 on senior term loan and absorbed Ivers-Lee borrowings → Overall contract liabilities decreasing due to recognition of licencing revenues © Alvotech. All rights reserved 18 Unaudited condensed consolidated interim financial statements as of 30 September 2025 Equity and Liabilities (USD thousands) September 2025 December 2024 Change % Total equity (176,763) (412,771) 57% Non-current liabilities Borrowings 1,081,626 1,035,882 4% Derivative financial liabilities 42,702 210,224 -80% Lease liabilities 144,516 112,137 29% Contract liabilities 5,489 80,721 -93% Deferred tax liability 7,539 1,811 316% Total non-current liabilities 1,281,872 1,440,775 -11% Current liabilities Trade and other payables 91,628 67,126 37% Lease liabilities 13,297 9,515 40% Current maturities of borrowings 42,722 32,702 31% Liabilities to related parties 4,353 8,465 -49% Contract liabilities 49,923 15,980 212% Taxes payable 1,769 204 767% Other current liabilities 100,377 59,404 69% Total current liabilities 304,069 193,396 57% Total liabilities 1,585,941 1,634,171 -3% Total equity and liabilities 1,409,178 1,221,400 15% ===== SIDA 19 ===== z Total revenues 9M25 and outlook FY25 USD m Revised outlook 2025 Revised outlook announced on 4 November › Impact from investments in facility improvements expected to continue into 4Q25 › Licensing agreements for pipeline assets shifting to 2026 › Based on the committed orders for new launches in markets outside the U.S., combined with the growth momentum noted in currently marketed products, Alvotech is well positioned to deliver top-line and EBITDA growth in 2026 › Management will provide new future outlook no later than with the FY2025 results Strategic focus in next 18 months › Leverage platform investments to support pipeline progression and new product launches › Deliver solid sales growth and diversification of revenue base by product and geography › Drive cost optimization and operational efficiencies to support margin expansion › Continued discipline in working capital management to achieve positive free cash flow © Alvotech. All rights reserved 19 Revised outlook for full-year 2025 announced for revenues and EBITDA on 4 November Financial outlook for full-year 2025 Adj. EBITDA 9M25 and outlook FY25 USD m As stated in 4Q24 results As stated in 1Q25 results Revised outlook 4 Nov 2025 Revenues $ 570-670m $ 600-700m $ 570-600m Adj. EBITDA $ 180-260m $ 200-280m $ 130-150m 103 202 492 FY22 FY23 FY24 2025F 570-600 +96% +144% +19%1 -205 -291 108 FY22 FY23 FY24 2025F 130-150 +137% +30%2 Notes: 1 Revenue growth for 2025F assume an estimated revenue mid -point of $585m and 2 EBITDA growth assumes the estimated mid-point. ===== SIDA 20 ===== z 20© Alvotech. All rights reserved Successful execution from foundation in 2013 to a diversified revenue growth model based on a valuable pipeline portfolio Foundation for growth Diversification and scale → Investing in R&D and building up a vertically integrated manufacturing platform → Establishing high-value portfolio PipelineCommercialFinancials → Building global partnerships for commercial success → Initial market approvals for bHumira® and bStelara® → Approvals of five biosimilars in major markets → Accelerated the pace of our pipeline by advancing four to six process development projects annually → Access to US market established → Multiple global on-market launches → Launch ready in Europe for AVT03, AVT05, and AVT06 → Total revenues up 5x from 2023 to 2024 → Achieved positive EBITDA in 2024 → Bolt-on additions of Ivers-Lee in Switzerland and Xbrane in Sweden → Stock listing on Nasdaq Stockholm → Robust R&D efforts and FDA compliance → Leverage investments in the platform to support pipeline and future product launches → Multiple global product launches in approved markets outside of US and US after FDA approval → Total addressable market for launching biosimilars ~$20 bn1 → Drive operational efficiencies across the company → Working capital optimization → Lowering cost base and improving cost discipline → Optimising COGS → Stock listing in US and Iceland Commercial inflection point → Continued pipeline progression → Continued expansion of pipeline targets and strategic mapping of opportunities → Multiple global product launches → Expanding existing commercial partnerships for local access → A stable revenue model with diversified portfolio of on- market products → Leverage the integrated platform and optimize production 2027 -2030 Further revenue growth 2013-2023 2024 -2025 2026 1Based on peak annual sale of the originator. Source: Globaldata. ===== SIDA 21 ===== z Additional information and contacts © Alvotech. All rights reserved 21 We want to hear from you! Financial calendar and upcoming events Follow us and join the conversation investors.alvotech.com alvotech.com alvotech.ir@alvotech.com alvotech.ir@alvotech.com World outline World outline Envelope outline Balaji Prasad Chief Strategy Officer balajip@alvotech.com Patrik Ling VP of IR Scandinavia patrikl@alvotech.com Benedikt Stefansson VP of IR and Communications alvotech.ir@alvotech.com US SE IS SEB Healthcare Conference Stockholm, November 14, 2025 Jefferies Healthcare Conference, London, November 18, 2025 DNB Health Care Conference, Oslo, November 25, 2025 Citi Conference, Miami, December 2, 2025 Evercore Healthcare Conference Miami, December 3, 2025 ===== SIDA 22 ===== z Appendix ===== SIDA 23 ===== z 9M 2025 Adjustment Entries Cost of Product Revenue − $1.4m charge related to long-term incentive plan (non-cash) R&D − $1.2m charge related to long-term incentive plan (non-cash) − ($8.8m) IP litigation costs attributable to programs - reclassified from G&A G&A − $3.5m charge related to long-term incentive plan (non-cash) − $8.8m IP litigation costs attributable to programs - reclassified to R&D − $4.5m one-time transaction cost Effects from business comb. − ($8.0m) resulting from the acquisition of Ivers-Lee (non-cash) Finance Income − ($167.5m) fair value adjustment on derivatives (non-cash) Gain (Loss) on exting. of fin liab. − ($17.7m) gain resulting from refinancing of Senior Secured First Lien Term Loan Facility (non-cash) Exchange Rate Differences − $21.2m impact of exchange rate fluctuations (non-cash) Income Tax − ($5.7m) tax impact of discrete adj. in jurisdictions where tax benefits are available 9M 2024 Adjustment Entries Cost of Product Revenue − $1.2m charge related to long-term incentive plan (non-cash) R&D − $1.9m charge related to long-term incentive plan (non-cash) − ($1.3m) IP litigation costs attributable to programs - reclassified from G&A − ($1.1m) partial reversal of one-time AR reserve pertaining to the termination of AVT23 licensing agreement with Biosana (non-cash) G&A − $4.8m charge related to long-term incentive plan (non-cash) − $1.3m IP litigation costs attributable to programs - reclassified to R&D − $0.5m one-time transaction cost Impairment loss on inv. in JV − $3.0m from sales of China JV Finance Income − ($75.5m) fair value adjustment on derivatives (non-cash) Finance Costs − $117.5m fair value adjustment on derivatives (non-cash) Gain (Loss) on exting.of fin.liab. − $69.4m loss on remeasurement of bonds (non-cash) Exchange Rate Differences − ($1.7m) impact of exchange rate fluctuations (non-cash) Income Tax − ($1.0m) tax impact of discrete adj. in jurisdictions where tax benefits are available 23 Reported to Adjusted Reconciliation 9M 2025 9M 2024 $ millions Reported Adjustment Entries Adjusted Reported Adjustment Entries Adjusted Product and Service Revenue 237.4 - 237.4 128.0 - 128.0 License and Other Revenue 182.4 0.3 182.6 210.5 0.2 210.6 Other Income 0.3 (0.3) - 0.2 (0.2) - Cost of Product and Service Rev. (174.3) 1.4 (172.9) (105.0) 1.2 (103.8) R&D (144.5) (7.6) (152.1) (131.1) (0.5) (131.6) G&A (71.3) 16.8 (54.5) (46.4) 6.6 (39.9) Operating Profit 30.0 10.7 40.6 56.2 7.3 63.5 Effects from business combination 8.0 (8.0) - - - - Loss on sale of interest in JV - - - (3.0) 3.0 - Finance Income 170.7 (167.5) 3.2 79.1 (75.5) 3.6 Finance Costs (108.4) - (108.4) (237.7) 117.5 (120.2) Gain (Loss) on exting. of fin. liab. 17.7 (17.7) - (69.4) 69.4 - Exchange Rate Diffrences (21.2) 21.2 - 1.7 (1.7) - Profit (Loss) Before Taxes 96.6 (161.3) (64.7) (173.1) 119.9 (53.2) Income Tax Benefit 39.8 (5.7) 34.1 8.2 (1.0) 7.2 Profit (Loss) For The Period 136.5 (167.0) (30.6) (164.9) 118.9 (46.0) Basic Profit (Loss) Per Share (in $) 0.47 (0.11) (0.63) (0.18) Diluted Profit (Loss) Per Share (in $) 0.47 (0.11) (0.63) (0.18) EBITDA: Operating Profit (Loss) 30.0 10.7 40.6 56.2 7.3 63.5 D&A 27.4 - 27.4 23.1 - 23.1 EBITDA 57.4 10.7 68.1 79.3 7.3 86.6