FULLTEXT DEL 1 AV 3
10-Q – 2025-10-30 – biib-20250930.htm
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2025-09-30 0000875045 us-gaap:ServiceOtherMember biib:ReportableSegmentMember 2024-01-01 2024-09-30 0000875045 biib:VanquaBioInc.Member us-gaap:SubsequentEventMember 2025-10-01 2025-10-31 0000875045 us-gaap:LicenseMember us-gaap:SubsequentEventMember 2025-10-01 2025-10-31 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 0-19311 BIOGEN INC. (Exact name of registrant as specified in its charter) Delaware 33-0112644 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification No.) 225 Binney Street , Cambridge , MA 02142 ( 617 ) 679-2000 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) Securities registered pursuant to Section 12(b) of the Act: Title of each class Trading Symbol(s) Name of each exchange on which registered Common Stock, $0.0005 par value BIIB The Nasdaq Global Select Market Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days: Yes x No o Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files): Yes x No o Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and "emerging growth company" in Rule 12b-2 of the Exchange Act: Large accelerated filer x Accelerated filer ☐ Non-accelerated filer ☐ Smaller reporting company ☐ Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No x The number of shares of the issuer’s Common Stock, $0.0005 par value, outstanding as of October 28, 2025, was 146,702,272 shares. Table of Contents BIOGEN INC. FORM 10-Q — Quarterly Report For the Quarterly Period Ended September 30, 2025 TABLE OF CONTENTS Page PART I — FINANCIAL INFORMATION Item 1. Financial Statements (unaudited) Condensed Consolidated Statements of Income — For the Three and Nine Months Ended September 30, 2025 and 2024 8 Condensed Consolidated Statements of Comprehensive Income — For the Three and Nine Months Ended September 30, 2025 and 2024 9 Condensed Consolidated Balance Sheets — As of September 30, 2025 and December 31, 2024 10 Condensed Consolidated Statements of Cash Flow — For the Nine Months Ended September 30, 2025 and 2024 11 Condensed Consolidated Statements of Equity — For the Three and Nine Months Ended September 30, 2025 and 2024 12 Notes to Condensed Consolidated Financial Statements 14 Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations 54 Item 3. Quantitative and Qualitative Disclosures About Market Risk 84 Item 4. Controls and Procedures 86 PART II — OTHER INFORMATION Item 1. Legal Proceedings 87 Item 1A. Risk Factors 87 Item 2. Unregistered Sales of Equity Securities and Use of Proceeds 103 Item 5. Other Information 103 Item 6. Exhibits 104 Signatures 105 2 Table of Contents NOTE REGARDING FORWARD-LOOKING STATEMENTS This report contains forward-looking statements that are being made pursuant to the provisions of the Private Securities Litigation Reform Act of 1995 (the PSLRA) with the intention of obtaining the benefits of the “Safe Harbor” provisions of the PSLRA. These forward-looking statements may be accompanied by such words as “aim,” “anticipate,” "assume," “believe,” “contemplate,” “continue," "could," “estimate,” “expect,” “forecast,” “goal,” “guidance,” “hope,” “intend,” “may,” “objective,” "outlook," “plan,” “possible,” "potential," “predict,” “project,” “should,” “target,” “will,” “would” or the negative of these words or other words and terms of similar meaning. Given their forward-looking nature, these statements involve substantial risks and uncertainties and may be based on inaccurate assumptions. This report includes, among others, forward-looking statements regarding: • our expected financial and operating performance; • our long-term strategy and supporting business plans, including our product pipeline; • our expectations about continued growth through acquisitions and key collaborative relationships and funding arrangements; • our belief that our long-term competitive position depends upon our success in discovering and developing innovative, cost-effective products that serve unmet medical needs, along with our ability to manufacture products efficiently and to launch and market them effectively in a highly competitive environment; • our ability to obtain and maintain adequate coverage, pricing and reimbursement from third-party payors; • our expectations regarding certain legal and regulatory proceedings and investigations; and • our belief that our existing funds, when combined with cash generated from operations and our access to additional financing resources, if needed, are sufficient to satisfy our operating, working capital, strategic alliance, milestone payment, capital expenditure and debt service requirements for the foreseeable future. These forward-looking statements are based on management's current beliefs and assumptions and on information currently available to management. Given their nature, we cannot assure that any outcome expressed in these forward-looking statements will be realized in whole or in part. We caution that these statements are subject to risks and uncertainties, many of which are outside of our control and could cause future events or results to be materially different from those stated or implied in this document, including, among others, factors relating to: • our substantial dependence on the anticipated amount, timing and accounting of revenue from our products, including from the successful development of new products and approval of additional indications for our existing products, including but not limited to LEQEMBI and SKYCLARYS; • the anticipated amount, timing and accounting of contingent, milestone, royalty and other payments under licensing, collaboration, acquisition or divestiture agreements; tax positions and contingencies; collectability of receivables; pre-approval inventory; cost of sales; research and development costs; compensation and other selling, general and administrative expense; amortization of intangible assets; foreign currency exchange risk; estimated fair value of assets and liabilities; and impairment assessments, including for goodwill balances; • expectations, plans, prospects and the timing of actions relating to product approvals, approvals of additional indications for our existing products, sales, pricing, growth, reimbursement and launch of our marketed and pipeline products all of which is subject to governmental and regulatory oversight, and therefore subject to risks and uncertainties, including but not limited to those related to approvals, unfavorable or delayed reimbursements and coverage determinations, and changes in reimbursement policies or practices of payors and other third parties; • the potential impact of increased product competition in the biopharmaceutical and healthcare industry, as well as any other markets in which we compete, including increased competition from new originator therapies, generics, prodrugs and biosimilars of existing products and products approved under abbreviated regulatory pathways, including generic, prodrugs or biosimilar versions of our marketed products or competing products, including but not limited to, increased competition from TECFIDERA generic entrants in the U.S. and international markets and a biosimilar entrant of TYSABRI; • patent terms, patent term extensions, patent office actions and expected availability and periods of regulatory exclusivities, as well as our ability to adequately enforce existing patents, including our European patent related to TECFIDERA; 3 Table of Contents • our ability to effectively implement our corporate strategy which includes significant investment in product and pipeline candidates, including but not limited to felzartamab, litifilimab and nusinersen; • the successful execution of our strategic and growth initiatives, including acquisitions, and our ability to realize the anticipated benefits from our acquisitions of Reata and HI-Bio and the potential acquisition of Alcyone, including future performance of the SKYCLARYS product, further development of the felzartamab product, future development of drug delivery solutions and anticipated synergies; • the drivers for growing our business, including our plans and intention to commit resources relating to discovery, research and development programs and business development opportunities, including collaboration agreements, as well as the potential benefits and results of, and the anticipated completion of, certain business development transactions, reorganizations and cost-reduction measures, including our Fit for Growth program; • the expectations, development plans and anticipated timelines, including costs and timing of potential clinical trials, regulatory filing approvals and/or discontinuation, of our products, drug candidates and pipeline programs, including collaborations with third parties including but not limited to Eisai and Supernus, as well as the potential therapeutic scope of the development and commercialization of our and our collaborators’ pipeline products; • the impacts of disruptions, turnover or changes in strategy, priorities or capabilities at our collaborators resulting from, for example, a change in control, and the related impacts on the commercialization or manufacturing of our shared products; • the timing, outcome and impact of administrative, regulatory, legal and other proceedings, including those related to our patents and other proprietary and intellectual property rights, tax audits, assessments and settlements, pricing matters, sales and promotional practices, product liability, investigations and other matters; • our ability to commercialize biosimilars, which is subject to risks such as our reliance on third parties, competitive challenges, regulatory compliance, adequate supply, intellectual property and regulatory challenges and failure to gain market and patient acceptance; • our ability to finance our present and future operations and business initiatives and obtain funding for such activities on favorable terms; • our ability to attract, retain and motivate qualified individuals for management and other employee positions in a highly competitive environment, including potential difficulty in retaining talent following acquisitions or following the discontinuation or underperformance of one or more marketed, pre-clinical or clinical programs; • adverse safety events involving our marketed or pipeline products, generic, prodrugs or biosimilar versions of our marketed products or any other products from the same class as one of our products; • the current and potential impacts of geopolitical tensions, acts of war and other large-scale crises, including impacts to our operations, sales and the possible disruptions or delay in our plans to conduct clinical trial activities in areas of geopolitical tension, including tensions between the U.S., China and other countries, regions affected by Russia's invasion of Ukraine and the military conflict in the Middle East; • the direct and indirect impact of global health outbreaks or adverse weather events on our business and operations, including sales, expense, reserves and allowances, the supply chain, manufacturing, research and development costs, clinical trials and employees; • our use of information technology systems and data and the potential impacts of any breakdowns, interruptions, invasions, corruptions, data breaches, destructions and/or other cybersecurity incidents of such systems or those of our business partners; • our incorporation of technologies using AI into some of our processes; • the potential impact of healthcare reform in the U.S., including the IRA (or other legislative or executive acts that may modify or replace the IRA, such as the OBBBA) and the impact of the IRA Medicare Part D redesign, and measures being taken worldwide designed to reduce healthcare costs and limit the overall level of government expenditures, including the impact of pricing actions and reduced reimbursement for our products, as well as the potential impact of legislative and regulatory changes and priorities, including actions related to the MFN drug pricing policy; 4 Table of Contents • our manufacturing capacity, including our ability to effectively manufacture biosimilars, reliance on third-party contract manufacturing organizations, plans and timing relating to changes in our manufacturing capabilities, our ability to adequately address global bulk supply risks, our ability to fully utilize our manufacturing facilities, including our Solothurn facility, activities in new or existing manufacturing facilities and the expected timeline for the gene therapy, clinical packaging and other manufacturing facility in RTP, North Carolina to be operational; • the impact of the continued uncertainty of the credit and economic conditions in certain countries and our ability to collect accounts receivable in such countries; • the impact of the increased volatility in the financial markets on our ability to obtain financing; • lease commitments, purchase obligations and the timing and satisfaction of other contractual obligations; • changes in our effective tax rate and obligations in various jurisdictions in which we are subject to taxation; and • the impact of new laws, regulatory actions, judicial decisions, accounting standards and tariffs or trade restrictions, including any newly imposed U.S. tariffs and any responsive non-U.S. tariffs applicable to our products or operations, as well as the potential global macroeconomic effect of tariffs or trade restrictions. These forward-looking statements involve risks and uncertainties, including those that are described in Part II, Item 1A. Risk Factors and Part I, Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations included in this report and elsewhere in this report, that could cause actual results to differ materially from those reflected in such statements. The factors identified above should not be construed as an exhaustive list of factors that could affect our future results and should be read in conjunction with the other cautionary statements that are included in our 2024 Form 10-K. Because some of these risks and uncertainties cannot be predicted or quantified and some are beyond our control, you should not rely on our forward-looking statements as predictions of future events and you should not place undue reliance on these statements. Moreover, we operate in a very competitive and rapidly changing environment, new risks and uncertainties may emerge from time to time and it is not possible for us to predict all risks nor identify all uncertainties. Forward-looking statements speak only as of the date of this report and are based on information and estimates available to us at this time. Except as required by law, we do not undertake any obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise. You should read this report with the understanding that our actual future results, performance, events and circumstances might be materially different from what we expect. NOTE REGARDING COMPANY AND PRODUCT REFERENCES References in this report to: • “Biogen,” the “company,” “we,” “us” and “our” refer to Biogen Inc. and its consolidated subsidiaries; and • “RITUXAN” refers to both RITUXAN (the trade name for rituximab in the U.S., Canada and Japan) and MabThera (the trade name for rituximab outside the U.S., Canada and Japan). NOTE REGARDING TRADEMARKS ADUHELM®, AVONEX®, BYOOVIZ®, PLEGRIDY®, QALSODY®, RITUXAN®, RITUXAN HYCELA®, SKYCLARYS®, SPINRAZA®, TECFIDERA®, TYSABRI® and VUMERITY® are registered trademarks of Biogen. BENEPALI™, FLIXABI™, FUMADERM™, IMRALDI™ and OPUVIZ™ are trademarks of Biogen. ACTEMRA®, COLUMVI®, ENBREL®, EYLEA®, GAZYVA®, LEQEMBI®, HUMIRA®, LUCENTIS®, LUNSUMIO®, OCREVUS®, REMICADE®, ZURZUVAE™ and other trademarks referenced in this report are the property of their respective owners. NOTE REGARDING DISCLOSURES From time to time, we have used, or expect in the future to use, our investor relations website (investors.biogen.com), the Biogen LinkedIn account (linkedin.com/company/biogen) and the Biogen X account (https://x.com/biogen) as a means of disclosing information to the public in a broad, non-exclusionary manner, including for purposes of the SEC’s Regulation Fair Disclosure (Reg FD). Accordingly, investors should monitor our investor relations website and these social media channels in addition to our press releases, SEC filings, public conference calls and websites, as the information posted on them could be material to investors. 5 Table of Contents DEFINED TERMS 2024 Form 10-K Annual Report on Form 10-K for the year ended December 31, 2024 2020 Share Repurchase Program Board of Directors authorized program to repurchase up to $5.0 billion of our common stock 2024 ESPP Biogen Inc. 2024 Employee Stock Purchase Plan 2015 ESPP Biogen Inc. 2015 Employee Stock Purchase Plan 2023 Term Loan $1.5 billion term loan credit agreement 2025 Senior Notes Senior Unsecured Notes Issued in May 2025 AbbVie AbbVie Inc. AI Artificial Intelligence Alcyone Alcyone Therapeutics, Inc. ALS Amyotrophic Lateral Sclerosis AMR Antibody-Mediated Rejection AOCI Accumulated Other Comprehensive Income (Loss) ASO Antisense Oligonucleotide ASU Accounting Standards Update BLA Biologics License Application CCPA California Consumer Privacy Act CLE Cutaneous Lupus Erythematosus CLL Chronic Lymphocytic Leukemia CMS Centers for Medicare & Medicaid Services CNS Central Nervous System CODM Chief Operating Decision Maker Convergence Convergence Pharmaceuticals Ltd. CRL Complete Response Letter CROs Contract Research Organizations DEA Drug Enforcement Agency Denali Denali Therapeutics Inc. District Court U.S. District Court for the District of Massachusetts DOJ U.S. Department of Justice EC European Commission Eisai Eisai Co., Ltd. EMA European Medicines Agency E.U. European Union FA Friedreich Ataxia FASB Financial Accounting Standards Board FCPA Foreign Corrupt Practices Act FDA U.S. Food and Drug Administration Fit for Growth Cost saving program initiated in 2023 G7 Group of Seven (comprised of Canada, France, Germany, Italy, Japan, the U.K. and the U.S.) Genentech Genentech, Inc. GILTI Global Intangible Low Tax Income GloBE Global Anti-Base Erosion GMP Good Manufacturing Practices HHS U.S. Department of Health and Human Services HI-Bio Human Immunology Biosciences, Inc. Humana Humana Inc. IgAN Immunoglobulin A Nephropathy IND Investigational New Drug 6 Table of Contents DEFINED TERMS (continued) IPR&D In-process Research and Development IRA Inflation Reduction Act of 2022 IT Information Technology IV Intravenous LEQEMBI Collaboration Agreement Amended and Restated Collaboration Agreement entered into by Biogen MA Inc. and Eisai Co., Ltd. on October 22, 2017, as amended on March 13, 2022 LRRK2 Leucine-Rich Repeat Kinase 2 MAA Marketing Authorization Application MDD Major Depressive Disorder MorphoSys MorphoSys AG MFN Most-Favored-Nation MS Multiple Sclerosis NDA New Drug Application Neurimmune Neurimmune SubOne AG OBBBA One Big Beautiful Bill Act OECD Organization for Economic Co-operation and Development ODD Orphan Drug Designation Organon Organon LLC PDUFA Prescription Drug User Fee Act PMN Primary Membranous Nephropathy PPACA Patient Protection and Affordable Care Act PPD Postpartum Depression PPMS Primary Progressive MS PRV Priority Review Voucher R&D Research and Development Reata Reata Pharmaceuticals, Inc. RMS Relapsing MS RNAi RNA interference RRMS Relapsing-Remitting MS RTP Research Triangle Park Sage Sage Therapeutics, Inc. Samsung Bioepis Samsung Bioepis Co., Ltd. Samsung BioLogics Samsung BioLogics Co., Ltd. Sangamo Sangamo Therapeutics, Inc. SEC U.S. Securities and Exchange Commission SG&A Selling, General and Administrative SLE Systemic Lupus Erythematosus SMA Spinal Muscular Atrophy SOD1 Superoxide Dismutase 1 Supernus Supernus Pharmaceuticals, Inc. SWISSMEDIC Swiss Agency for Therapeutic Products Transition Toll Tax A one-time mandatory deemed repatriation tax on accumulated foreign subsidiaries' previously untaxed foreign earnings U.K. United Kingdom U.S. United States U.S. GAAP Accounting Principles Generally Accepted in the U.S. VA Veterans Affairs Vanqua Vanqua Bio, Inc. VAT Value-added Tax 7 Table of Contents PART I FINANCIAL INFORMATION BIOGEN INC. AND SUBSIDIARIES CONDENSED CONSOLIDATED STATEMENTS OF INCOME (unaudited, in millions, except per share amounts) For the Three Months Ended September 30, For the Nine Months Ended September 30, 2025 2024 2025 2024 Revenue: Product revenue, net $ 1,846.9 $ 1,769.4 $ 5,452.1 $ 5,380.9 Revenue from anti-CD20 therapeutic programs 493.9 446.2 1,339.4 1,284.7 Alzheimer's collaboration revenue 42.7 18.6 130.6 33.2 Contract manufacturing, royalty and other revenue 151.2 231.6 689.1 522.4 Total revenue 2,534.7 2,465.8 7,611.2 7,221.2 Cost and expense: Cost of sales, excluding amortization and impairment of acquired intangible assets 674.4 638.7 1,908.7 1,726.9 Research and development 436.1 516.2 1,269.2 1,467.0 Acquired in-process research and development, upfront and milestone expense 2.1 26.5 249.4 42.5 Selling, general and administrative 594.8 588.4 1,751.1 1,723.7 Amortization and impairment of acquired intangible assets 135.7 130.3 378.4 295.5 Collaboration profit sharing/(loss reimbursement) 87.2 69.3 220.3 197.3 (Gain) loss on fair value remeasurement of contingent consideration 5.6 23.8 28.4 23.8 Restructuring charges 7.4 6.8 42.0 24.9 Gain on sale of priority review voucher, net — — — ( 88.6 ) Other (income) expense, net 34.1 14.8 151.2 193.7 Total cost and expense 1,977.4 2,014.8 5,998.7 5,606.7 Income before income tax (benefit) expense 557.3 451.0 1,612.5 1,614.5 Income tax (benefit) expense 90.8 62.5 270.7 249.0 Net income attributable to Biogen Inc. $ 466.5 $ 388.5 $ 1,341.8 $ 1,365.5 Net income per share: Basic earnings per share attributable to Biogen Inc. $ 3.18 $ 2.67 $ 9.16 $ 9.38 Diluted earnings per share attributable to Biogen Inc. $ 3.17 $ 2.66 $ 9.14 $ 9.35 Weighted-average shares used in calculating: Basic earnings per share attributable to Biogen Inc. 146.6 145.7 146.4 145.5 Diluted earnings per share attributable to Biogen Inc. 147.1 146.1 146.8 146.0 See accompanying notes to these unaudited condensed consolidated financial statements. 8 Table of Contents BIOGEN INC. AND SUBSIDIARIES CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (unaudited, in millions) For the Three Months Ended September 30, For the Nine Months Ended September 30, 2025 2024 2025 2024 Net income attributable to Biogen Inc. $ 466.5 $ 388.5 $ 1,341.8 $ 1,365.5 Other comprehensive income (loss): Unrealized gains (losses) on cash flow hedges, net of tax 26.5 ( 41.0 ) ( 137.1 ) ( 6.2 ) Unrealized gains (losses) on pension benefit obligation, net of tax — 0.3 1.0 0.2 Currency translation adjustments, net of tax ( 3.2 ) 41.0 57.5 14.0 Total other comprehensive income (loss), net of tax 23.3 0.3 ( 78.6 ) 8.0 Comprehensive income (loss) attributable to Biogen Inc. $ 489.8 $ 388.8 $ 1,263.2 $ 1,373.5 See accompanying notes to these unaudited condensed consolidated financial statements. 9 Table of Contents BIOGEN INC. AND SUBSIDIARIES CONDENSED CONSOLIDATED BALANCE SHEETS (unaudited, in millions, except per share amounts) As of September 30, 2025 As of December 31, 2024 ASSETS Current assets: Cash and cash equivalents $ 3,862.8 $ 2,375.0 Marketable securities 97.6 — Accounts receivable, net of allowance for doubtful accounts of $ 3.1 and $ 2.2 , respectively 1,374.1 1,404.8 Due from anti-CD20 therapeutic programs 475.9 464.0 Inventory 2,209.4 2,460.5 Other current assets 916.8 752.5 Total current assets 8,936.6 7,456.8 Property, plant and equipment, net 3,075.7 3,181.3 Operating lease assets 330.5 356.4 Intangible assets, net 9,331.9 9,691.2 Goodwill 6,490.7 6,478.9 Deferred tax asset 312.4 324.2 Investments and other assets 729.7 560.5 Total assets $ 29,207.5 $ 28,049.3 LIABILITIES AND EQUITY Current liabilities: Current portion of notes payable $ — $ 1,748.6 Taxes payable 103.3 548.3 Accounts payable 413.1 424.2 Accrued expense and other 2,773.6 2,807.7 Total current liabilities 3,290.0 5,528.8 Notes payable 6,285.1 4,547.2 Deferred tax liability 358.1 190.5 Long-term operating lease liabilities 305.0 334.5 Other long-term liabilities 761.8 732.3 Total liabilities 11,000.0 11,333.3 Commitments, contingencies and guarantees Equity: Biogen Inc. shareholders’ equity: Preferred stock, par value $ 0.001 per share — — Common stock, par value $ 0.0005 per share 0.1 0.1 Additional paid-in capital 797.7 569.4 Accumulated other comprehensive income (loss) ( 214.8 ) ( 136.2 ) Retained earnings 20,601.6 19,259.8 Treasury stock, at cost ( 2,977.1 ) ( 2,977.1 ) Total equity 18,207.5 16,716.0 Total liabilities and equity $ 29,207.5 $ 28,049.3 See accompanying notes to these unaudited condensed consolidated financial statements. 10 Table of Contents BIOGEN INC. AND SUBSIDIARIES CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW (unaudited, in millions) For the Nine Months Ended September 30, 2025 2024 Cash flow from operating activities: Net income $ 1,341.8 $ 1,365.5 Adjustments to reconcile net income to net cash flow from operating activities: Depreciation and amortization 579.7 489.2 Impairment of intangible assets 3.5 20.2 Excess and obsolescence charges related to inventory 13.9 68.7 Amortization of acquired inventory step-up 165.4 185.1 Share-based compensation 231.2 216.1 Contingent consideration 28.4 23.8 Deferred income taxes 194.7 ( 99.7 ) (Gain) loss on strategic investments 33.7 22.7 Gain on sale of priority review voucher, net — ( 88.6 ) Other 49.3 95.1 Changes in operating assets and liabilities, net of effects of business acquired: Accounts receivable 74.9 127.6 Due from anti-CD20 therapeutic programs ( 11.8 ) ( 15.9 ) Inventory ( 35.3 ) ( 207.4 ) Accrued expense and other current liabilities ( 32.7 ) ( 84.2 ) Income tax assets and liabilities ( 764.1 ) 62.1 Other changes in operating assets and liabilities, net ( 179.9 ) ( 65.7 ) Net cash flow provided by (used in) operating activities 1,692.7 2,114.6 Cash flow from investing activities: Purchases of property, plant and equipment ( 109.9 ) ( 114.4 ) Purchases of marketable securities ( 91.0 ) — Acquisition of HI-Bio, net of cash acquired — ( 1,074.8 ) Proceeds from sale of equity interest in Samsung Bioepis — 406.8 Proceeds from sale of priority review voucher — 88.6 Acquisitions of intangible assets ( 15.3 ) ( 179.1 ) Proceeds from sales of strategic investments 56.6 96.7 Other 20.2 ( 4.4 ) Net cash flow provided by (used in) investing activities ( 139.4 ) ( 780.6 ) Cash flow from financing activities: Payments related to issuance of stock for share-based compensation arrangements, net ( 13.0 ) ( 34.8 ) Proceeds from borrowings 1,733.1 — Repayments of borrowings ( 1,750.0 ) ( 650.0 ) Cash paid for contingent consideration ( 141.3 ) — Other 6.3 ( 6.6 ) Net cash flow provided by (used in) financing activities ( 164.9 ) ( 691.4 ) Net increase (decrease) in cash and cash equivalents 1,388.4 642.6 Effect of exchange rate changes on cash and cash equivalents 99.4 6.7 Cash and cash equivalents, beginning of the period 2,375.0 1,049.9 Cash and cash equivalents, end of the period $ 3,862.8 $ 1,699.2 See accompanying notes to these unaudited condensed consolidated financial statements. 11 Table of Contents BIOGEN INC. AND SUBSIDIARIES CONDENSED CONSOLIDATED STATEMENTS OF EQUITY (unaudited, in millions) For the Three Months Ended September 30, 2025 Preferred stock Common stock Additional paid-in capital Accumulated other comprehensive income (loss) Retained earnings Treasury stock Total equity Shares Amount Shares Amount Shares Amount Balance, June 30, 2025 — $ — 170.4 $ 0.1 $ 714.0 $ ( 238.1 ) $ 20,135.1 ( 23.8 ) $ ( 2,977.1 ) $ 17,634.0 Net income — — — — — — 466.5 — — 466.5 Other comprehensive income (loss), net of tax — — — — — 23.3 — — — 23.3 Issuance of common stock under stock option and stock purchase plans — — — — 6.5 — — — — 6.5 Issuance of common stock under stock award plan — — 0.1 — ( 1.2 ) — — — — ( 1.2 ) Compensation related to share-based payments — — — — 78.4 — — — — 78.4 Other — — — — — — — — — — Balance, September 30, 2025 — $ — 170.5 $ 0.1 $ 797.7 $ ( 214.8 ) $ 20,601.6 ( 23.8 ) $ ( 2,977.1 ) $ 18,207.5 For the Nine Months Ended September 30, 2025 Preferred stock Common stock Additional paid-in capital Accumulated other comprehensive income (loss) Retained earnings Treasury stock Total equity Shares Amount Shares Amount Shares Amount Balance, December 31, 2024 — $ — 169.5 $ 0.1 $ 569.4 $ ( 136.2 ) $ 19,259.8 ( 23.8 ) $ ( 2,977.1 ) $ 16,716.0 Net income — — — — — — 1,341.8 — — 1,341.8 Other comprehensive income (loss), net of tax — — — — — ( 78.6 ) — — — ( 78.6 ) Issuance of common stock under stock option and stock purchase plans — — 0.3 — 28.6 — — — — 28.6 Issuance of common stock under stock award plan — — 0.7 — ( 41.5 ) — — — — ( 41.5 ) Compensation related to share-based payments — — — — 240.6 — — — — 240.6 Other — — — — 0.6 — — — — 0.6 Balance, September 30, 2025 — $ — 170.5 $ 0.1 $ 797.7 $ ( 214.8 ) $ 20,601.6 ( 23.8 ) $ ( 2,977.1 ) $ 18,207.5 See accompanying notes to these unaudited condensed consolidated financial statements. 12 Table of Contents BIOGEN INC. AND SUBSIDIARIES CONDENSED CONSOLIDATED STATEMENTS OF EQUITY - (Continued) (unaudited, in millions) For the Three Months Ended September 30, 2024 Preferred stock Common stock Additional paid-in capital Accumulated other comprehensive income (loss) Retained earnings Treasury stock Total equity Shares Amount Shares Amount Shares Amount Balance, June 30, 2024 — $ — 169.5 $ 0.1 $ 407.5 $ ( 146.0 ) $ 18,604.6 ( 23.8 ) $ ( 2,977.1 ) $ 15,889.1 Net income — — — — — — 388.5 — — 388.5 Other comprehensive income (loss), net of tax — — — — — 0.3 — — — 0.3 Issuance of common stock under stock option and stock purchase plans — — — — 7.6 — — — — 7.6 Issuance of common stock under stock award plan — — — — ( 1.6 ) — — — — ( 1.6 ) Compensation related to share-based payments — — — — 75.0 — — — — 75.0 Other — — — — — — — — — — Balance, September 30, 2024 — $ — 169.5 $ 0.1 $ 488.5 $ ( 145.7 ) $ 18,993.1 ( 23.8 ) $ ( 2,977.1 ) $ 16,358.9 For the Nine Months Ended September 30, 2024 Preferred stock Common stock Additional paid-in capital Accumulated other comprehensive income (loss) Retained earnings Treasury stock Total Biogen Inc. shareholders’ equity Shares Amount Shares Amount Shares Amount Balance, December 31, 2023 — $ — 168.7 $ 0.1 $ 302.5 $ ( 153.7 ) $ 17,627.6 ( 23.8 ) $ ( 2,977.1 ) $ 14,799.4 Net income — — — — — — 1,365.5 — — 1,365.5 Other comprehensive income (loss), net of tax — — — — — 8.0 — — — 8.0 Issuance of common stock under stock option and stock purchase plans — — 0.2 — 31.2 — — — — 31.2 Issuance of common stock under stock award plan — — 0.6 — ( 66.0 ) — — — — ( 66.0 ) Compensation related to share-based payments — — — — 224.0 — — — — 224.0 Other — — — — ( 3.2 ) — — — — ( 3.2 ) Balance, September 30, 2024 — $ — 169.5 $ 0.1 $ 488.5 $ ( 145.7 ) $ 18,993.1 ( 23.8 ) $ ( 2,977.1 ) $ 16,358.9 See accompanying notes to these unaudited condensed consolidated financial statements. 13 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited) Note 1: Summary of Significant Accounting Policies References in these notes to "Biogen," the "company," "we," "us" and "our" refer to Biogen Inc. and its consolidated subsidiaries. Business Overview Biogen is a global biopharmaceutical company focused on discovering, developing and delivering innovative therapies for people living with serious and complex diseases. We have a broad portfolio of medicines to treat MS, have introduced the first approved treatment for SMA, co-developed treatments to address a defining pathology of Alzheimer’s disease and launched the first approved treatment to target a genetic cause of ALS. We market the first and only drug approved in the U.S., the E.U. and certain international markets for the treatment of FA in adults and adolescents aged 16 years and older. We are focused on advancing our pipeline in neurology, specialized immunology and rare diseases. We support our drug discovery and development efforts through internal research and development programs, external collaborations and acquisitions. Our marketed products include TECFIDERA, VUMERITY, AVONEX, PLEGRIDY and TYSABRI for the treatment of MS; SPINRAZA for the treatment of SMA; SKYCLARYS for the treatment of FA; and QALSODY for the treatment of ALS. We also have collaborations with Eisai on the commercialization of LEQEMBI for the treatment of Alzheimer's disease and Supernus on the commercialization of ZURZUVAE for the treatment of PPD. We have certain business and financial rights with respect to RITUXAN for the treatment of non-Hodgkin's lymphoma, CLL and other conditions; RITUXAN HYCELA for the treatment of non-Hodgkin's lymphoma and CLL; GAZYVA for the treatment of CLL, follicular lymphoma and, following its approval in October 2025, lupus nephritis; OCREVUS for the treatment of PPMS and RMS; LUNSUMIO for the treatment of relapsed or refractory follicular lymphoma; COLUMVI, a bispecific antibody for the treatment of non-Hodgkin's lymphoma; and have the option to add other potential anti-CD20 therapies, pursuant to our collaboration arrangements with Genentech, a wholly-owned member of the Roche Group. We commercialize a portfolio of biosimilars of advanced biologics including: BENEPALI, an etanercept biosimilar referencing ENBREL; IMRALDI, an adalimumab biosimilar referencing HUMIRA; FLIXABI, an infliximab biosimilar referencing REMICADE; and BYOOVIZ, a ranibizumab biosimilar referencing LUCENTIS, in certain international markets. We also have commercialization rights related to OPUVIZ, an aflibercept biosimilar referencing EYLEA, in certain international markets. For additional information on our collaboration arrangements, please read Note 19, Collaborative and Other Relationships, to these unaudited condensed consolidated financial statements (condensed consolidated financial statements). Basis of Presentation In the opinion of management, our condensed consolidated financial statements include all adjustments, consisting of normal recurring accruals, necessary for a fair statement of our financial statements for interim periods in accordance with U.S. GAAP. The information included in this quarterly report on Form 10-Q should be read in conjunction with our audited consolidated financial statements and the accompanying notes included in our 2024 Form 10-K. Our accounting policies are described in the Notes to Consolidated Financial Statements in our 2024 Form 10-K and updated, as necessary, in this report. The year-end condensed consolidated balance sheet data presented for comparative purposes was derived from our audited financial statements, but does not include all disclosures required by U.S. GAAP. The results of operations for the three and nine months ended September 30, 2025, are not necessarily indicative of the operating results for the full year or for any other subsequent interim period. We operate as one operating segment, focused on discovering, developing and delivering innovative therapies for people living with serious and complex diseases. During the first quarter of 2025 we began presenting acquired in-process research and development, upfront and milestone expense as a separate line item in our condensed consolidated statements of income. Acquired in-process research and development, upfront and milestone expense includes costs incurred in connection with collaboration and license agreements such as upfront and milestone payments and, when applicable, premiums on equity securities and asset acquisitions of acquired in-process research and development, which were previously 14 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) included in research and development expense. Prior periods have been reclassified to conform to the current period presentation. The reclassification had no impact on our total cost and expense, net income attributable to Biogen Inc., earnings per share or total equity. Consolidation Our condensed consolidated financial statements reflect our financial statements, those of our wholly-owned subsidiaries and variable interest entities where we are the primary beneficiary. For consolidated entities where we own or are exposed to less than 100.0 % of the economics, we record net income (loss) attributable to noncontrolling interests, net of tax in our condensed consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. Intercompany balances and transactions are eliminated in consolidation. In determining whether we are the primary beneficiary of a variable interest entity, we apply a qualitative approach that determines whether we have both (1) the power to direct the economically significant activities of the entity and (2) the obligation to absorb losses of, or the right to receive benefits from, the entity that could potentially be significant to that entity. We continuously assess whether we are the primary beneficiary of a variable interest entity as changes to existing relationships or future transactions may result in us consolidating or deconsolidating one or more of our collaborators or partners. Use of Estimates The preparation of our condensed consolidated financial statements requires us to make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, equity, revenue and expense and related disclosure of contingent assets and liabilities. On an ongoing basis we evaluate our estimates, judgments and assumptions. We base our estimates on historical experience and on various other assumptions that we believe are reasonable, the results of which form the basis for making judgments about the carrying values of assets, liabilities and equity and the amount of revenue and expense. Actual results may differ from these estimates. 15 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Significant Accounting Policies There have been no material changes to our significant accounting policies disclosed in Note 1, Summary of Significant Accounting Policies , to our audited consolidated financial statements included in our 2024 Form 10-K. New Accounting Pronouncements From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies that we adopt as of the specified effective date. Unless otherwise discussed below, we do not believe that the adoption of recently issued standards have had, or may have, a material impact on our condensed consolidated financial statements or disclosures. Standard Description Effective Date Effects on the financial statements ASU No. 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures This standard establishes incremental disaggregation of income tax disclosures pertaining to the effective tax rate reconciliation and income taxes paid. The amendments in this update are required to be applied on a prospective basis with the option to apply it retrospectively. Annual reporting for fiscal years beginning after December 15, 2024. Early adoption is permitted. We are currently evaluating the potential impact that this new standard will have on our consolidated financial statements and related disclosures, and expect to apply this standard prospectively upon adoption. ASU No. 2024-03, Income Statement (Subtopic 220-40): Reporting Comprehensive Income - Expense Disaggregation Disclosures This standard requires disclosure in the notes to the financial statements, at each interim and annual reporting period, of specified information about certain costs and expense including purchases of inventory, employee compensation, depreciation and intangible asset amortization included in each relevant expense caption. This standard also requires a qualitative description of the amounts remaining in relevant expense captions that are not separately disaggregated, as well as disclosure of the total amount of selling expenses, and, in annual reporting periods, an entity’s definition of selling expenses. Annual reporting for fiscal years beginning after December 15, 2026, and interim periods within fiscal years beginning after December 15, 2027. Early adoption is permitted. We are currently evaluating the potential impact that this new standard will have on our consolidated financial statements and related disclosures. ASU No. 2025-07, Derivatives and Hedging (Topic 815) and Revenue from Contracts with Customers (Topic 606): Derivatives Scope Refinements and Scope Clarification for Share-Based Noncash Consideration from a Customer in a Revenue Contract This standard refines and expands the existing scope exceptions that exclude certain contracts, including certain R&D funding arrangements, from derivative accounting, and clarifies the accounting for share-based noncash consideration received from a customer. Annual reporting for fiscal years beginning after December 15, 2026, and interim periods within those annual reporting periods. Early adoption is permitted. We have early adopted this new standard on a modified retrospective basis as of January 1, 2025. Adoption did not have a material impac t on our condensed consolidated financial statements and related disclosures. 16 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 2: Acquisitions Alcyone Therapeutics, Inc. In September 2025 we entered into a definitive agreement to acquire all of the issued and outstanding shares of Alcyone Therapeutics, Inc., a clinical-stage biotechnology company focused on pediatric care through precision CNS therapeutics and dosing platforms. Alcyone's lead asset is ThecaFlex DRx, an implantable subcutaneous port and catheter device being investigated for the intrathecal delivery of ASOs, which is designed to provide an alternative to repeat lumbar punctures in chronic intrathecal administration of medicines. We have agreed to pay an upfront cash payment of $ 85.0 million upon closing, plus additional potential amounts payable upon the achievement of certain milestones related to the development and regulatory approval of ThecaFlex DRx for administering SPINRAZA and additional pipeline products. We plan to account for this proposed acquisition as an asset acquisition as the value being acquired primarily relates to a single asset and plan to record the upfront payment within acquired in-process research and development, upfront and milestone expense within our condensed consolidated statements of income upon the completion of this proposed acquisition. We anticipate the proposed acquisition to close during the fourth quarter of 2025, subject to the satisfaction of customary closing conditions. U nder the terms of this proposed acquisition, we expect to oversee the end-to-end development, manufacturing and commercialization of ThecaFlex DRx . Alcyone's remaining therapeutic assets would be divested from Alcyone into Neela Therapeutics, Inc., a newly formed independent company, prior to the closing of this proposed acquisition. We anticipate to make a convertible debt investment of up to $ 5.0 million in Neela Therapeutics. Inc. Human Immunology Biosciences On July 2, 2024, we completed the acquisition of all of the issued and outstanding shares of HI-Bio, a privately-held clinical-stage biotechnology company focused on targeted therapies for patients with severe immune-mediated diseases. HI-Bio's lead asset, felzartamab, an anti-CD38 antibody, is currently being evaluated for several indications, including three leading indications, AMR, PMN and IgAN. Felzartamab has received Breakthrough Therapy Designation and ODD from the FDA for development in the treatment of PMN and AMR. Subsequent to our acquisition, felzartamab received ODD in the E.U. in IgAN and solid organ transplantation. The acquisition of HI-Bio is expected to augment our pipeline and build on our expertise in immunology. Under the terms of this acquisition, we paid shareholders of HI-Bio approximately $ 1.15 billion at closing and may pay up to a total of $ 650.0 million in contingent development and regulatory milestone payments. The $ 1.15 billion paid includes approximately $ 74.5 million related to HI-Bio's outstanding, non-vested equity awards, inclusive of employer taxes, of which $ 56.4 million was recognized as share-based compensation payments to settle non-vested equity awards attributable to the post-acquisition service period and therefore not reflected as a component of total purchase price paid. Of the total $ 56.4 million, we recognized approximately $ 42.5 million as a charge to research and development expense with the remaining $ 13.9 million as a charge to selling, general and administrative expense within our condensed consolidated statements of income for the three and nine months ended September 30, 2025 . These amounts were associated with the accelerated vesting of stock options and RSUs previously granted to HI-Bio employees and required no future services to vest. Upon closing we also paid an additional $ 43.7 million related to working capital adjustments as of the transaction close date, which was included as a component of total purchase price paid. We funded this acquisition through available cash on hand and accounted for this acquisition as a business combination using the acquisition method of accounting in accordance with ASC Topic 805, Business Combinations , and recorded assets acquired and liabilities assumed at their respective fair values as of the acquisition date. 17 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Purchase Price Consideration Total consideration transferred for the acquisition of HI-Bio is summarized as follows: (In millions) As of July 2, 2024 Cash consideration paid to HI-Bio shareholders (1) $ 1,137.3 Contingent consideration 485.1 Total consideration $ 1,622.4 (1) Represents total consideration paid to shareholders of HI-Bio of $ 1.15 billion, plus an additional $ 43.7 million related to working capital adjustments as of the transaction close date, less $ 56.4 million of cash paid for HI-Bio's outstanding, non-vested equity awards, inclusive of employer taxes, which were recognized as compensation attributable to the post-acquisition service period and therefore not reflected as a component of total consideration. Contingent Consideration: We may make certain contingent payments to the former shareholders of HI-Bio upon the achievement of certain development and regulatory milestones. As of the acquisition date, the maximum aggregate amount payable for these potential milestones was $ 650.0 million. The acquisition-date fair value of these milestones was approximately $ 485.1 million and was estimated utilizing a probability-adjusted discounted cash flow calculation using an appropriate discount rate dependent on the nature and timing of the milestone payments, which ranged from 6.2 % to 7.0 %, and probabilities of technological and regulatory success ranging from 67.0 % to near-certain probability. Of the total contingent consideration, approximately $ 279.3 million related to milestones classified as short-term and reflected as a component of accrued expense and other with the remaining $ 205.8 million reflected as a component of other long-term liabilities within our condensed consolidated balance sheets. The short-term liability related to the fourth patient dosed in a Phase 3 clinical trial of felzartamab in a first and s econd indication, which would each result in the achievement of a $ 150.0 million milestone payment. During the second quarter of 2025 the first milestone related to the fourth patient dosed in a phase 3 clinical trial of felzartamab for AMR was achieved, resulting in a $ 150.0 million milestone payment made to the former shareholders of HI-Bio, which was paid during the third quarter of 2025. In October 2025 the second milestone related to the fourth patient dosed in a phase 3 clinical trial of felzartamab for IgAN was achieved, resulting in a $ 150.0 million milestone payment to be made to the former shareholders of HI-Bio, which we expect will be paid during the fourth quarter of 2025. Subsequent changes in the fair value of the contingent consideration obligation are being recognized as (gain) loss on fair value remeasurement of contingent consideration within our condensed consolidated statements of income. This fair value measurement is based on significant inputs that are not observable in the market and thus represent Level 3 fair value measurements. For additional information related to the fair value of this obligation, please read Note 8, Fair Value Measurements , to these condensed consolidated financial statements. Other Contractual Commitments: We acquired HI-Bio's pre-existing in-license commitments under third-party agreements with MorphoSys, which included tiered royalties on potential future sales ranging from high-single digit to mid-teen percentages, as well as potential development, regulatory and commercial milestone payments of up to $ 130.0 million, $ 230.0 million and $ 640.0 million, respectively. At the transaction close date the achievement of these milestones was not considered probable and therefore not recorded in our financial statements. 18 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Purchase Price Allocation We finalized purchase accounting for this acquisition in the second quarter of 2025. The following table summarizes the amounts recognized for assets acquired and liabilities assumed as of the acquisition date, and reflects measurement period adjustments made to the amounts initially recorded as of the acquisition date on July 2, 2024. The related impact to our condensed consolidated statements of income that would have been recognized in previous periods if the adjustments were recognized as of the acquisition date is immaterial. (In millions) Amounts Recognized as of Acquisition Date (as adjusted) Cash and cash equivalents $ 62.5 Intangible assets: IPR&D - felzartamab (IgAN) 920.0 IPR&D - felzartamab (AMR) 450.0 IPR&D - felzartamab (PMN) 265.0 Other clinical programs 7.9 Prepaid expense and other assets (1) 1.4 Operating lease assets 1.2 Accounts payable ( 1.1 ) Accrued liabilities ( 35.0 ) Deferred tax liability (1) ( 309.3 ) Operating lease liabilities ( 1.2 ) Total identifiable net assets 1,361.4 Goodwill (1) 261.0 Total assets acquired and liabilities assumed $ 1,622.4 (1) Includes measurement period adjustments recorded in 2025 that increased prepaid expense and other assets by $ 0.4 million, net deferred tax liability by $ 4.9 million and goodwill by $ 4.5 million. Intang ible assets: Intangible assets comprised of approximately $ 1.6 billion of IPR&D related to HI-Bio's lead asset felzartamab. This includes $ 920.0 million of IPR&D related to felzartamab indication for IgAN, $ 450.0 million of IPR&D related to felzartamab indication for AMR and $ 265.0 million of IPR&D related to felzartamab indication for PMN. The estimated fair values of the program related intangible assets were determined using a multi-period excess earnings method, a form of the income approach, utilizing cash flow analyses and a discount rate of 14.5 %. These fair value measurements were based on significant inputs that are not observable in the market and thus represent Level 3 fair value measurements. Goodwill: Goodwill was calculated as the excess of the consideration transferred over the net assets recognized and represents the future economic benefits arising from the other assets acq uired that could not be individually identified and separately recognized. We recognized goodwill of approximately $ 261.0 million, which includes measurement period adjustments, and is not deductible for tax purposes. The goodwill recognized from our acquisition of HI-Bio is primarily the result of the deferred tax consequences from the transaction recorded for financial statement purposes. Acquisition-related expense: Acquisition-related expense, primarily comprised of advisory and legal fees, and other transaction costs, totaled approximately $ 2.8 million and were recorded within selling, general and administrative expense within our consolidated statements of income for the year ended December 31, 2024, included in our 2024 Form 10-K . 19 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 3: Dispositions Sale of Joint Venture Equity Interest in Samsung Bioepis In April 2022 we completed the sale of our 49.9 % equity interest in Samsung Bioepis to Samsung BioLogics in exchange for total consideration of approximately $ 2.3 billion. Under the terms of this transaction, we received approximately $ 1.0 billion in cash at closing, with approximately $ 1.3 billion in cash to be deferred over two payments. The first deferred payment of $ 812.5 million was received in April 2023 and the second deferred payment of $ 437.5 million was received in April 2024. For the nine months ended September 30, 2024, we recognized a gain of approximately $ 7.5 million to reflect the change in fair value associated with the passage of time related to the second deferred payment due to us, which was received in April 2024 and recorded in other (income) expense, net within our condensed consolidated statements of income. For additional information on the sale of our equity interest in Samsung Bioepis, please read Note 3, Dispositions , to our consolidated financial statements included in our 2024 Form 10-K. Sale of Priority Review Voucher In April 2024 we completed the sale of our rare pediatric disease PRV, generated by the development associated with SPINRAZA, to a third party. In consideration for the PRV we received a cash payment of $ 103.0 million upon the closing of the PRV purchase, of which approximately $ 14.4 million was paid to Ionis. Our net portion of approximately $ 88.6 million was recognized in gain on sale of priority review voucher, net within our condensed consolidated statements of income for the nine months ended September 30, 2024. Sale of TOFIDENCE In March 2025 we completed the sale of our regulatory and commercial rights in the U.S. for TOFIDENCE, a tocilizumab biosimilar referencing ACTEMRA, to Organon. Under the terms of this transaction, we received a payment of approximately $ 51.0 million in July 2025 a nd recognized a de minimis loss within our condensed consolidated statements of income for the nine months ended September 30, 2025. Note 4: Restructuring 2023 Fit for Growth Restructuring Program In 2023 we initiated cost saving measures as part of our Fit for Growth program to reduce operating costs, while improving operating efficiency and effectiveness. The Fit for Growth program is expected to generate approximately $ 1.0 billion in gross operating expense savings by the end of 2025, some of which will be reinvested in various initiatives. The Fit for Growth program is currently estimated to include net headcount reductions of approximately 1,400 employees and we expect to incur total restructuring charges of approximately $ 310.0 million, which were substantially achieved as of September 30, 2025. 20 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Total charges incurred from our 2023 Fit for Growth program are summarized as follows: For the Three Months Ended September 30, 2025 2024 (In millions) Severance Costs Accelerated Depreciation and Other Costs Total Severance Costs Accumulated Depreciation and Other Costs Total Selling, general and administrative $ — $ 0.4 $ 0.4 $ — $ 9.1 $ 9.1 Research and development — 0.5 0.5 — 3.5 3.5 Restructuring charges 7.4 — 7.4 4.6 — 4.6 Total charges $ 7.4 $ 0.9 $ 8.3 $ 4.6 $ 12.6 $ 17.2 For the Nine Months Ended September 30, 2025 2024 (In millions) Severance Costs Accelerated Depreciation and Other Costs Total Severance Costs Accumulated Depreciation and Other Costs Total Selling, general and administrative $ — $ ( 2.8 ) $ ( 2.8 ) $ — $ 12.5 $ 12.5 Research and development — 6.9 6.9 — 10.6 10.6 Restructuring charges 41.6 — 41.6 20.2 — 20.2 Total charges $ 41.6 $ 4.1 $ 45.7 $ 20.2 $ 23.1 $ 43.3 Other Costs: Includes costs associated with items such as asset abandonment and write-offs, facility closure costs, pre-tax gains and losses resulting from the termination of certain leases, employee non-severance expense, consulting fees and other costs. Reata Integration Following the close of our Reata acquisition in September 2023, we implemented an integration plan designed to realize operating synergies through cost savings and avoidance. Under this initiative, we estimated we would incur total integration charges of approximately $ 35.0 million related to severance and employment costs, which were substantially incurred during 2023. Total charges incurred from our Reata integration are summarized as follows: For the Three Months Ended September 30, 2025 2024 (In millions) Severance Costs Accelerated Depreciation and Other Costs Total Severance Costs Accumulated Depreciation and Other Costs Total Selling, general and administrative $ — $ 1.6 $ 1.6 $ — $ 1.6 $ 1.6 Research and development — 3.8 3.8 — 2.9 2.9 Restructuring charges — — — 0.7 — 0.7 Total charges $ — $ 5.4 $ 5.4 $ 0.7 $ 4.5 $ 5.2 For the Nine Months Ended September 30, 2025 2024 (In millions) Severance Costs Accelerated Depreciation and Other Costs Total Severance Costs Accumulated Depreciation and Other Costs Total Selling, general and administrative $ — $ 5.2 $ 5.2 $ — $ 4.9 $ 4.9 Research and development — 10.1 10.1 — 8.9 8.9 Restructuring charges ( 0.2 ) — ( 0.2 ) 3.2 — 3.2 Total charges $ ( 0.2 ) $ 15.3 $ 15.1 $ 3.2 $ 13.8 $ 17.0 21 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) In connection with our acquisition of Reata we assumed responsibility for a single-tenant, build-to-suit building of approximately 327,400 square feet of office and laboratory space located in Plano, Texas, with an initial lease term of 16 years. We do not intend to occupy this building and are evaluating opportunities to sublease the property. For additional information on our acquisition of Reata, please read Note 2, Acquisitions , to our consolidated financial statements included in our 2024 Form 10-K. Restructuring Reserve Charges and spending related to workforce reductions are summarized as follows: Workforce Reductions (In millions) 2025 2024 Restructuring reserve as of January 1 $ 31.9 $ 75.4 Expense 35.3 11.5 Payment ( 25.8 ) ( 42.2 ) Foreign currency and other adjustments ( 1.0 ) 0.8 Restructuring reserve as of March 31 40.4 45.5 Expense ( 0.7 ) 6.6 Payment ( 9.5 ) ( 11.9 ) Foreign currency and other adjustments ( 1.0 ) — Restructuring reserve as of June 30 29.2 40.2 Expense 7.4 6.8 Payment ( 17.4 ) ( 4.7 ) Foreign currency and other adjustments — ( 2.1 ) Restructuring reserve as of September 30 $ 19.2 $ 40.2 22 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 5: Revenue Product Revenue Revenue by product is summarized as follows: For the Three Months Ended September 30, 2025 2024 (In millions) United States Rest of World Total United States Rest of World Total Multiple Sclerosis: TECFIDERA $ 44.6 $ 123.6 $ 168.2 $ 40.1 $ 192.7 $ 232.8 VUMERITY 189.6 25.0 214.6 134.9 23.2 158.1 Total Fumarate 234.2 148.6 382.8 175.0 215.9 390.9 AVONEX 133.4 55.1 188.5 115.6 60.6 176.2 PLEGRIDY 27.8 30.6 58.4 27.9 33.4 61.3 Total Interferon 161.2 85.7 246.9 143.5 94.0 237.5 TYSABRI 247.5 184.3 431.8 227.5 178.6 406.1 FAMPYRA (1) — — — — 19.4 19.4 Subtotal: Multiple Sclerosis 642.9 418.6 1,061.5 546.0 507.9 1,053.9 Rare Disease: SPINRAZA 153.2 220.8 374.0 153.1 228.3 381.4 SKYCLARYS (2) 74.6 58.3 132.9 81.8 20.5 102.3 QALSODY (3) 7.3 19.1 26.4 5.5 5.6 11.1 Subtotal: Rare Disease 235.1 298.2 533.3 240.4 254.4 494.8 Biosimilars: BENEPALI — 121.9 121.9 — 118.1 118.1 IMRALDI — 52.6 52.6 — 54.1 54.1 FLIXABI — 15.3 15.3 — 16.2 16.2 BYOOVIZ 2.0 5.0 7.0 4.1 3.9 8.0 TOFIDENCE — — — 0.2 — 0.2 Subtotal: Biosimilars 2.0 194.8 196.8 4.3 192.3 196.6 Other: ZURZUVAE 55.3 — 55.3 22.0 — 22.0 Other (4) — — — 0.3 1.8 2.1 Subtotal: Other 55.3 — 55.3 22.3 1.8 24.1 Total product revenue, net $ 935.3 $ 911.6 $ 1,846.9 $ 813.0 $ 956.4 $ 1,769.4 (1) Effective January 1, 2025, our collaboration and license agreement for FAMPYRA global commercialization rights was terminated. (2) SKYCLARYS became commercially available in the E.U. during the first quarter of 2024. (3) QALSODY became commercially available in the E.U. during the second quarter of 2024. (4) Other includes FUMADERM and ADUHELM. 23 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) For the Nine Months Ended September 30, 2025 2024 (In millions) United States Rest of World Total United States Rest of World Total Multiple Sclerosis: TECFIDERA $ 131.6 $ 436.3 $ 567.9 $ 127.9 $ 611.4 $ 739.3 VUMERITY 494.7 71.0 565.7 385.0 66.4 451.4 Total Fumarate 626.3 507.3 1,133.6 512.9 677.8 1,190.7 AVONEX 363.7 169.3 533.0 344.0 193.5 537.5 PLEGRIDY 80.2 106.7 186.9 84.7 109.8 194.5 Total Interferon 443.9 276.0 719.9 428.7 303.3 732.0 TYSABRI 720.5 547.4 1,267.9 690.0 609.6 1,299.6 FAMPYRA (1) — 0.3 0.3 — 57.3 57.3 Subtotal: Multiple Sclerosis 1,790.7 1,331.0 3,121.7 1,631.6 1,648.0 3,279.6 Rare Disease: SPINRAZA 456.9 733.7 1,190.6 458.9 692.9 1,151.8 SKYCLARYS (2) 221.7 165.4 387.1 230.4 49.9 280.3 QALSODY (3) 22.3 39.6 61.9 14.5 6.2 20.7 Subtotal: Rare Disease 700.9 938.7 1,639.6 703.8 749.0 1,452.8 Biosimilars: BENEPALI — 345.3 345.3 — 354.1 354.1 IMRALDI — 146.7 146.7 — 162.1 162.1 FLIXABI — 42.7 42.7 — 47.1 47.1 BYOOVIZ 8.7 15.8 24.5 18.1 9.2 27.3 TOFIDENCE 0.1 — 0.1 1.0 — 1.0 Subtotal: Biosimilars 8.8 550.5 559.3 19.1 572.5 591.6 Other: ZURZUVAE 129.4 — 129.4 49.3 — 49.3 Other (4) 0.4 1.7 2.1 2.0 5.6 7.6 Subtotal: Other 129.8 1.7 131.5 51.3 5.6 56.9 Total product revenue, net $ 2,630.2 $ 2,821.9 $ 5,452.1 $ 2,405.8 $ 2,975.1 $ 5,380.9 (1) Effective January 1, 2025, our collaboration and license agreement for FAMPYRA global commercialization rights was terminated. (2) SKYCLARYS became commercially available in the E.U. during the first quarter of 2024. (3) QALSODY became commercially available in the E.U. during the second quarter of 2024. (4) Other includes FUMADERM and ADUHELM. We recognized revenue from two wholesalers accounting for 27.8 % and 16.0 % of gross product revenue for the three months ended September 30, 2025, and 27.3 % and 15.4 % of gross product revenue for the nine months ended September 30, 2025. We recognized revenue from two wholesalers accounting for 25.9 % and 14.8 % of gross product revenue for the three months ended September 30, 2024, and 25.6 % and 12.9 % of gross product revenue for the nine months ended September 30, 2024. 24 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) An analysis of the change in reserves for discounts and allowances is summarized as follows: (In millions) Discounts Contractual Adjustments Returns Total Balance, December 31, 2024 $ 162.7 $ 880.8 $ 48.1 $ 1,091.6 Current provisions relating to sales in current year 607.4 2,052.6 20.7 2,680.7 Adjustments relating to prior years 1.8 ( 82.0 ) 1.0 ( 79.2 ) Payments/credits relating to sales in current year ( 497.3 ) ( 1,271.1 ) ( 0.5 ) ( 1,768.9 ) Payments/credits relating to sales in prior years ( 111.5 ) ( 479.2 ) ( 11.5 ) ( 602.2 ) Balance, September 30, 2025 $ 163.1 $ 1,101.1 $ 57.8 $ 1,322.0 The total reserves above, which are included in our condensed consolidated balance sheets, are summarized as follows: (In millions) As of September 30, 2025 As of December 31, 2024 Reduction of accounts receivable $ 259.7 $ 154.1 Component of accrued expense and other 1,062.3 937.5 Total revenue-related reserves $ 1,322.0 $ 1,091.6 Revenue from Anti-CD20 Therapeutic Programs Revenue from anti-CD20 therapeutic programs is summarized in the table below. For the purposes of this footnote, we refer to RITUXAN and RITUXAN HYCELA collectively as RITUXAN. For the Three Months Ended September 30, For the Nine Months Ended September 30, (In millions) 2025 2024 2025 2024 Royalty revenue on sales of OCREVUS $ 386.4 $ 346.8 $ 1,029.0 $ 985.8 Biogen’s share of pre-tax profits in the U.S. for RITUXAN, GAZYVA and LUNSUMIO 101.0 94.8 292.4 285.3 Other revenue from anti-CD20 therapeutic programs 6.5 4.6 18.0 13.6 Total revenue from anti-CD20 therapeutic programs $ 493.9 $ 446.2 $ 1,339.4 $ 1,284.7 For additional information on our collaboration arrangements with Genentech, please read Note 19, Collaborative and Other Relationships, to these condensed consolidated financial statements. Alzheimer's Collaboration Revenue Alzheimer's collaboration revenue consists of our 50.0 % share of LEQEMBI product revenue, net and cost of sales, including royalties, as we are not the principal. We began recognizing Alzheimer's collaboration revenue upon the accelerated approval of LEQEMBI in the U.S. during the first quarter of 2023. For the three and nine months ended September 30, 2025, we recognized Alzheimer's collaboration revenue of approximately $ 42.7 million and $ 130.6 million, respectively, compared to $ 18.6 million and $ 33.2 million, respectively, in the prior year comparative periods. For additional information on our collaboration arrangements with Eisai, please read Note 19, Collaborative and Other Relationships , to these condensed consolidated financial statements. 25 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Contract Manufacturing, Royalty and Other Revenue Contract manufacturing, royalty and other revenue is summarized as follows: For the Three Months Ended September 30, For the Nine Months Ended September 30, (In millions) 2025 2024 2025 2024 Contract manufacturing revenue $ 141.5 $ 221.9 $ 648.8 $ 474.1 Royalty and other revenue 9.7 9.7 40.3 48.3 Total contract manufacturing, royalty and other revenue $ 151.2 $ 231.6 $ 689.1 $ 522.4 Contract Manufacturing Revenue Contract manufacturing revenue primarily reflects amounts earned under contract manufacturing agreements with our strategic customers and batches of LEQEMBI related to our collaboration with Eisai. Royalty and Other Revenue Royalty and other revenue primarily reflects royalty revenue on biosimilar products from our license arrangements with Samsung Bioepis and royalties we receive from net sales on products related to patents that we have out-licensed. For additional information on our license arrangements with Samsung Bioepis and our collaboration arrangements with Eisai, please read Note 19, Collaborative and Other Relationships , to these condensed consolidated financial statements. Note 6: Inventory The components of inventory are summarized as follows: (In millions) As of September 30, 2025 As of December 31, 2024 Raw materials $ 296.2 $ 317.8 Work in process 1,635.0 1,882.8 Finished goods 440.5 353.8 Total inventory $ 2,371.7 $ 2,554.4 Balance Sheet Classification: Inventory $ 2,209.4 $ 2,460.5 Investments and other assets 162.3 93.9 Total inventory $ 2,371.7 $ 2,554.4 Long-term inventory is included in investments and other assets within our condensed consolidated balance sheets. As a result of our acquisition of Reata in September 2023 we recorded a fair value step-up adjustment related to the acquired inventory of SKYCLARYS of approximately $ 1.3 billion. This fair value step-up adjustment is being amortized to cost of sales within our condensed consolidated statements of income as the inventory is sold or used for clinical purposes. We expect this amount to be fully amortized by the end of 2028. For the three and nine months ended September 30, 2025, amortization from the fair value step-up adjustment was approximately $ 61.5 million and $ 165.4 million, respectively. For the three and nine months ended September 30, 2024, amortization from the fair value step-up adjustment was approximately $ 50.9 million and $ 185.1 million, respectively, which includes approximately $ 2.5 million and $ 48.5 million, respectively, of inventory used for clinical purposes, which is reflected in research and development expense within our condensed consolidated statements of income. For additional information on our acquisition of Reata, please read Note 2, Acquisitions , to our consolidated financial statements included in our 2024 Form 10-K. 26 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 7: Intangible Assets and Goodwill Intangible Assets Intangible assets, net of accumulated amortization, impairment charges and adjustments are summarized as follows: As of September 30, 2025 As of December 31, 2024 (In millions) Estimated Life Cost Accumulated Amortization Net Cost Accumulated Amortization Net Completed technology 2 - 31 years $ 14,087.2 $ ( 6,558.7 ) $ 7,528.5 $ 14,138.4 $ ( 6,254.1 ) $ 7,884.3 In-process research and development Indefinite until commercialization 1,639.4 — 1,639.4 1,642.9 — 1,642.9 Priority review voucher Indefinite 100.0 — 100.0 100.0 — 100.0 Trademarks and trade names Indefinite 64.0 — 64.0 64.0 — 64.0 Total intangible assets $ 15,890.6 $ ( 6,558.7 ) $ 9,331.9 $ 15,945.3 $ ( 6,254.1 ) $ 9,691.2 Amortization and Impairments For the three and nine months ended September 30, 2025, amortization and impairment of acquired intangible assets totale d $ 135.7 million and $ 378.4 million, respectively, compared to $ 130.3 million and $ 295.5 million, respectively, in the prior year comparative periods. For the three and nine months ended September 30, 2025, amortization of acquired intangible assets, excluding impairment charges, totaled $ 135.7 million and $ 374.9 million, respectively, compared to $ 110.1 million and $ 275.3 million, respectively, in the prior year comparative periods. Th e increases were primarily due to amortization for the acquired intangible assets associated with SKYCLARYS and TYSABRI. For the three months ended September 30, 2025, we had no impairment charges. For the nine months ended September 30, 2025, amortization and impairment of acquired intangible assets reflects the impact of a $ 3.5 million impairment charge related to a compound acquired from HI-Bio. For the three and nine months ended September 30, 2024, amortization and impairment of acquired intangible assets reflects impairment charges of approximately $ 20.2 million related to intangible assets associated with the termination of Samsung Bioepis' commercialization rights during the third quarter of 2024. Completed Technology Completed technology primarily relates to our other marketed products and programs acquired through asset acquisitions, licenses and business combinations. Completed technology intangible assets are amortized over their estimated useful lives, which range between 2 to 31 years, with a remaining weighted average useful life of 12 years. IPR&D Related to Business Combinations IPR&D represents the fair value assigned to research and development assets that we acquired as part of a business combination and had not yet reached technological feasibility at the date of acquisition. Included in IPR&D balances are adjustments related to foreign currency exchange rate fluctuations. The carrying value associated with our IPR&D assets as of September 30, 2025 and December 31, 2024, primarily relates to the IPR&D programs we acquired in connection with our acquisition of HI-Bio in July 2024, with an estimated fair value of approximately $ 1.6 billion. Priority Review Voucher In connection with our acquisition of Reata in September 2023 we acquired a rare pediatric disease PRV which may be used to obtain priority review by the FDA for a future regulatory submission or sold to a third party. We recorded the PRV based on its estimated fair value of $ 100.0 million as an intangible asset. 27 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Estimated Future Amortization of Intangible Assets The estimated future amortization of finite-lived intangible assets for the next five years is expected to be as follows: (In millions) As of September 30, 2025 2025 (remaining three months) $ 130.0 2026 485.0 2027 490.0 2028 525.0 2029 580.0 2030 650.0 Goodwill The following table provides a roll forward of the changes in our goodwill balance: (In millions) As of September 30, 2025 Goodwill, December 31, 2024 $ 6,478.9 Goodwill resulting from HI-Bio acquisition (1) 4.5 Other (2) 7.3 Goodwill, September 30, 2025 $ 6,490.7 (1) Goodwill resulting from the HI-Bio acquisition relates to HI-Bio measurement period adjustments recognized during 2025 related to certain income tax adjustments. For additional information on our acquisition of HI-Bio, please read Note 2, Acquisitions , to these condensed consolidated financial statements. (2) Other includes adjustments related to foreign currency exchange rate fluctuations. As of September 30, 2025, we had no impairment losses related to goodwill. 28 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 8: Fair Value Measurements The tables below present information about our assets and liabilities that are regularly measured and carried at fair value and indicate the level within the fair value hierarchy of the valuation techniques we utilized to determine such fair value: Fair Value Measurements on a Recurring Basis As of September 30, 2025 (In millions) Total Quoted Prices in Active Markets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Assets: Cash equivalents $ 3,398.8 $ — $ 3,398.8 $ — Marketable debt securities: Corporate debt securities 71.0 — 71.0 — Government securities 26.6 — 26.6 — Marketable equity securities 103.9 103.9 — — Other current assets: Derivative contracts 9.6 — 9.6 — Other non-current assets: Convertible note (1) 30.0 — — 30.0 Plan assets for deferred compensation 51.8 — 51.8 — Total $ 3,691.7 $ 103.9 $ 3,557.8 $ 30.0 Liabilities: Other current liabilities: Derivative contracts $ 89.1 $ — $ 89.1 $ — Contingent consideration obligations 148.6 — — 148.6 Other non-current liabilities: Derivative contracts 10.2 — 10.2 — Contingent consideration obligations 242.6 — — 242.6 Total $ 490.5 $ — $ 99.3 $ 391.2 (1) As part of our strategic research arrangement with City Therapeutics we invested in a convertible note, for which we elected the fair value option. For additional information on the arrangement with City Therapeutics, please read Note 19, Collaborative and Other Relationships, to these condensed consolidated financial statements. Fair Value Measurements on a Recurring Basis As of December 31, 2024 (In millions) Total Quoted Prices in Active Markets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Assets: Cash equivalents $ 1,664.9 $ — $ 1,664.9 $ — Marketable equity securities 179.7 179.7 — — Other current assets: Derivative contracts 62.5 — 62.5 — Other non-current assets: Plan assets for deferred compensation 42.8 — 42.8 — Total $ 1,949.9 $ 179.7 $ 1,770.2 $ — Liabilities: Other current liabilities: Derivative contracts $ 11.7 $ — $ 11.7 $ — Contingent consideration obligations 291.2 — — 291.2 Other non-current liabilities: Contingent consideration obligations 221.6 — — 221.6 Total $ 524.5 $ — $ 11.7 $ 512.8 29 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Our marketable equity securities represent investments in publicly traded equity securities. Our ability to liquidate our investment in Denali may be limited by the size of our interest, the volume of market-related activity, our concentrated level of ownership and potential restrictions resulting from our status as a collaborator. Therefore, we may realize significantly less than the current value of such investments. In July 2025 Sage was acquired by Supernus. Prior to this acquisition, we disposed of all of our shares of Sage common stock in a block trade. For additional information on our investments in Denali and Sage common stock, please read Note 19, Collaborative and Other Relationships , to our consolidated financial statements included in our 2024 Form 10-K. There have been no material impairments of our assets measured and carried at fair value as of September 30, 2025 and December 31, 2024. In addition, there have been no changes to our valuation techniques as of September 30, 2025 and December 31, 2024. For a description of our validation procedures related to prices provided by third-party pricing services and our option pricing valuation model, please read Note 1, Summary of Significant Accounting Policies - Fair Value Measurements, to our consolidated financial statements included in our 2024 Form 10-K. Level 3 Assets and Liabilities Held at Fair Value The following tables present quantitative information, as of the dates indicated, about the valuation techniques and significant unobservable inputs used in the valuation of our Level 3 financial assets and liabilities measured at fair value on a recurring basis: Quantitative Information about Level 3 Fair Value Measurements As of September 30, 2025 (In millions) Fair Value Valuation Technique Significant Unobservable Input(s) Range Weighted Average Liabilities: Contingent consideration obligations $ 391.2 Discounted cash flow Discount rate 5.4 % - 5.5 % 5.4 % Expected timing of achievement of development milestones 2025 - 2030 — Quantitative Information about Level 3 Fair Value Measurements As of December 31, 2024 (In millions) Fair Value Valuation Technique Significant Unobservable Input(s) Range Weighted Average Liabilities: Contingent consideration obligations $ 512.8 Discounted cash flow Discount rate 6.2 % - 6.3 % 6.2 % Expected timing of achievement of development milestones 2025 - 2030 — The weighted average discount rates were calculated based on the relative fair values of each distinct contingent consideration obligation related to our acquisition of HI-Bio in July 2024. In addition, we apply various probabilities of technological and regulatory success to the valuation models to estimate the fair values of these contingent consideration obligations, which ranged from approximately 70.0 % to near certain probability as of September 30, 2025 and December 31, 2024. There were no tr ansfers of assets or liabilities into or out of Level 3 as of September 30, 2025 and December 31, 2024. 30 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Contingent Consideration Obligations In connection with our acquisition of HI-Bio in July 2024 we agreed to make additional payments based upon the achievement of certain milestone events. The following table provides a roll forward of the fair value of our contingent consideration obligations, which were classified as Level 3 measurements: For the Three Months Ended September 30, For the Nine Months Ended September 30, (In millions) 2025 2024 2025 2024 Fair value, beginning of period $ 534.9 $ — $ 512.8 $ — Contingent consideration resulting from HI-Bio acquisition — 485.1 — 485.1 Changes in fair value 5.6 23.8 28.4 23.8 Payments ( 149.3 ) — ( 150.0 ) — Fair value, end of period $ 391.2 $ 508.9 $ 391.2 $ 508.9 Changes in the fair value of our contingent consideration obligations, other than changes due to payments, are recognized as a (gain) loss on fair value remeasurement of contingent consideration in our condensed consolidated statements of income. The fair values of the contingent consideration liabilities were based on a probability-adjusted discounted cash flow calculation using Level 3 fair value measurements and inputs. For additional information on the valuation techniques and inputs utilized in the valuation of our financial assets and liabilities, please read Note 1, Summary of Significant Accounting Policies , to our consolidated financial statements included in our 2024 Form 10-K. As of September 30, 2025 and December 31, 2024, approximately $ 148.6 million and $ 291.2 million, respectively, of the fair value of the total contingent consideration obligations were classified as short-term and reflected as a component of accrued expense and other with the remaining $ 242.6 million and $ 221.6 million, respectively, reflected as a component of other long-term liabilities in our condensed consolidated balance sheets. F or the three and nine months ended September 30, 2025 , changes in fair value of our contingent consideration obligations were primarily due to the passage of time. During the second quarter of 2025 the first milestone related to the fourth patient dosed in a phase 3 clinical trial of felzartamab for AMR was achieved, resulting in a $ 150.0 million milestone payment made to the former shareholders of HI-Bio, which was paid during the third quarter of 2025. In October 2025 the second milestone related to the fourth patient dosed in a phase 3 clinical trial of felzartamab for IgAN was achieved, resulting in a $ 150.0 million milestone payment to be made to the former shareholders of HI-Bio, which we expect will be paid during the fourth quarter of 2025. Financial Instruments Not Carried at Fair Value Other Financial Instruments Due to the short-term nature of certain financial instruments, the carrying value reflected in our condensed consolidated balance sheets for current accounts receivable, due from anti-CD20 therapeutic programs, other current assets, accounts payable and accrued expense and other, approximates fair value. 31 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Debt Instruments The fair and carrying values of our debt instruments, which are Level 2 liabilities, are summarized as follows: As of September 30, 2025 As of December 31, 2024 (In millions) Fair Value Carrying Value Fair Value Carrying Value Current portion: 4.050 % Senior Notes due September 15, 2025 (1) $ — $ — $ 1,741.0 $ 1,748.6 Current portion of notes payable — — 1,741.0 1,748.6 Non-current portion: 2.250 % Senior Notes due May 1, 2030 1,367.8 1,495.5 1,295.6 1,494.7 5.050 % Senior Notes due January 15, 2031 (1) 410.8 397.9 — — 5.750 % Senior Notes due May 15, 2035 (1) 680.2 645.4 — — 5.200 % Senior Notes due September 15, 2045 1,026.9 1,101.4 1,008.0 1,101.1 3.150 % Senior Notes due May 1, 2050 970.2 1,475.5 943.7 1,475.0 3.250 % Senior Notes due February 15, 2051 458.8 479.3 448.9 476.4 6.450 % Senior Notes due May 15, 2055 (1) 748.9 690.1 — — Non-current portion of notes payable 5,663.6 6,285.1 3,696.2 4,547.2 Total notes payable $ 5,663.6 $ 6,285.1 $ 5,437.2 $ 6,295.8 (1) In May 2025 we issued our 2025 Senior Notes for an aggregate principal amount of $ 1.75 billion. In June 2025 we used the net proceeds from the sale of our 2025 Senior Notes to redeem in full our 4.050 % Senior Notes due September 15, 2025, prior to maturity. For additional information, please read Note 13, Indebtedness , to these condensed consolidated financial statements. The fair values of each of our series of Senior Notes were determined through market, observable and corroborated sources. The changes in the fair values of our Senior Notes as of September 30, 2025, compared to December 31, 2024, are primarily related to decreases in U.S. treasury yields and credit spreads used to value our Senior Notes since December 31, 2024. For additional information related to our Senior Notes, please read Note 13, Indebtedness, to our consolidated financial statements included in our 2024 Form 10-K. Note 9: Financial Instruments The following table summarizes our financial assets with maturities of less than 90 days from the date of purchase included in cash and cash equivalents in our condensed consolidated balance sheets: (In millions) As of September 30, 2025 As of December 31, 2024 Money market funds $ 3,116.7 $ 1,664.9 Short-term debt securities 202.9 — Commercial paper 79.2 — Total $ 3,398.8 $ 1,664.9 The carrying values of our money market funds, short-term debt securities and commercial paper, including accrued interest, approximate fair value due to their short-term maturities. 32 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Our marketable equity securities gains (losses) are recorded in other (income) expense, net in our condensed consolidated statements of income. The following tables summarize our marketable debt and equity securities, classified as available-for-sale: As of September 30, 2025 (In millions) Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Marketable debt securities Corporate debt securities: Current $ 71.0 $ — $ — $ 71.0 Government securities: Current 26.6 — — 26.6 Total marketable debt securities $ 97.6 $ — $ — $ 97.6 Marketable equity securities Marketable equity securities, non-current $ 227.8 $ — $ ( 123.9 ) $ 103.9 Total marketable equity securities $ 227.8 $ — $ ( 123.9 ) $ 103.9 As of December 31, 2024 (In millions) Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Fair Value Marketable equity securities Marketable equity securities, non-current $ 668.7 $ — $ ( 489.0 ) $ 179.7 Total marketable equity securities $ 668.7 $ — $ ( 489.0 ) $ 179.7 Summary of Contractual Maturities: Available-for-Sale Debt Securities The estimated fair value and amortized cost of our marketable debt securities classified as available-for-sale by contractual maturity are summarized as follows: As of September 30, 2025 (In millions) Estimated Fair Value Amortized Cost Due in one year or less $ 97.6 $ 97.6 Total marketable debt securities $ 97.6 $ 97.6 The average maturity of our marketable debt securities classified as available-for-sale as of September 30, 2025, was approximately 2 months. Strategic Investments Our strategic investment portfolio includes investments in equity securities of certain biotechnology companies, which are reflected within our disclosures included in Note 8, Fair Value Measurements, to these condensed consolidated financial statements, as well as venture capital funds where the underlying investments are in equity securities of certain biotechnology companies and non-marketable equity securities. As of September 30, 2025 and December 31, 2024, our strategic investment portfolio was comprised of investments totaling $ 167.1 million and $ 226.7 million, respectively, which are included in investments and other assets within our condensed consolidated balance sheets. The decrease in our strategic investment portfolio as of September 30, 2025, compared to December 31, 2024, was primarily due to the decrease in the fair value of our investment in Denali common stock as well as the sale of our remaining investment in Sage common stock during the third quarter of 2025. For additional information on our investments in Denali and Sage common stock, please read Note 19, Collaborative and Other Relationships , to our consolidated financial statements included in our 2024 Form 10-K. 33 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 10: Derivative Instruments Foreign Currency Forward Contracts - Hedging Instruments Due to the global nature of our operations, portions of our revenue and operating expense are recorded in currencies other than the U.S. dollar. The value of revenue and operating expense measured in U.S. dollars is therefore subject to changes in foreign currency exchange rates. We enter into foreign currency forward contracts and foreign currency options with financial institutions with the primary objective to mitigate the impact of foreign currency exchange rate fluctuations on our international revenue and operating expense. Foreign currency forward contracts and foreign currency options in effect as of September 30, 2025 and December 31, 2024, had durations of 1 to 24 months and 1 to 12 months, respectively. These contracts have been designated as cash flow hedges and unrealized gains and losses on the portion of these foreign currency forward contracts and foreign currency options that are included in the effectiveness test are reported in AOCI. Realized gains and losses of such contracts and options are recognized in revenue when the sale of product in the currency being hedged is recognized and in operating expense when the expense in the currency being hedged is recorded. We recognize all cash flow hedge reclassifications from AOCI and fair value changes of excluded portions in the same line item in our condensed consolidated statements of income that have been impacted by the hedged item. The notional amount of foreign currency forward contracts and foreign currency options that were entered into to hedge forecasted revenue and operating expense is summarized as follows: Notional Amount (In millions) As of September 30, 2025 As of December 31, 2024 Euro $ 1,524.8 $ 1,062.6 British pound 35.0 133.8 Swiss franc 68.0 — Canadian dollar 9.9 38.6 Total foreign currency forward contracts and options $ 1,637.7 $ 1,235.0 The pre-tax portion of the fair value of these foreign currency forward contracts and foreign currency options that were included in AOCI in total equity is summarized as follows: (In millions) As of September 30, 2025 As of December 31, 2024 Unrealized gains $ 9.5 $ 50.6 Unrealized (losses) ( 112.9 ) ( 0.3 ) Net unrealized gains (losses) $ ( 103.4 ) $ 50.3 We expect net unrealized losses of approximately $ 103.4 million to be settled over the next 24 months, of which approximately $ 90.8 million of these net unrealized losses are expected to be settled over the next 12 months, with any amounts in AOCI to be reported as an adjustment to revenue or operating expense. We consider the impact of our and our counterparties’ credit risk on the fair value of the contracts as well as the ability of each party to execute its contractual obligations. As of September 30, 2025 and December 31, 2024, credit risk did not materially change the fair value of our foreign currency forward contracts and forward currency options. 34 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) The following tables summarize the effect of foreign currency forward contracts and forward currency options designated as hedging instruments in our condensed consolidated statements of income: For the Three Months Ended September 30, Net Gains/(Losses) Reclassified from AOCI into Operating Income (in millions) Net Gains/(Losses) Excluded from Effectiveness Testing and Recognized in Operating Income (in millions) Location 2025 2024 Location 2025 2024 Revenue $ ( 29.1 ) $ ( 7.6 ) Revenue $ 8.0 $ 2.9 Operating expense 6.7 ( 1.5 ) Operating expense — 0.3 For the Nine Months Ended September 30, Net Gains/(Losses) Reclassified from AOCI into Operating Income (in millions) Net Gains/(Losses) Excluded from Effectiveness Testing and Recognized in Operating Income (in millions) Location 2025 2024 Location 2025 2024 Revenue $ ( 41.1 ) $ 2.9 Revenue $ 7.6 $ 4.0 Operating expense 14.0 ( 8.5 ) Operating expense ( 1.8 ) ( 1.6 ) Foreign Currency Forward Contracts - Other Derivative Instruments We also enter into other foreign currency forward contracts, usually with durations of one month or less, to mitigate the foreign currency risk related to certain balance sheet positions. We have not elected hedge accounting for these transactions. The aggregate notional amount of these outstanding foreign currency forward contracts was $ 1,066.6 million and $ 738.7 million as of September 30, 2025 and December 31, 2024, respectively. Net losses of $ 0.5 million and net gains of $ 34.9 million related to these contracts were recorded as a component of other (income) expense, net for the three and nine months ended September 30, 2025, respectively, compared to net gains of $ 23.4 million and net losses of $ 6.6 million, respectively, in the prior year comparative periods. Summary of Derivative Instruments While certain of our derivative instruments are subject to netting arrangements with our counterparties, we do not offset derivative assets and liabilities in our condensed consolidated balance sheets. The amounts in the table below would not be substantially different if the derivative assets and liabilities were offset. The following table summarizes the fair value and presentation in our condensed consolidated balance sheets of our outstanding derivative instruments, including those designated as hedging instruments: (In millions) Balance Sheet Location As of September 30, 2025 As of December 31, 2024 Cash Flow Hedging Instruments: Asset derivative instruments Other current assets $ 7.8 $ 58.4 Liability derivative instruments Accrued expense and other 87.3 0.3 Other long-term liabilities 10.2 — Other Derivative Instruments: Asset derivative instruments Other current assets 1.8 4.1 Liability derivative instruments Accrued expense and other 1.8 11.4 Note 11: Property, Plant and Equipment Property, plant and equipment are recorded at historical cost, net of accumulated depreciation. Accumulated depreciation on property, plant and equipment was $ 2,868.4 million and $ 2,670.8 million as of September 30, 2025 and December 31, 2024, respectively. For the three and nine months ended September 30, 2025, depreciation expense totaled approximately $ 66.5 million and $ 204.8 million, respectively, compared to $ 72.7 million and $ 213.9 million, respectively, in the prior year comparative peri ods. 35 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 12: Leases New Corporate Headquarters Lease In March 2025 we entered into a lease agreement with MIT Investment Management Company and BioMed Realty for the lease of approximately 580,000 square feet of office and research and development space located at 75 Broadway, Cambridge, Massachusetts, which will be used as our new global corporate headquarters, as well as integrating our research and development and technical operations teams alongside our North American commercial organization. As part of a multi-year real estate consolidation plan that is expected to result in a reduction of approximately 40 % of our real estate footprint in Massachusetts, this new lease is intended to replace two existing leases, both in Cambridge, Massachusetts, including our current corporate headquarters. We expect the initial lease term of approximately 15.5 years to commence on May 31, 2028. The estimated minimum lease payments as a result of the new lease total approximately $ 1.5 billion over the initial lease term. We have an option to extend the lease for three extension periods of five years each and one six month short-term extension, at then market-based rates. We will account for this lease as a right-of-use asset and lease liability upon the lease commencement date. For additional information on our accounting policies relating to leases, please read Note 1, Summary of Significant Accounting Policies - Leases , to our consolidated financial statements included in our 2024 Form 10-K. Note 13: Indebtedness 2025 Senior Notes On May 12, 2025, we issued senior unsecured notes for an aggregate principal amount of $ 1.75 billion, consisting of the following: • $ 400.0 million of 5.050 % Senior Notes due January 15, 2031, valued at 99.981 % of par; • $ 650.0 million of 5.750 % Senior Notes due May 15, 2035, valued at 99.924 % of par; and • $ 700.0 million of 6.450 % Senior Notes due May 15, 2055, valued at 99.657 % of par. Our 2025 Senior Notes are senior unsecured obligations and may be redeemed at our option at any time at 100 % of the principal amount plus accrued interest and, until a specified period before maturity, a specified make-whole amount. Our 2025 Senior Notes contain a change-of-control provision that, under certain circumstances, may require us to purchase our 2025 Senior Notes at a price equal to 101 % of the principal amount plus accrued and unpaid interest to the date of repurchase. We incurred approximately $ 13.9 million of costs associated with this offering which have been recorded as a reduction to the carrying amount of the debt on our condensed consolidated balance sheets. These costs will be amortized as additional interest expense using the effective interest rate method over the period from issuance through maturity. The discounts will be amortized as additional interest expense over the period from issuance through maturity using the effective interest rate method. Interest on our 2031 Senior Notes is payable January 15 and July 15 of each year, commencing January 15, 2026. Interest on our 2035 Senior Notes and 2055 Senior Notes is payable May 15 and November 15 of each year, commencing on November 15, 2025. 4.050% Senior Notes due September 15, 2025 On September 15, 2015, we issued $ 1.75 billion aggregate principal amount of 4.050 % Senior Notes due September 15, 2025, at 99.764 % of par. In June 2025 we used the net proceeds from the sale of our 2025 Senior Notes to redeem our 4.050 % Senior Notes due September 15, 2025, prior to their maturity. No gain or loss was recognized upon redemption. 2023 Term Loan Credit Agreement In connection with our acquisition of Reata in September 2023 we entered into a $ 1.5 billion term loan credit agreement. On the closing date of the Reata acquisition we drew $ 1.0 billion from the 2023 Term Loan, comprised of a $ 500.0 million floating rate 364-day tranche and a $ 500.0 million floating rate three-year tranche. The remaining unused commitment of $ 500.0 million was terminated. As of December 31, 2023, we repaid 36 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) $ 350.0 million of the 364--day tranche. The remaining $ 150.0 million portion of the 364-day tranche was repaid during the first quarter of 2024. Additionally, during the first quarter of 2024 we repaid $ 250.0 million of the three-year tranche, with the remaining $ 250.0 million portion being subsequently repaid in full during the second quarter of 2024. For additional information on our acquisition of Reata, please read Note 2, Acquisitions , to our consolidated financial statements included in our 2024 Form 10-K. Note 14: Equity Share Repurchases In October 2020 our Board of Directors authorized our 2020 Share Repurchase Program, which is a program to repurchase up to $ 5.0 billion of our common stock. Our 2020 Share Repurchase Program does not have an expiration date. All shares repurchased under our 2020 Share Repurchase Program were retired. There were no share repurchases of our common stock during the three and nine months ended September 30, 2025 and 2024. Approximately $ 2.1 billion remained available under our 2020 Share Repurchase Program as of September 30, 2025. Accumulated Other Comprehensive Income (Loss) The following tables summarize the changes in AOCI, net of tax by component: For the Three Months Ended September 30, 2025 (In millions) Unrealized Gains (Losses) on Cash Flow Hedges, Net of Tax Unrealized Gains (Losses) on Pension Benefit Obligation, Net of Tax Currency Translation Adjustments, Net of Tax Total Balance, June 30, 2025 $ ( 112.0 ) $ ( 15.6 ) $ ( 110.5 ) $ ( 238.1 ) Other comprehensive income (loss) before reclassifications 6.3 — ( 3.2 ) 3.1 Amounts reclassified from AOCI 20.2 — — 20.2 Net current period other comprehensive income (loss) 26.5 — ( 3.2 ) 23.3 Balance, September 30, 2025 $ ( 85.5 ) $ ( 15.6 ) $ ( 113.7 ) $ ( 214.8 ) For the Nine Months Ended September 30, 2025 (In millions) Unrealized Gains (Losses) on Cash Flow Hedges, Net of Tax Unrealized Gains (Losses) on Pension Benefit Obligation, Net of Tax Currency Translation Adjustments Total Balance, December 31, 2024 $ 51.6 $ ( 16.6 ) $ ( 171.2 ) $ ( 136.2 ) Other comprehensive income (loss) before reclassifications ( 161.6 ) 1.0 57.5 ( 103.1 ) Amounts reclassified from AOCI 24.5 — — 24.5 Net current period other comprehensive income (loss) ( 137.1 ) 1.0 57.5 ( 78.6 ) Balance, September 30, 2025 $ ( 85.5 ) $ ( 15.6 ) $ ( 113.7 ) $ ( 214.8 ) 37 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) For the Three Months Ended September 30, 2024 (In millions) Unrealized Gains (Losses) on Cash Flow Hedges, Net of Tax Unrealized Gains (Losses) on Pension Benefit Obligation, Net of Tax Currency Translation Adjustments, Net of Tax Total Balance, June 30, 2024 $ 9.8 $ ( 2.7 ) $ ( 153.1 ) $ ( 146.0 ) Other comprehensive income (loss) before reclassifications ( 49.1 ) 0.3 41.0 ( 7.8 ) Amounts reclassified from AOCI 8.1 — — 8.1 Net current period other comprehensive income (loss) ( 41.0 ) 0.3 41.0 0.3 Balance, September 30, 2024 $ ( 31.2 ) $ ( 2.4 ) $ ( 112.1 ) $ ( 145.7 ) For the Nine Months Ended September 30, 2024 (In millions) Unrealized Gains (Losses) on Cash Flow Hedges, Net of Tax Unrealized Gains (Losses) on Pension Benefit Obligation, Net of Tax Currency Translation Adjustments Total Balance, December 31, 2023 $ ( 25.0 ) $ ( 2.6 ) $ ( 126.1 ) $ ( 153.7 ) Other comprehensive income (loss) before reclassifications ( 11.4 ) 0.2 14.0 2.8 Amounts reclassified from AOCI 5.2 — — 5.2 Net current period other comprehensive income (loss) ( 6.2 ) 0.2 14.0 8.0 Balance, September 30, 2024 $ ( 31.2 ) $ ( 2.4 ) $ ( 112.1 ) $ ( 145.7 ) The following table summarizes the amounts reclassified from AOCI: (In millions) Amounts Reclassified from AOCI Income Statement Location For the Three Months Ended September 30, For the Nine Months Ended September 30, 2025 2024 2025 2024 Gains (losses) on cash flow hedges $ ( 29.1 ) $ ( 7.6 ) $ ( 41.1 ) $ 2.9 Revenue 6.7 ( 1.5 ) 14.0 ( 8.5 ) Operating expense ( 0.1 ) ( 0.1 ) ( 0.3 ) ( 0.2 ) Other (income) expense, net 2.3 1.1 2.9 0.6 Income tax (benefit) expense Total reclassifications, net of tax $ ( 20.2 ) $ ( 8.1 ) $ ( 24.5 ) $ ( 5.2 ) 38 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) Note 15: Earnings per Share Basic and diluted shares outstanding used in our earnings per share calculation are calculated as follows: For the Three Months Ended September 30, For the Nine Months Ended September 30, (In millions) 2025 2024 2025 2024 Numerator: Net income attributable to Biogen Inc. $ 466.5 $ 388.5 $ 1,341.8 $ 1,365.5 Denominator: Weighted average number of common shares outstanding 146.6 145.7 146.4 145.5 Effect of dilutive securities: Time-vested restricted stock units 0.5 0.3 0.4 0.4 Performance stock units settled in stock — 0.1 — 0.1 Dilutive potential common shares 0.5 0.4 0.4 0.5 Shares used in calculating diluted earnings per share 147.1 146.1 146.8 146.0 Amounts excluded from the calculation of net income per diluted share because their effects were anti-dilutive were insignificant. Note 16: Share-Based Payments Share-based Compensation Expense The following table summarizes share-based compensation expense included in our condensed consolidated statements of income: For the Three Months Ended September 30, For the Nine Months Ended September 30, (In millions) 2025 2024 2025 2024 Research and development $ 28.8 $ 69.8 $ 91.0 $ 124.5 Selling, general and administrative 49.6 61.3 149.6 150.9 Subtotal 78.4 131.1 240.6 275.4 Capitalized share-based compensation costs ( 3.1 ) ( 2.4 ) ( 9.4 ) ( 8.0 ) Share-based compensation expense included in total cost and expense 75.3 128.7 231.2 267.4 Income tax effect ( 14.4 ) ( 24.2 ) ( 45.3 ) ( 50.5 ) Share-based compensation expense included in net income attributable to Biogen Inc. $ 60.9 $ 104.5 $ 185.9 $ 216.9 In connection with our acquisition of HI-Bio in July 2024 we recognized HI-Bio equity-based compensation expense, inclusive of employer taxes, of approximately $ 56.4 million attributable to the post-acquisition service period, of which $ 42.5 million was recognized as a charge to research and development expense with the remaining $ 13.9 million as a charge to selling, general and administrative expense within our condensed consolidated statements of income for the three and nine months ended September 30, 2024. These amounts were associated with the accelerated vesting of stock options and RSUs previously granted to HI-Bio employees and required no future services to vest. For additional information on our acquisition of HI-Bio, please read Note 2, Acquisitions , to these condensed consolidated financial statements. 39 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued) The following table summarizes share-based compensation expense associated with each of our share-based compensation programs: For the Three Months Ended September 30, For the Nine Months Ended September 30, (In millions) 2025 2024 2025 2024 Time-vested restricted stock units $ 60.1 $ 59.1 $ 186.8 $ 174.7 Performance stock units settled in stock 15.5 13.0 44.1 35.2 Employee stock purchase plan 1.8 1.9 6.9 8.2 Performance stock units settled in cash — ( 0.5 ) — ( 2.5 ) Stock options 1.0 1.0 2.8 2.8 Market stock units — 0.2 — 0.6 HI-Bio equity awards (1) — 56.4 — 56.4 Subtotal 78.4 131.1 240.6 275.4 Capitalized share-based compensation costs ( 3.1 ) ( 2.4 ) ( 9.4 ) ( 8.0 ) Share-based compensation expense included in total cost and expense $ 75.3 $ 128.7 $ 231.2 $ 267.4 (1) Relates to the HI-Bio equity-based compensation expense attributable to the post-acquisition service period, associated with the accelerated vesting of stock options and RSUs previously granted to HI-Bio employees and required no future services to vest. For additional information on our acquisition of HI-Bio, please read Note 2, Acquisitions , to these condensed consolidated financial statements. Note 17: Income Taxes 2025 OBBBA Tax Provisions On July 4, 2025, the U.S. signed into law the H.R.1 legislation formally titled "An Act to Provide for Reconciliation Pursuant to Title II of H. Con. Res. 14", commonly referred to as the OBBBA. The OBBBA contains tax provisions, such as the permanent extension or revision of certain expiring provisions of the Tax Cuts and Jobs Act enacted in 2017, modifications to the international tax framework and the restoration of favorable tax treatment for certain business provisions. The provisions of the OBBBA have multiple effective dates, with certain provisions effective in 2025 and others implemented through 2027. The OBBBA did not result in any material adjustments to our total income tax provision for the three and nine months ended September 30, 2025, and we have adjusted our deferred tax balances to reflect the impacts of the OBBBA enactment. Tax Rate A reconciliation between the U.S. federal statutory tax rate and our effective tax rate is summarized as follows: For the Three Months Ended September 30, For the Nine Months Ended September 30, 2025 2024 2025 2024 Statutory rate 21.0 % 21.0 % 21.0 % 21.0 % State taxes 1.7 2.5 1.7 1.7 Taxes on foreign earnings, including valuation allowances ( 5.0 ) ( 11.9 ) ( 7.2 ) ( 7.0 ) Tax credits ( 1.6 ) ( 1.2 ) ( 1.8 ) ( 1.7 ) Purchased inventory valuation step-up and intangible assets 2.4 3.3 2.3 2.0 GILTI ( 1.2 ) ( 1.1 ) ( 1.0 ) ( 1.4 ) Share-based compensation awards — — 1.1 0.2 OBBBA enactment ( 2.1 ) — ( 0.7 ) — Other, including permanent items 1.1 1.3 1.4 0.6 Effective tax rate 16.3 % 13.9 % 16.8 % 15.4 % 40 Table of Contents BIOGEN INC. AND SUBSIDIARIES NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited, continued)