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Table of Contents

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
________________________________________________________
FORM 10-Q
☒   QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
EXCHANGE ACT OF 1934
FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2026
or
☐   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
EXCHANGE ACT OF 1934
FOR THE TRANSITION PERIOD FROM              TO             
Commission file number  000-19319
____________________________________________
Vertex Pharmaceuticals Incorporated
(Exact name of registrant as specified in its charter)
Massachusetts
(State or other jurisdiction of incorporation or organization)
50 Northern Avenue , Boston , Massachusetts
(Address of principal executive offices)
04-3039129
(I.R.S. Employer Identification No.)
02210
(Zip Code)
Registrant’s telephone number, including area code ( 617 )  341-6100
 
____________________________________________

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading Symbol

Name of each exchange on which registered

Common Stock, $0.01 Par Value Per Share

VRTX

The Nasdaq Global Select Market

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and
(2) has been subject to such filing requirements for the past 90 days.   Yes   ☒ No  ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to
Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was
required to submit such files).  Yes   ☒ No  ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting
company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☒   Accelerated filer ☐   Non-accelerated filer ☐   Smaller reporting company ☐   Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.   ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).  Yes ☐  No ☒  
Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.

Common Stock, par value $0.01 per share

253,460,924

Outstanding at July 31, 2026

Table of Contents

VERTEX PHARMACEUTICALS INCORPORATED
FORM 10-Q
FOR THE QUARTER ENDED JUNE 30, 2026
TABLE OF CONTENTS

Page

Part I. Financial Information

Item 1.

Financial Statements (unaudited)

2

Condensed Consolidated Statements of Income

2

Condensed Consolidated Statements of Comprehensive Income

3

Condensed Consolidated Balance Sheets

4

Condensed Consolidated Statements of Shareholders' Equity

5

Condensed Consolidated Statements of Cash Flows

6

Notes to Condensed Consolidated Financial Statements

7

Item 2.

Management's Discussion and Analysis of Financial Condition and Results of Operations

22

Item 3.

Quantitative and Qualitative Disclosures About Market Risk

33

Item 4.

Controls and Procedures

33

Part II. Other Information

Item 1.

Legal Proceedings

34

Item 1A.

Risk Factors

34

Item 2.

Unregistered Sales of Equity Securities and Use of Proceeds

35

Item 5.

Other Information

36

Item 6.

Exhibits

38

Signatures

39

“Vertex,” “we,” “us,” and “our” as used in this Quarterly Report on Form 10-Q refer to Vertex Pharmaceuticals
Incorporated, a Massachusetts corporation, and its subsidiaries.
“Vertex ® ,” “KALYDECO ® ,” “ORKAMBI ® ,” “SYMDEKO ® ,” “SYMKEVI ® ,” “TRIKAFTA ® ,” “KAFTRIO ® ,”
CASGEVY ® , ” “ALYFTREK ® ,” and “JOURNAVX ® ” are registered trademarks of Vertex. Other brands, names and
trademarks contained in this Quarterly Report on Form 10-Q are the property of their respective owners.
We use the brand name for our products when we refer to the product that has been approved and with respect to the
indications on the approved label. Otherwise, including in discussions of our cystic fibrosis, sickle cell disease, beta
thalassemia, and pain development programs, we refer to our product candidates by their scientific (or generic) name or VX
developmental designation.

2

Table of Contents

Part I. Financial Information

Item 1.  Financial Statements

VERTEX PHARMACEUTICALS INCORPORATED
Condensed Consolidated Statements of Income
(unaudited; in millions, except per share amounts)

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

Revenues:

Product revenues, net

$ 3,333.9

$ 2,944.0

$ 6,320.8

$ 5,704.2

Other revenues

—

20.7

—

30.7

Total revenues

3,333.9

2,964.7

6,320.8

5,734.9

Costs and expenses:

Cost of sales

489.2

407.5

882.0

770.5

Research and development expenses

993.8

978.4

1,955.4

1,958.1

Acquired in-process research and development expenses

21.4

2.2

21.9

22.0

Selling, general and administrative expenses

582.2

424.6

1,075.9

821.0

Intangible asset impairment charge

—

—

—

379.0

Change in fair value of contingent consideration

0.4

0.9

0.6

3.1

Total costs and expenses

2,087.0

1,813.6

3,935.8

3,953.7

Income from operations

1,246.9

1,151.1

2,385.0

1,781.2

Interest income, net

120.6

118.7

235.4

236.6

Other income (expense) , net

24.3

13.2

24.3

( 4.4 )

Income before provision for income taxes

1,391.8

1,283.0

2,644.7

2,013.4

Provision for income taxes

292.0

250.1

513.5

334.2

Net income

$ 1,099.8

$ 1,032.9

$ 2,131.2

$ 1,679.2

Net income per common share:

Basic

$ 4.34

$ 4.02

$ 8.39

$ 6.54

Diluted

$ 4.31

$ 3.99

$ 8.33

$ 6.48

Shares used in per share calculations:

Basic

253.7

256.7

253.9

256.8

Diluted

255.2

258.9

255.7

259.2

The accompanying notes are an integral part of these condensed consolidated financial statements.

3

Table of Contents

VERTEX PHARMACEUTICALS INCORPORATED
Condensed Consolidated Statements of Comprehensive Income
(unaudited; in millions)

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

Net income

$ 1,099.8

$ 1,032.9

$ 2,131.2

$ 1,679.2

Other comprehensive income (loss) :

Unrealized holding (losses) gains on available-for-sale debt
securities, net of tax of $ 4.9 , $( 2.1 ) , $ 13.7 and $( 6.7 ) ,
respectively

( 17.4 )

7.4

( 48.6 )

23.9

Unrealized gains (losses) on foreign currency forward contracts,
net of tax of $( 11.2 ) , $ 54.1 , $( 35.1 ) and $ 79.7 , respectively

39.7

( 191.9 )

124.6

( 282.2 )

Foreign currency translation adjustment

1.4

15.3

( 11.6 )

29.4

Total other comprehensive income (loss)

23.7

( 169.2 )

64.4

( 228.9 )

Comprehensive income

$ 1,123.5

$ 863.7

$ 2,195.6

$ 1,450.3

The accompanying notes are an integral part of these condensed consolidated financial statements.

4

Table of Contents

VERTEX PHARMACEUTICALS INCORPORATED
Condensed Consolidated Balance Sheets
(unaudited; in millions, except share and per share data)

June 30, 2026

December 31, 2025

Assets

Current assets:

Cash and cash equivalents

$ 6,143.5

$ 5,084.8

Marketable securities

1,708.9

1,523.3

Accounts receivable, net

2,134.3

2,052.8

Inventories

1,765.1

1,686.8

Prepaid expenses and other current assets

791.9

853.3

Total current assets

12,543.7

11,201.0

Property and equipment, net

1,665.0

1,520.3

Goodwill

1,088.0

1,088.0

Other intangible assets, net

412.8

424.2

Deferred tax assets

3,010.9

2,897.9

Operating lease assets

1,662.9

1,562.7

Long-term marketable securities

5,789.1

5,712.3

Other assets

1,250.9

1,236.6

Total assets

$ 27,423.3

$ 25,643.0

Liabilities and Shareholders’ Equity

Current liabilities:

Accounts payable

$ 429.5

$ 461.7

Accrued expenses

3,179.0

2,971.2

Other current liabilities

329.4

428.3

Total current liabilities

3,937.9

3,861.2

Long-term operating lease liabilities

1,977.6

1,846.5

Other long-term liabilities

1,259.9

1,269.5

Total liabilities

7,175.4

6,977.2

Commitments and contingencies ( Note L )

Shareholders’ equity:

Preferred stock, $ 0.01 par value; 1,000,000 shares authorized; none issued

—

—

Common stock, $ 0.01 par value; 500,000,000 shares authorized, 253,347,555 and
253,991,224 shares issued and outstanding, respectively

2.5

2.5

Additional paid-in capital

4,505.7

5,119.2

Accumulated other comprehensive income (loss)

48.5

( 15.9 )

Retained earnings

15,691.2

13,560.0

Total shareholders’ equity

20,247.9

18,665.8

Total liabilities and shareholders’ equity

$ 27,423.3

$ 25,643.0

The accompanying notes are an integral part of these condensed consolidated financial statements.

5

Table of Contents

VERTEX PHARMACEUTICALS INCORPORATED
Condensed Consolidated Statements of Shareholders’ Equity
(unaudited; in millions)

Three Months Ended

Common Stock

Additional
Paid-in
Capital

Accumulated
Other
Comprehensive
Income (Loss)

Retained
Earnings

Total
Shareholders’
Equity

Shares

Amount

Balance at March 31, 2025

257.0

$ 2.6

$ 6,172.5

$ 68.1

$ 10,253.1

$ 16,496.3

Other comprehensive loss , net of tax

—

—

—

( 169.2 )

—

( 169.2 )

Net income

—

—

—

—

1,032.9

1,032.9

Repurchases of common stock

( 0.9 )

—

( 397.3 )

—

—

( 397.3 )

Common stock withheld for employee tax obligations

—

—

( 5.9 )

—

—

( 5.9 )

Issuance of common stock under benefit plans

0.2

—

47.4

—

—

47.4

Stock-based compensation expense

—

—

171.2

—

—

171.2

Balance at June 30, 2025

256.3

$ 2.6

$ 5,987.9

$ ( 101.1 )

$ 11,286.0

$ 17,175.4

Balance at March 31, 2026

254.2

$ 2.5

$ 4,743.2

$ 24.8

$ 14,591.4

$ 19,361.9

Other comprehensive income , net of tax

—

—

—

23.7

—

23.7

Net income

—

—

—

—

1,099.8

1,099.8

Repurchases of common stock

( 1.1 )

—

( 457.7 )

—

—

( 457.7 )

Common stock withheld for employee tax obligations

—

—

( 4.3 )

—

—

( 4.3 )

Issuance of common stock under benefit plans

0.2

—

50.6

—

—

50.6

Stock-based compensation expense

—

—

173.9

—

—

173.9

Balance at June 30, 2026

253.3

$ 2.5

$ 4,505.7

$ 48.5

$ 15,691.2

$ 20,247.9

Six Months Ended

Common Stock

Additional
Paid-in
Capital

Accumulated
Other
Comprehensive
Income (Loss)

Retained
Earnings

Total
Shareholders’
Equity

Shares

Amount

Balance at December 31, 2024

256.9

$ 2.6

$ 6,672.4

$ 127.8

$ 9,606.8

$ 16,409.6

Other comprehensive loss , net of tax

—

—

—

( 228.9 )

—

( 228.9 )

Net income

—

—

—

—

1,679.2

1,679.2

Repurchases of common stock

( 1.8 )

—

( 814.2 )

—

—

( 814.2 )

Common stock withheld for employee tax obligations

( 0.6 )

—

( 276.4 )

—

—

( 276.4 )

Issuance of common stock under benefit plans

1.8

—

65.9

—

—

65.9

Stock-based compensation expense

—

—

340.2

—

—

340.2

Balance at June 30, 2025

256.3

$ 2.6

$ 5,987.9

$ ( 101.1 )

$ 11,286.0

$ 17,175.4

Balance at December 31, 2025

254.0

$ 2.5

$ 5,119.2

$ ( 15.9 )

$ 13,560.0

$ 18,665.8

Other comprehensive income , net of tax

—

—

—

64.4

—

64.4

Net income

—

—

—

—

2,131.2

2,131.2

Repurchases of common stock

( 1.8 )

—

( 802.2 )

—

—

( 802.2 )

Common stock withheld for employee tax obligations

( 0.5 )

—

( 232.8 )

—

—

( 232.8 )

Issuance of common stock under benefit plans

1.6

—

77.7

—

—

77.7

Stock-based compensation expense

—

—

343.8

—

—

343.8

Balance at June 30, 2026

253.3

$ 2.5

$ 4,505.7

$ 48.5

$ 15,691.2

$ 20,247.9

The accompanying notes are an integral part of these condensed consolidated financial statements.

6

Table of Contents

VERTEX PHARMACEUTICALS INCORPORATED
Condensed Consolida ted Statements of Cash Flows
(unaudited; in millions)

Six Months Ended June 30,

2026

2025

Cash flows from operating activities:

Net income

$ 2,131.2

$ 1,679.2

Adjustments to reconcile net income to net cash provided by operating activities:

Stock-based compensation expense

336.6

333.4

Depreciation and amortization expense

112.4

100.1

Intangible asset impairment charge

—

379.0

Deferred income taxes

( 135.0 )

( 305.4 )

Other non-cash items, net

( 21.4 )

106.6

Changes in operating assets and liabilities:

Accounts receivable

( 100.4 )

( 188.0 )

Inventories

( 125.4 )

( 315.7 )

Prepaid expenses and other assets

122.0

( 104.5 )

Accounts payable

( 31.1 )

33.8

Accrued expenses

293.0

214.7

Other liabilities

( 28.4 )

( 41.2 )

Net cash provided by operating activities

2,553.5

1,892.0

Cash flows from investing activities:

Purchases of available-for-sale debt securities

( 4,864.1 )

( 3,820.6 )

Sales and maturities of available-for-sale debt securities

4,558.2

3,476.3

Purchases of property and equipment

( 245.6 )

( 186.4 )

Proceeds related to convertible note

75.5

—

Other investing activities

( 1.7 )

( 9.6 )

Net cash used in investing activities

( 477.7 )

( 540.3 )

Cash flows from financing activities:

Issuances of common stock under benefit plans

74.7

65.8

Repurchases of common stock

( 806.4 )

( 817.9 )

Payments in connection with common stock withheld for employee tax obligations

( 232.8 )

( 276.4 )

Other financing activities

( 1.0 )

( 1.1 )

Net cash used in financing activities

( 965.5 )

( 1,029.6 )

Effect of changes in exchange rates on cash

( 44.0 )

87.7

Net increase in cash, cash equivalents and restricted cash

1,066.3

409.8

Cash, cash equivalents and restricted cash—beginning of period

5,087.8

4,572.2

Cash, cash equivalents and restricted cash—end of period

$ 6,154.1

$ 4,982.0

Supplemental disclosure of cash flow information:

Cash paid for income taxes

$ 501.5

$ 697.7

Cash paid for interest

$ 6.3

$ 6.2

The accompanying notes are an integral part of these condensed consolidated financial statements.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

A. Basis of Presentation and Accounting Policies
Basis of Presentation
The accompanying condensed consolidated financial statements are unaudited and have been prepared by Vertex
Pharmaceuticals Incorporated (“Vertex,” “we,” “us” or “our”) in accordance with accounting principles generally accepted in
the United States of America (“U.S. GAAP”).
The condensed consolidated financial statements reflect the operations of Vertex and our wholly-owned subsidiaries. All
material intercompany balances and transactions have been eliminated. We operate in one segment , pharmaceuticals.
Certain information and footnote disclosures normally included in our Annual Report on Form 10-K for the fiscal year
ended December 31, 2025 (the “ 2025 Annual Report on Form 10-K”) have been condensed or omitted. These interim
financial statements, in the opinion of management, reflect all normal recurring adjustments necessary for a fair presentation
of the financial position and results of income for the interim periods ended June 30, 2026 and 2025 .
The results of operations for the interim period are not necessarily indicative of the results of operations to be expected
for the full fiscal year. These interim financial statements should be read in conjunction with the audited financial statements
for the year ended December 31, 2025 , which are contained in our 2025 Annual Report on Form 10-K .
Use of Estimates
The preparation of condensed consolidated financial statements in accordance with U.S. GAAP requires us to make
certain estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets
and liabilities at the date of our condensed consolidated financial statements, and the amounts of revenues and expenses
during the reported periods. We base our estimates on historical experience and various other assumptions, including in
certain circumstances future projections that we believe to be reasonable under the circumstances. Actual results could differ
from those estimates. Changes in estimates are reflected in reported results in the period in which they become known.
Recently Issued Accounting Standards
Disaggregation of Income Statement Expenses
In 2024, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2024-03,
Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40):
Disaggregation of Income Statement Expenses (“ASU 2024-03”), which requires public entities, among other items, to
disclose in a tabular format, on an annual and interim basis, purchases of inventory, employee compensation, depreciation,
intangible asset amortization and depletion for each income statement line item that contains those expenses. ASU 2024-03
becomes effective for the annual period starting on January 1, 2027 and interim periods starting on January 1, 2028. We are
in the process of analyzing the impact that the adoption of ASU 2024-03 will have on our disclosures.
Internal-Use Software
In 2025, the FASB issued ASU 2025-06, Intangibles—Goodwill and Other—Internal-Use Software (Subtopic 350-40):
Targeted Improvements to the Accounting for Internal-Use Software (“ASU 2025-06”), which eliminates consideration of the
software project development stages and replaces them with modernized recognition and measurement guidance designed to
reflect current internal-use software development practices. ASU 2025-06 becomes effective for the annual and interim
periods starting on January 1, 2028. We are in the process of analyzing the impact that the adoption of ASU 2025-06 will
have on our consolidated financial statements and related disclosures.
Summary of Significant Accounting Policies
Our significant accounting policies are described in Note A, “Nature of Business and Accounting Policies,” in our 2025
Annual Report on Form 10-K.

B. Collaboration, License and Other Arrangements
Acquired In-Process Research and Development
We have entered into numerous business development agreements with third parties to collaborate on research,
development and commercialization programs, license technologies, or acquire assets. Our “ Acquired in-process research and

8

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

development expenses ” (“AIPR&D”) included $ 21.4 million and $ 21.9 million in the three and six months ended June 30,
2026 , respectively, and $ 2.2 million and $ 22.0 million in the three and six months ended June 30, 2025 , respectively, related
to upfront, contingent milestone, or other payments pursuant to our business development transactions.
Our collaboration, licensing and asset acquisition agreements that had a significant impact on our financial statements for
the three and six months ended June 30, 2026 and 2025 or were new or materially revised during the three and six months
ended June 30, 2026 , are described below. Additional agreements are described in Note B, “Collaboration, License and Other
Arrangements,” of our 2025 Annual Report on Form 10-K.
In-license Agreements
CRISPR Therapeutics AG
We have a joint development and commercialization agreement (the “CRISPR JDCA”) with CRISPR Therapeutics AG
and its affiliates (“CRISPR”). Pursuant to the CRISPR JDCA, we lead global development, manufacturing and
commercialization of CASGEVY for the treatment of hemoglobinopathies, including treatments for severe sickle cell disease
(“SCD”) and transfusion-dependent beta thalassemia, with support from CRISPR.
We share with CRISPR 40 % of the net commercial profits or losses incurred with respect to CASGEVY, subject to
certain adjustments, which is recorded to “ Cost of sales .” The net commercial profits or losses equal the sum of the product
revenues, cost of sales and selling, general and administrative expenses that we recognized during the applicable period
related to the CRISPR JDCA. We also are reimbursed by CRISPR for its 40 % share of the research and development
activities conducted under the CRISPR JDCA, subject to certain adjustments, and we record this reimbursement from
CRISPR as a credit within “ Research and development expenses .”
In the first quarter of 2025, we recorded a $ 12.5  million credit to AIPR&D from CRISPR, reflecting its share of our
upfront payment paid to Orna Therapeutics in December 2024.
During the three and six months ended June 30, 2026 and 2025 , the credits recognized in our condensed consolidated
statements of income for CRISPR’s share of CRISPR JDCA activities were as follows:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

Cost of sales

$ 21.8

$ 30.1

$ 44.9

$ 66.3

Research and development expenses

$ 14.4

$ 15.1

$ 30.5

$ 31.1

Acquired in-process research and development expenses

$ —

$ —

$ —

$ 12.5

Cystic Fibrosis Foundation
In 2004, we entered into an agreement with the Cystic Fibrosis Foundation (the “CFF”), as successor in interest to the
Cystic Fibrosis Foundation Therapeutics, Inc., to support research and development activities. Pursuant to the agreement, as
amended, we have agreed to pay tiered royalties ranging from single digits to sub-teens on covered compounds first
synthesized and/or tested during a research term on or before February 28, 2014, including ivacaftor, lumacaftor and
tezacaftor, and royalties ranging from low-single digits to mid-single digits on net sales of certain compounds first
synthesized and/or tested between March 1, 2014 and August 31, 2016, including elexacaftor. We do not have any royalty
obligations on compounds first synthesized and tested on or after September 1, 2016. For combination products, such as
ORKAMBI, SYMDEKO/SYMKEVI, TRIKAFTA/KAFTRIO, and ALYFTREK, sales are allocated equally to each of the
active pharmaceutical ingredients in the combination product, and royalties are then paid for any royalty-bearing components
included in the combination. We record expenses related to these royalty obligations to “ Cost of sales .”

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

C. Earnings Per Share
The following table sets forth the computation of basic and diluted net income per common share for the periods ended:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions, except per share amounts)

Net income

$ 1,099.8

$ 1,032.9

$ 2,131.2

$ 1,679.2

Basic weighted-average common shares outstanding

253.7

256.7

253.9

256.8

Effect of potentially dilutive securities:

Restricted stock units (including performance-based restricted
stock units (“PSUs”))

0.9

1.3

1.2

1.4

Stock options

0.6

0.9

0.6

1.0

Diluted weighted-average common shares outstanding

255.2

258.9

255.7

259.2

Basic net income per common share

$ 4.34

$ 4.02

$ 8.39

$ 6.54

Diluted net income per common share

$ 4.31

$ 3.99

$ 8.33

$ 6.48

During the three and six months ended June 30, 2026 and 2025 , the number of anti-dilutive securities that were excluded
from the computation of our diluted net income per common share were as follows :

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

Unvested restricted stock units (including PSUs)

0.6

—

0.3

—

Stock options

—

—

—

—

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

D. Fair Value Measurements
The following table sets forth our financial assets and liabilities subject to fair value measurements by level within the
fair value hierarchy, as described in Note A, “Nature of Business and Accounting Policies,” of our 2025 Annual Report on
Form 10-K :

As of June 30, 2026

As of December 31, 2025

Fair Value Hierarchy

Fair Value Hierarchy

Total

Level 1

Level 2

Level 3

Total

Level 1

Level 2

Level 3

(in millions)

Financial instruments carried at fair value (asset positions):

Cash equivalents

$ 2,656.9

$ 1,351.5

$ 1,305.4

$ —

$ 2,779.1

$ 1,770.7

$ 1,008.4

$ —

Marketable securities:

Corporate equity securities

11.9

11.9

—

—

16.6

16.6

—

—

U.S. Treasury securities

1,660.4

1,660.4

—

—

1,864.9

1,864.9

—

—

U.S. government agency securities

190.8

—

190.8

—

262.4

—

262.4

—

Asset-backed securities

1,233.5

—

1,233.5

—

1,357.0

—

1,357.0

—

Certificates of deposit

18.9

—

18.9

—

26.2

—

26.2

—

Corporate debt securities

4,317.8

—

4,317.8

—

3,693.9

—

3,693.9

—

Commercial paper

64.7

—

64.7

—

14.6

—

14.6

—

Prepaid expenses and other current assets:

Foreign currency forward contracts

60.8

—

60.8

—

6.2

—

6.2

—

Other assets:

Foreign currency forward contracts

39.9

—

39.9

—

12.7

—

12.7

—

Total financial assets

$ 10,255.6

$ 3,023.8

$ 7,231.8

$ —

$ 10,033.6

$ 3,652.2

$ 6,381.4

$ —

Financial instruments carried at fair value (liability positions):

Other current liabilities:

Foreign currency forward contracts

$ ( 35.2 )

$ —

$ ( 35.2 )

$ —

$ ( 79.4 )

$ —

$ ( 79.4 )

$ —

Other long-term liabilities:

Foreign currency forward contracts

( 17.4 )

—

( 17.4 )

—

( 51.0 )

—

( 51.0 )

—

Contingent consideration

( 79.6 )

—

—

( 79.6 )

( 79.0 )

—

—

( 79.0 )

Total financial liabilities

$ ( 132.2 )

$ —

$ ( 52.6 )

$ ( 79.6 )

$ ( 209.4 )

$ —

$ ( 130.4 )

$ ( 79.0 )

Please refer to Note E, “Marketable Securities and Other Investments,” for the carrying amount and related unrealized
gains (losses) by type of investment. Our cash equivalents primarily include money market funds, commercial paper, and
time deposits.
Fair Value of Corporate Equity Securities
We classify our investments in publicly traded corporate equity securities as “ Marketable securities ” on our condensed
consolidated balance sheets. Generally, our investments in the common stock of publicly traded companies are valued based
on Level 1 inputs because they have readily determinable fair values.
Please refer to Note E, “Marketable Securities and Other Investments,” for further information on these investments.
Fair Value of Contingent Consideration
Our Level 3 contingent consideration liabilities of $ 79.6 million are related to $ 678.3 million of development and
regulatory milestones potentially payable to former equity holders of a privately-held company we acquired in 2019. We base
our estimates of the probability of achieving the milestones relevant to the fair value of contingent payments on industry data
attributable to gene therapies and our knowledge of the progress and viability of the associated Duchenne muscular dystrophy
programs. The discount rates used in the valuation model for contingent payments, which were between 4.6 % and 4.7 % as of
June 30, 2026 , represent a measure of credit risk and market risk associated with settling the liabilities. Significant judgment
is used in determining the appropriateness of these assumptions at each reporting period.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

The following table represents a rollforward of the fair value of our contingent consideration liabilities:

Six Months Ended
June 30, 2026

(in millions)

Balance at December 31, 2025

$ 79.0

Increase in fair value of contingent payments

0.6

Balance at June 30, 2026

$ 79.6

E. Marketable Securities and Other Investments
A summary of our cash equivalents and marketable debt and equity securities, which are recorded at fair value, is shown
below:

As of June 30, 2026

As of December 31, 2025

Amortized
Cost

Gross
Unrealized
Gains

Gross
Unrealized
Losses

Fair
Value

Amortized
Cost

Gross
Unrealized
Gains

Gross
Unrealized
Losses

Fair
Value

(in millions)

Cash equivalents

$ 2,656.9

$ —

$ —

$ 2,656.9

$ 2,779.1

$ —

$ —

$ 2,779.1

Marketable securities:

U.S. Treasury securities

1,668.0

0.4

( 8.0 )

1,660.4

1,852.9

12.1

( 0.1 )

1,864.9

U.S. government agency securities

191.0

0.2

( 0.4 )

190.8

261.2

1.2

—

262.4

Asset-backed securities

1,236.1

1.2

( 3.8 )

1,233.5

1,351.1

6.0

( 0.1 )

1,357.0

Certificates of deposit

18.9

—

—

18.9

26.2

—

—

26.2

Corporate debt securities

4,326.1

5.7

( 14.0 )

4,317.8

3,669.3

25.0

( 0.4 )

3,693.9

Commercial paper

64.7

—

—

64.7

14.6

—

—

14.6

Total marketable available-for-
sale debt securities

7,504.8

7.5

( 26.2 )

7,486.1

7,175.3

44.3

( 0.6 )

7,219.0

Corporate equity securities

25.0

—

( 13.1 )

11.9

25.0

—

( 8.4 )

16.6

Total marketable securities

7,529.8

7.5

( 39.3 )

7,498.0

7,200.3

44.3

( 9.0 )

7,235.6

Total cash equivalents and
marketable securities

$ 10,186.7

$ 7.5

$ ( 39.3 )

$ 10,154.9

$ 9,979.4

$ 44.3

$ ( 9.0 )

$ 10,014.7

Amounts in the table above at fair value were classified on our condensed consolidated balance sheets as follows:

As of June 30, 2026

As of December 31, 2025

(in millions)

Cash and cash equivalents

$ 2,656.9

$ 2,779.1

Marketable securities

1,708.9

1,523.3

Long-term marketable securities

5,789.1

5,712.3

Total

$ 10,154.9

$ 10,014.7

Marketable available-for-sale debt securities by contractual maturity were as follows:

As of June 30, 2026

As of December 31, 2025

(in millions)

Matures within one year

$ 1,697.0

$ 1,506.7

Matures after one year through five years

5,689.5

5,595.8

Matures after five years

99.6

116.5

Total

$ 7,486.1

$ 7,219.0

We did no t record any allowances for credit losses to adjust the fair value of our marketable available-for-sale debt
securities during the three and six months ended June 30, 2026 and 2025 . Additionally, we did no t record any realized gains
or losses related to these investments that were material to our condensed consolidated statements of income during the three
and six months ended June 30, 2026 and 2025 . As of June 30, 2026 , we held marketable available-for-sale debt securities
with a total fair value of $ 4.8 billion that were in unrealized loss positions totaling $ 26.2 million , including an insignificant
amount that had been in unrealized loss positions for greater than twelve months.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

We record changes in the fair value of our investments in corporate equity securities to “Other income (expense) , net” in
our condensed consolidated statements of income . During the three and six months ended June 30, 2026 and 2025 , our net
unrealized (losses) gains on corporate equity securities with readily determinable fair values held at the conclusion of each
period were as follows:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

Net unrealized (losses) gains

$ ( 8.5 )

$ 6.4

$ ( 4.7 )

$ ( 8.6 )

As of June 30, 2026 and December 31, 2025 , the carrying value of our equity investments without readily determinable
fair values, which are recorded in “ Other assets ” on our condensed consolidated balance sheets was $ 80.1 million and
$ 81.5  million , respectively.
During the three and six months ended June 30, 2026 , we r e cei ved $ 75.5  million cash proceeds following the conversion
of a note receivable we held from a privately-held company that was acquired. As a result, we recognized a realized gain of
$ 48.7  million within “Other income (expense) , net” in our condensed consolidated statements of income .

F. Accumulated Other Comprehensive Income (Loss)
The following table summarizes the changes in accumulated o th er comprehensive income (loss) (“AOCI”) by
component:

Unrealized Holding Gains
(Losses), Net of Tax

Foreign
Currency
Translation
Adjustment

On Available-
For-Sale Debt
Securities

On Foreign
Currency
Forward
Contracts

Total

(in millions)

Balance at December 31, 2025

$ 37.2

$ 34.0

$ ( 87.1 )

$ ( 15.9 )

Other comprehensive (loss) income before
reclassifications

( 11.6 )

( 49.1 )

96.7

36.0

Amounts reclassified from accumulated other
comprehensive income (loss)

—

0.5

27.9

28.4

Net current period other comprehensive (loss) income

( 11.6 )

( 48.6 )

124.6

64.4

Balance at June 30, 2026

$ 25.6

$ ( 14.6 )

$ 37.5

$ 48.5

Balance at December 31, 2024

$ 9.7

$ 7.1

$ 111.0

$ 127.8

Other comprehensive income (loss) before
reclassifications

29.4

26.3

( 280.0 )

( 224.3 )

Amounts reclassified from accumulated other
comprehensive income (loss)

—

( 2.4 )

( 2.2 )

( 4.6 )

Net current period other comprehensive income (loss)

29.4

23.9

( 282.2 )

( 228.9 )

Balance at June 30, 2025

$ 39.1

$ 31.0

$ ( 171.2 )

$ ( 101.1 )

G. Hedging
Foreign currency forward contracts - Designated as hedging instruments
We maintain a hedging program intended to mitigate the effect of changes in foreign exchange rates for a portion of our
forecasted product revenues denominated in certain foreign currencies. The program includes foreign currency forward
contracts that are designated as cash flow hedges under U.S. GAAP having contractual durations from one to 36 months . We
recognize realized gains and losses for the effective portion of such contracts in “ Product revenues, net ” in our condensed
consolidated statements of income in the same period that we recognize the product revenues that were impacted by the
hedged foreign exchange rate changes.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

We formally document the relationship between foreign currency forward contracts (hedging instruments) and forecasted
product revenues (hedged items), as well as our risk management objective and strategy for undertaking various hedging
activities, which includes matching all foreign currency forward contracts that are designated as cash flow hedges to
forecasted transactions. Using regression analysis, we assess, both at the hedge’s inception and on an ongoing basis, whether
the foreign currency forward contracts are highly effective in offsetting changes in cash flows of hedged items on a
prospective and retrospective basis. As of June 30, 2026 , all hedges were determined to be highly effective.
We consider the impact of our counterparties’ credit risk on the fair value of the foreign currency forward contracts. As
of  June 30, 2026  and  December 31, 2025 , credit risk did not change the fair value of our foreign currency forward contracts.
The following table summarizes the notional amount in U.S. dollars of our outstanding foreign currency forward
contracts designated as cash flow hedges under U.S. GAAP:

As of June 30, 2026

As of December 31, 2025

Foreign Currency

(in millions)

Euro

$ 3,520.1

$ 4,677.9

Canadian dollar

371.7

516.1

British pound sterling

351.6

492.6

Australian dollar

278.0

267.5

Swiss franc

91.2

126.0

Total foreign currency forward contracts

$ 4,612.6

$ 6,080.1

Foreign currency forward contracts - Not designated as hedging instruments
We enter into foreign currency forward contracts, typically with contractual maturities of approximately one month ,
which are designed to mitigate the effect of changes in foreign exchange rates on monetary assets and liabilities, including
intercompany balances. These contracts are not designated as hedging instruments under U.S. GAAP. We recognize realized
gains and losses for such contracts in “Other income (expense) , net” in our condensed consolidated statements of income
each period. As of  June 30, 2026 and December 31, 2025 , the notional amount of our outstanding foreign currency forward
contracts where hedge accounting under U.S. GAAP was not applied was $ 670.9 million and $ 612.6 million , respectively.
During the three and six months ended June 30, 2026 and 2025 , we recognized the following related to foreign currency
forward contracts in our condensed consolidated statements of income :

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

Designated as hedging instruments - Reclassified from AOCI

Product revenues, net

$ ( 10.2 )

$ ( 21.3 )

$ ( 35.7 )

$ 2.8

Not designated as hedging instruments

Other income (expense) , net

$ ( 13.4 )

$ ( 3.1 )

$ ( 16.3 )

$ ( 4.3 )

Total reported in the Condensed Consolidated Statements of Income

Product revenues, net

$ 3,333.9

$ 2,944.0

$ 6,320.8

$ 5,704.2

Other income (expense) , net

$ 24.3

$ 13.2

$ 24.3

$ ( 4.4 )

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

The following table summarizes the fair value of our outstanding foreign currency forward contracts designated as cash
flow hedges under U.S. GAAP included on our condensed consolidated balance sheets:

As of June 30, 2026

Assets

Liabilities

Classification

Fair Value

Classification

Fair Value

(in millions)

Prepaid expenses and other current assets

$ 60.8

Other current liabilities

$ ( 35.2 )

Other assets

39.9

Other long-term liabilities

( 17.4 )

Total assets

$ 100.7

Total liabilities

$ ( 52.6 )

As of December 31, 2025

Assets

Liabilities

Classification

Fair Value

Classification

Fair Value

(in millions)

Prepaid expenses and other current assets

$ 6.2

Other current liabilities

$ ( 79.4 )

Other assets

12.7

Other long-term liabilities

( 51.0 )

Total assets

$ 18.9

Total liabilities

$ ( 130.4 )

As of June 30, 2026 , we expect the amounts that are related to foreign currency forward contracts designated as cash
flow hedges under U.S. GAAP recorded in “ Prepaid expenses and other current assets ” and “ Other current liabilities ” to be
reclassified to earnings within twelve months.
We present the fair value of our foreign currency forward contracts on a gross basis within our condensed consolidated
balance sheets. The following table summarizes the potential effect of offsetting derivatives by type of financial instrument
designated as cash flow hedges under U.S. GAAP on our condensed consolidated balance sheets:

As of June 30, 2026

Gross
Amounts
Recognized

Gross
Amounts
Offset

Gross
Amounts
Presented

Gross
Amounts
Not Offset

Legal Offset

Foreign currency forward contracts

(in millions)

Total assets

$ 100.7

$ —

$ 100.7

$ ( 52.6 )

$ 48.1

Total liabilities

( 52.6 )

—

( 52.6 )

52.6

—

As of December 31, 2025

Gross
Amounts
Recognized

Gross
Amounts
Offset

Gross
Amounts
Presented

Gross
Amounts
Not Offset

Legal Offset

Foreign currency forward contracts

(in millions)

Total assets

$ 18.9

$ —

$ 18.9

$ ( 18.9 )

$ —

Total liabilities

( 130.4 )

—

( 130.4 )

18.9

( 111.5 )

H. Inventories
“Inventories” consisted of the following:

As of June 30, 2026

As of December 31, 2025

(in millions)

Raw materials

$ 233.0

$ 259.8

Work-in-process

1,253.9

1,196.9

Finished goods

278.2

230.1

Total

$ 1,765.1

$ 1,686.8

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

I. Intangible Assets
“Other intangible assets, net” consisted of the following:

As of June 30, 2026

As of December 31, 2025

Estimated
Useful Lives

Gross
Carrying
Amount

Accumulated
Amortization

Net
Carrying
Amount

Gross
Carrying
Amount

Accumulated
Amortization

Net
Carrying
Amount

(in millions, except useful lives)

In-process research and
development

Indefinite

$ 224.6

$ —

$ 224.6

$ 224.6

$ —

$ 224.6

Finite-lived intangible assets -
marketed products

10 to 12 years

238.0

( 52.2 )

185.8

238.0

( 42.1 )

195.9

Finite-lived intangible assets -
assembled workforce

3 years

7.7

( 5.3 )

2.4

7.7

( 4.0 )

3.7

Total other intangible assets,
net

$ 470.3

$ ( 57.5 )

$ 412.8

$ 470.3

$ ( 46.1 )

$ 424.2

In March 2025, based on results from a Phase 1/2 clinical trial evaluating our VX-264 clinical program in patients with
type 1 diabetes (“T1D”), we concluded that VX-264 will not be advancing further in clinical development. Based on this
event, we performed an interim impairment test on the fair value of our VX-264 indefinite-lived in-process research and
development asset that we acquired from Semma Therapeutics, Inc. in 2019. As a result, using the multi period earnings
method of the income approach, we recorded a full intangible asset impairment charge of $ 379.0 million in the first quarter of
2025. As of June 30, 2026 , our remaining indefinite-lived in-process research and development assets were associated with
our T1D program.

J. Stock-based Compensation Expense and Share Repurchase Programs
Stock-based compensation expense
During the three and six months ended June 30, 2026 and 2025 , we recognized the following s tock-based compensation
expense:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

Stock-based compensation expense by type of award:

Restricted stock units (including PSUs)

$ 165.9

$ 162.9

$ 332.4

$ 326.3

ESPP share issuances

5.8

7.1

9.2

12.7

Stock options

2.2

1.2

2.2

1.2

Stock-based compensation expense related to inventories

( 3.7 )

( 3.9 )

( 7.2 )

( 6.8 )

Total stock-based compensation expense included in “Total costs and
expenses”

$ 170.2

$ 167.3

$ 336.6

$ 333.4

Stock-based compensation expense by line item:

Cost of sales

$ 3.8

$ 2.5

$ 7.0

$ 5.1

Research and development expenses

104.4

99.6

206.1

199.7

Selling, general and administrative expenses

62.0

65.2

123.5

128.6

Total stock-based compensation expense included in “Total costs and
expenses”

170.2

167.3

336.6

333.4

Income tax effect

( 35.3 )

( 36.5 )

( 70.6 )

( 111.7 )

Total stock-based compensation expense, net of tax

$ 134.9

$ 130.8

$ 266.0

$ 221.7

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

Share repurchase program
In February 2023, our Board of Directors authorized a share repurchase program (the “2023 Share Repurchase
Program”), pursuant to which we were authorized to repurchase up to $ 3.0  billion of our common stock. As of September 30,
2025, we had repurchased the full amount authorized under the 2023 Share Repurchase Program.
In May 2025, our Board of Directors authorized an additional share repurchase program (the “2025 Share Repurchase
Program”), pursuant to which we are authorized to repurchase up to $ 4.0  billion of our common stock. The 2025 Share
Repurchase Program does not have an expiration date and can be discontinued at any time. As of June 30, 2026 , we had $ 2.6
billion remaining available under the 2025 Share Repurchase Program .
During each of the six months ended June 30, 2026 and 2025 , we repurchased  1.8 million shares of our common stock
under our share repurchase programs, for aggregate repurchas es of $ 799.5 million and $ 811.4 million , respectively.

K. Income Taxes
We are subject to U.S. federal, state, and foreign income taxes. During the three and six months ended June 30, 2026 and
2025 , we recorded the following provisions for income taxes and effective tax rates as compared to our income before
provision for income taxes.

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions, except percentages)

Income before provision for income taxes

$ 1,391.8

$ 1,283.0

$ 2,644.7

$ 2,013.4

Provision for income taxes

$ 292.0

$ 250.1

$ 513.5

$ 334.2

Effective tax rate

21.0 %

19.5 %

19.4 %

16.6 %

Our effective tax rates were equal to the U.S. statutory rate for the three months ended June 30, 2026 , and lower than the
U.S. statutory rate for the six months ended June 30, 2026 , primarily due to excess tax benefits related to stock-based
compensation .
Our effective tax rate for the three and six months ended June 30, 2025 was lower than the U.S. statutory rate primarily
due to excess tax benefits related to stock-based compensation and tax credits.
We have reviewed the tax positions taken, or to be taken, in our tax returns for all tax years currently open to
examination by a taxing authority. As of June 30, 2026 and December 31, 2025 , we had $ 439.4 million and $ 436.6 million ,
respectively, of net unrecognized tax benefits, which would affect our tax rate if recognized.
We file U.S. federal income tax returns and income tax returns in various state, local and foreign jurisdictions. We have
various income tax audits ongoing at any time throughout the world. Except for jurisdictions where we have net operating
losses or tax credit carryforwards, we are no longer subject to any tax assessment from tax authorities for years prior to 2014
in jurisdictions that have a material impact on our consolidated financial statements. Due to the nature of the adjustments
from a settlement with the United Kingdom’s HM Revenue & Customs in 2023, we have asserted our rights under the U.S./
U.K. Income Tax Convention pursuant to the mutual agreement procedures for the relief of double taxation for these matters.
In December 2022, European Union member states reached an agreement to implement the minimum tax component
(“Pillar Two”) of the Organization for Economic Co-operation and Development’s (the “OECD’s”), global international tax
reform initiative with effective dates of January 1, 2024 and 2025. On January 5, 2026, the OECD announced that a ‘side-by-
side’ agreement was reached with member countries creating safe harbors to exempt U.S. multi-nationals from certain taxes
under the Pillar Two regime by recognizing the U.S. tax system as a compatible domestic minimum tax regime. Our exposure
to other countries’ minimum tax regimes was limited before these changes, but the side-by-side agreement allows for
certainty as our structure may change in the future.
In July 2025, the U.S. enacted H.R.1, which includes significant provisions modifying the U.S. tax framework, including
the ability for companies to immediately deduct research and development expenditures for 2025 and provisions for
deducting previously capitalized amounts. H.R.1 does not have a material impact on our U.S. taxes for the f irst half of 2026,
but we expect further guidance to be issued. We will review guidance when issued for impacts on future years and disclose
any impacts if needed at that time. These legislative changes could have an impact on our future effective tax rates, tax
liabilities, and cash taxes.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

L. Commitments and Contingencies
2 0 26 Revolving Credit Agreement
In July 2026, Vertex and certain of its subsidiaries entered into a $ 500.0 million senior unsecured revolving facility (the
“2026 Revolver”) with the lenders and issuing banks party thereto and Bank of America, N.A., as administrative agent, which
matures on July 30, 2031. We have not drawn upon the 2026 Revolver to date. Amounts drawn pursuant to the 2026
Revolver, if any, will be used for general corporate purposes. Subject to satisfaction of certain conditions, we may request
that the borrowing capacity for the 2026 Revolver be increased by an additional $ 500.0 million . Up to $ 100.0 million of the
2026 Revolver may be allocated for loans and letters of credit in certain non-U.S. Dollar currencies. Additionally, the 2026
Revolver provides a sublimit of $ 100.0 million for letters of credit.
Any U.S. Dollar-denominated amounts borrowed under the 2026 Revolver will bear interest, at our option, at a rate per
annum equal to either a base rate or a Secured Overnight Financing Rate (“SOFR”), in each case, plus an applicable margin.
Under the 2026 Revolver, the applicable margins on base rate loans range from 0.000 % to 0.500 % and the applicable margins
on SOFR-based loans range from 0.875 % to 1.500 % , in each case, depending upon, either (x) our consolidated leverage ratio
(the ratio of our total consolidated funded indebtedness to our consolidated EBITDA for the most recently completed four
fiscal quarter period) or (y) to the extent available, our credit rating. Any amounts borrowed in non-U.S. Dollar currencies
will bear interest at a rate per annum equal to the applicable benchmark rate for such currency plus the applicable margin.
Loans made under the 2026 Revolver may be prepaid and commitments under the 2026 Revolver may be reduced at any
time, in whole or in part, without premium or penalty.
Loans made under the 2026 Revolver will be guaranteed by certain of our existing and future domestic subsidiaries,
subject to certain customary exceptions and limitations.
The 2026 Revolver contains customary representations and warranties and affirmative and negative covenants, which
include limitations on subsidiary debt, liens and fundamental changes, as well as a financial covenant to maintain a
consolidated leverage ratio of 3.50 to 1.00 , subject to an increase, at our election, to 4.00 to 1.00 for each of the four fiscal
quarters following a material acquisition.
The 2026 Revolver also contains customary events of default. In the case of a continuing event of default, the
administrative agent would be entitled to exercise various remedies, including the acceleration of amounts due under any
outstanding loans.
Direct costs related to the 2026 Revolver are recorded over its term and are not material to our financial statements.
Prior Credit Facility
In July 2026, in conjunction with entering into the 2026 Revolver, we terminated the $ 500.0  million revolving credit
agreement we entered into in 2022. As of June 30, 2026 , we were in compliance with all covenants associated with this
revolving credit agreement.
2026 Term Loan
In July 2026, we entered into the 2026 Term Loan, as defined and described in Note O, “Subsequent Events.”
Guaranties and Indemnifications
As permitted under Massachusetts law, our Articles of Organization and By-laws provide that we will indemnify certain
of our officers and directors for certain claims asserted against them in connection with their service as an officer or director.
The maximum potential amount of future payments that we could be required to make under these indemnification provisions
is unlimited. However, we have purchased directors’ and officers’ liability insurance policies that could reduce our monetary
exposure and enable us to recover a portion of any future amounts paid. No indemnification claims currently are outstanding,
and we believe the estimated fair value of these indemnification arrangements is minimal.
We customarily agree in the ordinary course of our business to indemnification provisions in agreements with clinical
trial investigators and sites in our product development programs, sponsored research agreements with academic and not-for-
profit institutions, various comparable agreements involving parties performing services for us, and our real estate leases. We
also customarily agree to certain indemnification provisions in our drug discovery, development and commercialization
collaboration agreements. With respect to our clinical trials and sponsored research agreements, these indemnification
provisions typically apply to any claim asserted against the investigator or the investigator’s institution relating to personal
injury or property damage, violations of law or certain breaches of our contractual obligations arising out of the research or

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

clinical testing of our compounds or product candidates. With respect to lease agreements, the indemnification provisions
typically apply to claims asserted against the landlord relating to personal injury or property damage caused by us, to
violations of law by us or to certain breaches of our contractual obligations. The indemnification provisions appearing in our
collaboration agreements are similar to those for the other agreements discussed above, but in addition provide some limited
indemnification for our collaborator in the event of third-party claims alleging infringement of intellectual property rights. In
each of the cases above, the indemnification obligation generally survives the termination of the agreement for some
extended period, although we believe the obligation typically has the most relevance during the contract term and for a short
period of time thereafter. The maximum potential amount of future payments that we could be required to make under these
provisions is generally unlimited. We have purchased insurance policies covering personal injury, property damage and
general liability that reduce our exposure for indemnification and would enable us in many cases to recover all or a portion of
any future amounts paid. We have never paid any material amounts to defend lawsuits or settle claims related to these
indemnification provisions. Accordingly, we believe the estimated fair value of these indemnification arrangements is
minimal.
Legal Matters and Other Contingencie s
As described in Note B, “Collaboration, License and Other Arrangements,” we have an agreement with the CFF (the
“CFF Agreement”) pursuant to which we owe third-party royalties payable on net sales of certain CF products, including
ALYFTREK. Since inception, our ALYFTREK net product revenues total $ 1.8 billion . Based on the CFF Agreement, our
position is that the royalty burden associated with ALYFTREK is 4 % . On October 10, 2025, Royalty Pharma plc (“RP”), the
third party to whom the CFF assigned its rights (and the CFF, which remains a party to the CFF Agreement), initiated a
confidential arbitration alleging the royalty burden on ALYFTREK is approximately 8 % . RP is seeking a declaratory
judgment regarding the royalty burden on ALYFTREK as well as alleged unpaid royalties and other alleged damages
available under the CFF Agreement or applicable law, costs, expenses, attorneys’ fees, and interest. We believe RP’s position
is contrary to the plain terms of the CFF Agreement and intend to vigorously defend our position under the CFF Agreement.
On a quarterly basis, we evaluate developments with claims, whether asserted or unasserted, and legal proceedings that
could result in a loss contingency accrual, or an increase or decrease to a previously accrued loss contingency. There were no
material loss contingencies accrued as of June 30, 2026 or December 31, 2025 .
We also have certain contingent liabilities that arise in the ordinary course of our business activities. We accrue for such
contingent liabilities when it is probable that future expenditures will be made and such expenditures can be reasonably
estimated. Other than our contingent consideration liabilities discussed in Note D, “Fair Value Measurements,” there were no
significant contingent liabilities accrued as of June 30, 2026 or December 31, 2025 .

M. Segment Information
Revenues by Product
“ Product revenues, net ” consisted of the following:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

TRIKAFTA/KAFTRIO

$ 2,497.2

$ 2,551.1

$ 4,851.9

$ 5,086.6

ALYFTREK

573.6

156.8

998.0

210.7

Other CF product revenues (1)

137.1

193.7

273.0

349.0

Total CF product revenues, net

3,207.9

2,901.6

6,122.9

5,646.3

CASGEVY

76.4

30.4

119.3

44.6

JOURNAVX

49.6

12.0

78.6

13.3

Total product revenues, net

$ 3,333.9

$ 2,944.0

$ 6,320.8

$ 5,704.2

(1) Include KALYDECO, ORKAMBI, and SYMDEKO/SYMKEVI.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

Revenues by Geographic Location
“ Product revenues, net ” are allocated based on the location of the customer. “ Other revenues ” are allocated based on the
location of the Vertex entity associated with such revenues. Our “ Total revenues ” consisted of the following:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

United States

$ 2,056.4

$ 1,848.2

$ 3,832.3

$ 3,511.7

Outside of the United States

Europe

977.7

910.9

1,927.7

1,737.5

Other

299.8

205.6

560.8

485.7

Total revenues outside of the United States

1,277.5

1,116.5

2,488.5

2,223.2

Total revenues

$ 3,333.9

$ 2,964.7

$ 6,320.8

$ 5,734.9

We did no t have any “ Other revenues ” in the three and six months ended June 30, 2026 . In the three and six months
ended June 30, 2025 , our “ Other revenues ” of $ 20.7 million and $ 30.7 million , respectively, were attributed to the U.S.
Significant Segment Expenses
Significant segment expenses are set forth in the following table:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

2026

2025

(in millions)

Total revenues

$ 3,333.9

$ 2,964.7

$ 6,320.8

$ 5,734.9

Costs and expenses:

Cost of sales - products

218.3

140.5

378.5

271.1

Cost of sales - royalty

270.9

267.0

503.5

499.4

Research expenses

207.3

209.3

412.3

415.4

Development expenses

786.5

769.1

1,543.1

1,542.7

Acquired in-process research and development expenses

21.4

2.2

21.9

22.0

Selling and other commercial expenses

388.1

264.6

701.7

505.7

General and administrative expenses

194.1

160.0

374.2

315.3

Intangible asset impairment charge

—

—

—

379.0

Interest income, net

( 120.6 )

( 118.7 )

( 235.4 )

( 236.6 )

Other segment items (1)

( 23.9 )

( 12.3 )

( 23.7 )

7.5

Provision for income taxes

292.0

250.1

513.5

334.2

Net income

$ 1,099.8

$ 1,032.9

$ 2,131.2

$ 1,679.2

(1) Other segment items included in “ Net income ” primarily include a realized gain related to an investment in a
privately held company in the three and six months ended June 30, 2026 , changes in the fair value of equity
investments and changes in the fair value of contingent consideration.
Additional Segment Information
During the three and six months ended June 30, 2026 and 2025 , we recorded total depreciation and amortization expense
of $ 56.5 million , $ 51.7 million , and $ 112.4 million and $ 100.1 million , respectively.

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

N. Additional Balance Sheet & Cash Flow Information
Contract Liabilities
We had contract liabilities of $ 157.0 million and $ 171.8 million as of June 30, 2026 and December 31, 2025 ,
respectively, primarily related to annual contracts with government-owned and supported customers in international markets
that limit the amount of annual reimbursement we can receive for our CF products. Upon exceeding the annual
reimbursement amount provided by the customer’s contract with us, our CF products are provided free of charge, which is a
material right. These contracts include upfront payments and fees. If we estimate that we will exceed the annual
reimbursement amount under a contract, we defer a portion of the consideration received for shipments made up to the annual
reimbursement limit as a portion of “ Other current liabilities .” Once the reimbursement limit has been reached, we recognize
the deferred amount as revenue when we ship the free products. Our CF product revenue contracts include performance
obligations that are one year or less.
Our contract liabilities at the end of each fiscal year relate to contracts with CF annual reimbursement limits in
international markets in which the annual period associated with the contract is not the same as our fiscal year. In these
markets, we recognize revenues related to performance obligations satisfied in previous years; however, these revenues do
not relate to any performance obligations that were satisfied more than 12 months prior to the beginning of the current year.
Operating Lease Assets and Liabilities
In 2023, we entered into a strategic agreement with Lonza to support the manufacture of T1D cell therapy product
candidates. As part of this agreement, we have partnered with Lonza to build a 130,000 square foot dedicated new facility in
New Hampshire, which will be operated by Lonza (the “ Lonza Facility ”) and is an embedded lease for accounting purposes.
The lease commencement for the Lonza Facility occurred during the first quarter of 2026, upon which we recorded a right-of-
use asset and corresponding lease liability of $ 95.8  million within each of “ Operating lease assets ” and “ Long-term operating
lease liabilities ” on our condensed consolidated balance sheet. In accordance with our policy for embedded leases with
contract manufacturing organizations, we account for the lease component separately from the variable non-lease
components, which we expense as incurred. Payments will continue through the tenth anniversary of the Lonza Facility ’s
regulatory approval for commercial production. The lease will automatically renew for additional one -year periods, unless
either we or Lonza provides written notice of intent to not renew. We utilize the initial period as our lease term.
We obtained $ 148.8 million and $ 5.1 million of right-of-use operating lease assets in exchange for a similar amount of
lease obligations, including the Lonza Facility amounts described above, during the six months ended June 30, 2026 and
2025 , respectively. These represent non-cash operating activities associated with our condensed consolidated statement of
cash flows.
Cash, Cash Equivalents and Restricted Cash Presented in Condensed Consolidated Statements of Cash Flows
T he cash, cash equivalents and restricted cash at the beginning and end of each period presented in our condensed
consolidated statements of cash flows consisted of the following:

Six Months Ended June 30,

2026

2025

Beginning of
period

End of
period

Beginning of
period

End of
period

(in millions)

Cash and cash equivalents

$ 5,084.8

$ 6,143.5

$ 4,569.6

$ 4,972.2

Prepaid expenses and other current assets

3.0

10.6

2.6

9.8

Cash, cash equivalents and restricted cash per condensed
consolidated statement of cash flows

$ 5,087.8

$ 6,154.1

$ 4,572.2

$ 4,982.0

O. Subsequent Events
Crinetics Acquisition
On July 6, 2026, we entered into an agreement and plan of merger to acquire (the “Crinetics Acquisition” ) all of the
issued and outstanding shares of common stock of Crinetics Pharmaceuticals, Inc., a publicly traded biotechnology company
focused on discovering, developing, and commercializing novel therapeutics for endocrine diseases and endocrine-related
tumors, for $ 85.00 per share in cash, f or a total equity value of approximately $ 10.0  billion . The transaction is expected to

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VERTEX PHARMACEUTICALS INCORPORATED
Notes to Condensed Consolidated Financial Statements (unaudited)

close in the third quarter of 2026, subject to certain customary closing conditions . We will account for the acquisition in the
period that it closes. We intend to fund the acquisition using a combination of our cash, cash equivalents, and proceeds from
the 2026 Term Loan , as defined below. The Crinetics Acquisition is not conditioned on our receipt of financing.
Concurrently with entry into the merger agreement for the Crinetics Acquisition, we entered into a debt commitment
letter dated July 6, 2026 with Bank of America, N.A., BofA Securities, Inc. and Morgan Stanley Senior Funding, Inc.,
pursuant to which they agreed to provide us with an unsecured 364 -day bridge loan facility. On July 30, 2026, this
commitment was terminated upon entry into the 2026 Term Loan, described below.
Term Loan Credit Agreement
On July 30, 2026, we entered into a term loan credit agreement (the “2026 Term Loan”) with the lenders and issuing
banks party thereto and Bank of America, N.A., as administrative agent, which provides for a $ 4.5  billion senior unsecured
delayed draw term loan A facility. Amounts borrowed under the 2026 Term Loan will be used to finance a portion of the
Crinetics Acquisition.
Any amounts borrowed under the 2026 Term Loan will become payable in full as follows: (a) a $ 1.0  billion tranche due
364 days after the amounts are borrowed (the “Funding Date”) (“Tranche 1 Loans”), (b) a $ 1.0  billion tranche due on the date
that is two years after the Funding Date (“Tranche 2 Loans”), and (c) a $ 2.5  billion tranche due on the date that is three years
after the Funding Date (“Tranche 3 Loans”). We have not drawn upon the 2026 Term Loan to date.
Loans made under the 2026 Term Loan will bear interest, at our option, at a rate per annum equal to either a base rate or
a SOFR-based rate, in each case, plus an applicable margin. Under the 2026 Term Loan, the applicable margin on base rate
loans ranges from 0.000 % to 0.500 % for Tranche 1 and Tranche 2 Loans and from 0.000 % to 0.625 % for Tranche 3 Loans,
and the applicable margin on SOFR-based loans ranges from 0.8750 % to 1.500 % for Tranche 1 and Tranche 2 Loans and
from 1.000 % to 1.625 % for Tranche 3 Loans, in each case , depending upon, either (x) our consolidated leverage ratio (the
ratio of our total consolidated funded indebtedness to our consolidated EBITDA for the most recently completed four fiscal
quarter period) or (y) to the extent available, our credit rating. Loans made under the 2026 Term Loan may be prepaid and
commitments under the 2026 Term Loan may be reduced at any time, in whole or in part, without premium or penalty. There
are no mandatory prepayments or amortization required in connection with the loans made under the 2026 Term Loan.
Loans made under the 2026 Term Loan will be guaranteed by certain of our existing and future domestic subsidiaries.
The 2026 Term Loan also contains customary representations and warranties and affirmative and negative covenants, in
each case, that are substantially consistent with the representations and warranties and covenants contained in the 2026
Revolver and which include a financial covenant to maintain a consolidated leverage ratio of 3.50 to 1.00, subject to an
increase, at our election, to 4.00 to 1.00 for each of the four fiscal quarters following a material acquisition.
The 2026 Term Loan also contains customary events of default that are substantially consistent with the events of default
contained in the 2026 Revolver. In the case of a continuing event of default, the administrative agent would be entitled to
exercise various remedies, including the acceleration of amounts due under any outstanding loan.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

OVERVIEW
We are a global biotechnology company that invests in scientific innovation to create transformative medicines for
people with serious diseases, with a focus on specialty markets. We have seven approved medicines: five that treat the
underlying cause of cystic fibrosis (“CF”), a life-threatening genetic disease, one that treats severe sickle cell disease
(“SCD”) and transfusion dependent beta thalassemia (“TDT”), life shortening inherited blood disorders, and one that treats
moderate-to-severe acute pain. We are also preparing for the anticipated launch of povetacicept, a potential treatment for IgA
nephropathy (“IgAN”). Our clinical-stage pipeline spans a range of programs targeting CF, SCD, beta thalassemia,
neuropathic pain, type 1 diabetes, IgA nephropathy, primary membranous nephropathy and other autoimmune diseases and
cytopenias, APOL1-mediated kidney disease, autosomal dominant polycystic kidney disease and myotonic dystrophy type 1,
reflecting our commitment to addressing significant unmet medical needs globally.

Financial Highlights

Total Revenues

In the second quarter of 2026 , our total revenues increased to $3.3 billion as compared to $3.0
billion in the second quarter of 2025 , primarily due to continued performance of our CF therapies
and growth from diversification into additional disease areas.

Cost of Sales

Our cost of sales as a percentage of our net product revenues increased to 14.7% in the second
quarter of 2026 as compared to 13.8% in the second quarter of 2025 , as a result of changes in
product mix, partially offset by a lower blended royalty rate for our CF medicines.

Total R&D, AIPR&D
and SG&A Expenses

Our total research and development (“R&D”), acquired in-process research and development
expenses (“AIPR&D”) and selling, general and administrative (“SG&A”) expenses increased to
$1.6 billion in the second quarter of 2026 as compared to $1.4 billion in the second quarter of
2025 , primarily due to increased investment to commercialize our new products .

Cash

Our total cash, cash equivalents and marketable securities increased to $13.6 billion as of June 30,
2026 as compared to $12.3 billion as of December 31, 2025 primarily due to cash flows provided
by our operating activities, partially offset by repurchases of our common stock .

Q2 2025

Q2 2026

December 31, 2025

June 30, 2026

Note: Charts above may not add due to rounding.

Business Updates
Marketed Products
Cystic Fibrosis
We expect that the number of people with CF taking our medicines will continue to grow through new approvals and
reimbursement agreements, treatment of younger patients, increased survival and expansion into additional geographies.
Recent progress in activities expanding our CF business is included below:
• In the second quarter of 2026, we secured reimbursement for ALYFTREK in four additional countries, including
Spain, bringing the total number of countries where ALYFTREK is reimbursed to 25. We also signed a letter of
intent with the Pan-Canadian Pharmaceutical Alliance for reimbursement of ALYFTREK for eligible patients six
years of age and older in Canada.

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Sickle Cell Disease and Beta Thalassemia
• In the second quarter of 2026, we recorded $76.4 million of CASGEVY product revenues, representing a 78%
increase compared to the first quarter of 2026 and a 151% increase compared to the second quarter of 2025 .
• The U.S. Food and Drug Administration (the “FDA”) approved CASGEVY in children two years of age and older
with SCD or TDT, making it the first genetic therapy indicated for children as young as two years of age for both
SCD and TDT. Approximately 5,500 patients with SCD or TDT may be eligible for treatment with CASGEVY for
the first time with this approval. We also completed regulatory submissions in the Kingdom of Saudi Arabia (“Saudi
Arabia”) and the United Kingdom for the treatment of children five to eleven years of age.
• In May, we secured reimbursement for CASGEVY for eligible patients 12 years and older with SCD or TDT in
Germany. We are committed to working with government and reimbursement authorities globally to ensure
sustainable access for eligible patients.
Acute Pain
• In the second quarter of 2026, we recorded $49.6 million of JOURNAVX product revenues, representing a 71%
increase compared to the first quarter of 2026 and a more than 300% increase compared to the second quarter of
2025 .
• In the second quarter and first six months of 2026, approximately 535,000 and 900,000 prescriptions, respectively,
have been filled for JOURNAVX across the hospital and retail settings.
• We have reached agreements with two additional major pharmacy benefit managers for Medicare Part D coverage of
JOURNAVX. As a result, seniors covered by three of the four major Medicare Part D pharmacy benefit managers
have reimbursed access. Twenty-three states provide coverage for JOURNAVX via Medicaid. In total,
approximately 260 million individuals have reimbursed access to JOURNAVX across a wide range of commercial
and government payers.
Pipeline
We continue to advance a diversified pipeline of potentially transformative medicines for serious diseases utilizing a
range of modalities. Recent and anticipated progress in activities supporting these efforts is included below:
Cystic Fibrosis
• Following positive results from the Phase 3 clinical trial evaluating ALYFTREK in children with CF two to five
years of age, we initiated global regulatory submissions for this age group.
Acute and Peripheral Neuropathic Pain
• During the second quarter of 2026, Health Canada accepted our new drug submission for suzetrigine for the
treatment of moderate-to-severe acute pain, and review is underway.
• We expect to complete enrollment in both Phase 3 clinical trials evaluating suzetrigine in diabetic peripheral
neuropathy, a form of peripheral neuropathic pain, by the end of 2026.
IgA Nephropathy and Other B Cell-Mediated Diseases
• We are developing povetacicept, a dual inhibitor of B cell activating factor (“BAFF”) and a proliferation-inducing
ligand (“APRIL”) cytokines, for multiple diseases. Povetacicept represents a potentially best-in-class approach to
control B cell activity in IgAN.
• The FDA accepted our biologics license application for accelerated approval of povetacicept for adults with IgAN
and assigned a PDUFA target action date of November 30, 2026. If approved, povetacicept will become the first
commercialized therapy in our emerging nephrology franchise.
• We have completed our regulatory submission for accelerated approval of povetacicept in adults with IgAN in Saudi
Arabia, and the Saudi Food and Drug Authority has granted Breakthrough Designation to povetacicept.
• Povetacicept represents a potentially best-in-class approach to control B cell activity in primary membranous
nephropathy (“pMN”), another B cell-mediated disease. We completed the Phase 2B portion of the Phase 2/3

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OLYMPUS pivotal trial evaluating povetacicept in people with pMN, and we confirmed the dose selection for the
Phase 3 portion, which is underway.
APOL1-Mediated Kidney Disease
• Inaxaplin is our small molecule for the treatment of APOL1-mediated kidney disease (“AMKD”). We expect to
complete full enrollment in the AMPLITUDE Phase 2/3 pivotal clinical trial evaluating inaxaplin in the second half
of 2026.
• We expect to share data from the interim analysis of the AMPLITUDE clinical trial in early 2027. We expect to
conduct the pre-planned interim analysis for potential U.S. accelerated approval once the interim analysis cohort has
been treated for 48 weeks.
Type 1 Diabetes
• Zimislecel is an allogeneic, stem cell-derived, fully differentiated, insulin-producing islet cell replacement therapy,
using standard immunosuppression to protect the implanted cells. We are enrolling and dosing patients in the Phase
1/2/3 clinical trial of zimislecel in people with type 1 diabetes (“T1D”).
• The FDA cleared the Investigational New Drug Application for VX-017, our stem cell-derived, fully differentiated
islet cell therapy designed to treat all eligible patients with T1D, regardless of blood type. We plan to initiate a Phase
1/2 clinical trial to evaluate the safety and efficacy of VX-017 in people with T1D in the near term.
• We expect to provide updated timelines for the zimislecel and VX-017 programs in 2026.
Investment in External Innovation
• In July, we entered into an agreement and plan of merger (the “Crinetics Merger Agreement”) to acquire all of the
issued and outstanding shares of common stock of Crinetics Pharmaceuticals, Inc. (“Crinetics”) for $85.00 per share
in cash, for a total equity value of approximately $10.0 billion (the “Crinetics Acquisition”). We expect the
transaction to close in the third quarter of 2026, subject to certain customary conditions. Crinetics’ PALSONIFY ®
(paltusotine) is a once-daily oral therapy for adults with acromegaly, a rare and debilitating condition caused by a
pituitary tumor that secretes excess growth hormone, who had an inadequate response to surgery and/or for whom
surgery is not an option. PALSONIFY is approved by the FDA and the European Medicines Agency, and is under
review by other global regulatory bodies. Crinetics’ most advanced pipeline candidate, atumelnant, is a once-daily
oral adrenocorticotropic hormone receptor antagonist in Phase 3 development for congenital adrenal hyperplasia.

Our Business Environment
In the first half of 2026 , our total product revenues came primarily from the sale of our medicines for the treatment of
CF. Our CF strategy involves continuing to develop and obtain approval and reimbursement for treatment regimens that will
provide benefits to all people with CF and increasing the number of people with CF eligible and able to receive our
medicines. Outside of CF, we continue to advance the commercialization of CASGEVY for the treatment of SCD and TDT,
and JOURNAVX for the treatment of acute pain, and we are preparing for a potential launch of povetacicept for the treatment
of IgAN. In addition, we are advancing our pipeline of product candidates for the treatment of serious diseases outside of CF,
SCD, TDT and acute pain.
Our strategy is to combine transformative advances in the understanding of causal human biology and the science of
therapeutics to discover and develop innovative medicines. This approach includes advancing multiple compounds or
therapies from each program, spanning multiple modalities, into early clinical trials to obtain patient data that can inform
selection of the most promising therapies for later-stage development, as well as to inform discovery and development
efforts. We aim to serially innovate in our disease areas of interest and follow our first-in-class therapies with potential best-
in-class candidates to provide durable clinical and commercial success.
In pursuit of new product candidates and therapies in specialty markets, we invest in research and development. We
believe that pursuing research in diverse areas allows us to balance the risks inherent in product development and may
provide product candidates that will form our pipeline in future years. To supplement our internal research programs, we
acquire technologies and programs and collaborate with biopharmaceutical and technology companies, leading academic
research institutions, government laboratories, foundations and other organizations, as needed, to advance research in our
areas of therapeutic interest and to access technologies needed to execute on our strategy.

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Discovery and development of a new pharmaceutical or biological product is a difficult and lengthy process that requires
significant financial resources along with extensive technical and regulatory expertise. Across the industry, most potential
drug or biological products never progress into development, and most products that advance into development never receive
marketing approval. Our investments in product candidates are subject to considerable risks. We closely monitor our research
and development activities, and frequently evaluate our pipeline programs in light of new data and scientific, business and
commercial insights, with the objective of balancing risk and potential. This process can result in rapid changes in focus and
priorities as new information becomes available and as we gain additional understanding of our ongoing programs and
potential new programs, as well as those of our competitors. In addition, our product candidates must satisfy rigorous
standards of safety and efficacy before they can be approved for sale by regulatory authorities. Our analysis of data obtained
from nonclinical and clinical activities is subject to confirmation and interpretation by regulatory authorities, which could
delay, limit or prevent regulatory approval.
Our business also requires ensuring appropriate manufacturing and supply of our products. As we advance our product
candidates through clinical development toward commercialization and market and sell our approved products, we build and
maintain our supply chain and quality assurance resources. We rely on a global network of third parties, including some in
China, and our internal capabilities to manufacture and distribute our products for commercial sale and post-approval clinical
trials and to manufacture and distribute our product candidates for clinical trials. In addition to establishing supply chains for
each newly approved product, we adapt our supply chain for existing products to include additional formulations or to
increase scale of production for existing products as needed. The processes for biological and cell and genetic therapies can
be more complex than those required for small molecule drugs and require additional investments in different systems,
equipment, facilities and expertise. We are focused on ensuring the stability of the supply chains for our current products, as
well as for our pipeline programs.
Sales of our products depend, to a large degree, on the extent to which our products are reimbursed by third-party payors,
such as government health programs, commercial insurance and managed health care organizations. Reimbursement for our
products, including our potential pipeline therapies, cannot be assured and may take significant periods of time to obtain. We
dedicate substantial management and other resources to obtain and maintain appropriate levels of reimbursement for our
products from third-party payors, including governmental organizations in the U.S. and ex-U.S. markets. In the U.S., we
work with government and commercial payors to obtain and maintain appropriate levels of reimbursement for our medicines.
In ex-U.S. markets, we seek government reimbursement for our medicines on a country-by-country or region-by-region, as
required. This is necessary for each new medicine, as well as for label expansions for our current medicines. We expect to
continue to focus significant resources to expand and maintain reimbursement for our CF medicines, CASGEVY,
JOURNAVX, and, ultimately, our pipeline therapies, in U.S. and ex-U.S. markets.

Strategic Transactions
Acquisitions
As part of our business strategy, we seek to license or acquire technologies, products, product candidates and businesses
that are aligned with our corporate and research and development strategies and complement and advance our ongoing
research and development efforts. We have acquired multiple biotechnology companies over the last several years and expect
to continue to identify and evaluate such opportunities. The accounting for an acquisition can vary significantly based on
whether we conclude the relevant transaction represents a business combination or asset acquisition.
In 2024, we acquired Alpine Immune Sciences, Inc. (“Alpine”) and its lead molecule, povetacicept, for approximately
$5.0 billion. Povetacicept, has shown potential to treat multiple diseases or conditions and become a pipeline-in-a-product.
We accounted for the Alpine transaction as an asset acquisition because povetacicept represented substantially all of the fair
value of the gross assets that we acquired. As a result, $4.4 billion of the fair value attributed to povetacicept was expensed as
AIPR&D in 2024.
In July 2026, we entered into the Crinetics Merger Agreement to acquire Crinetics as described above. Crinetics is a
publicly traded biotechnology company focused on discovering, developing, and commercializing novel therapeutics for
endocrine diseases and endocrine-related tumors. We will acquire Crinetics for $85.00 per share in cash, for a total equity
value of approximately $10.0 billion . We expect to fund the acquisition with our cash, cash equivalents, and proceeds from
the 2026 Term Loan, as defined below. The Crinetics Acquisition is not conditioned on our receipt of financing. We will
account for the acquisition in the period that it closes.

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Collaboration and In-Licensing Arrangements
We enter into arrangements with third parties, including collaboration and licensing arrangements, for the development,
manufacture and commercialization of products, product candidates and other technologies that have the potential to
complement our ongoing research and development efforts.
Over the last several years, we entered into collaboration agreements with a number of companies, including CRISPR
Therapeutics AG (“CRISPR”) and Entrada Therapeutics, Inc. (“Entrada”).
Generally, when we in-license a technology or product candidate, we make upfront payments to the collaborator, assume
the costs of the program and/or agree to make contingent payments, which could consist of milestone, royalty and option
payments. Most of these collaboration payments are expensed as AIPR&D because they were primarily attributable to
acquired in-process research and development for which there was no alternative future use. However, depending on many
factors, including the structure of the collaboration, the stage of development of the acquired technology, the significance of
the in-licensed product candidate to the collaborator’s operations and the other activities in which our collaborators are
engaged, the accounting for these transactions can vary significantly. We expect to continue to identify and evaluate
collaboration and licensing opportunities that may be similar to or different from the collaborations and licenses that we have
engaged in previously.
Acquired In-Process Research and Development Expenses
In the first half of 2026 and 2025 , our AIPR&D included $21.9 million and $22.0 million , respectively, related to
upfront, contingent milestone, or other payments pursuant to our business development transactions, including the asset
acquisitions, collaborations, and licenses of third-party technologies described above. Please refer to Note B, “Collaboration,
License and Other Arrangements,” for further information regarding our asset acquisitions, collaborations and in-license
agreements.
Out-licensing Arrangements
We also have out-licensed certain development programs to collaborators who are leading the development or
commercialization of these programs, either globally or within certain geographic regions.
In January 2025 and June 2025, we entered into agreements with Zai Lab Limited (“Zai”) and Ono Pharmaceuticals Co.,
Ltd (“Ono”), respectively, for the development and commercialization of povetacicept in various Asian markets. Zai licensed
povetacicept for mainland China, Hong Kong SAR, Macau SAR, Taiwan region and Singapore, while Ono licensed
povetacicept for Japan and South Korea. Zai and Ono will help advance povetacicept clinical trials, and will be responsible
for obtaining marketing authorizations and commercialization activities, if povetacicept becomes an approved product, in
their licensed territories. We are eligible to receive certain future milestone payments and tiered royalties on future net sales
of povetacicept in these regions.

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RESULTS OF OPERATIONS

Total Revenues

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

TRIKAFTA/KAFTRIO

$ 2,497.2

$ 2,551.1

(2)%

$ 4,851.9

$ 5,086.6

(5)%

ALYFTREK

573.6

156.8

266%

998.0

210.7

374%

Other CF product revenues (1)

137.1

193.7

(29)%

273.0

349.0

(22)%

Total CF product revenues, net

3,207.9

2,901.6

11%

6,122.9

5,646.3

8%

CASGEVY

76.4

30.4

151%

119.3

44.6

167%

JOURNAVX

49.6

12.0

313%

78.6

13.3

491%

Product revenues, net

3,333.9

2,944.0

13%

6,320.8

5,704.2

11%

Other revenues

—

20.7

**

—

30.7

**

Total revenues

$ 3,333.9

$ 2,964.7

12%

$ 6,320.8

$ 5,734.9

10%

(1) Include KALYDECO, ORKAMBI and SYMDEKO/SYMKEVI.

** Not meaningful

Product Revenues, Net
In the second quarter and first half of 2026 , our net product revenues increased 13% and 11% , as compared to the second
quarter and first half of 2025 , respectively, primarily due to continued performance of our CF therapies and growth from
diversification into additional disease areas.
Other Revenues
In the second quarter of 2025 , our other revenues included a $20.6 million upfront payment received from our
collaboration agreement with Ono Pharmaceuticals Co., Ltd. In the first half of 2025 , our other revenues also included a
$10.0 million upfront payment received from our collaboration agreement with Zai Lab Limited.
Total Revenues by Geographic Location
Our total revenues from the U.S. and from ex-U.S. markets were as follows:

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

United States

$ 2,056.4

$ 1,848.2

11%

$ 3,832.3

$ 3,511.7

9%

ex-U.S.

1,277.5

1,116.5

14%

2,488.5

2,223.2

12%

Total revenues

$ 3,333.9

$ 2,964.7

12%

$ 6,320.8

$ 5,734.9

10%

In the second quarter and first half of 2026 , our U.S. total revenues increased 11% and 9% , as compared to the second
quarter and first half of 2025 , respectively, primarily due to continued strong patient demand, including from new initiations
of ALYFTREK, and higher realized net prices in CF, and contributions from CASGEVY and JOURNAVX.
In the second quarter and first half of 2026 , our ex-U.S. total revenues increased 14% and 12% , as compared to the
second quarter and first half of 2025 , respectively, primarily due to strong CF performance across multiple geographies,
including ALYFTREK uptake, increased CASGEVY product revenues, and favorable impacts from foreign exchange.

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Operating Costs and Expenses

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

Cost of sales

$ 489.2

$ 407.5

20%

$ 882.0

$ 770.5

14%

Research and development expenses

993.8

978.4

2%

1,955.4

1,958.1

—%

Acquired in-process research and development
expenses

21.4

2.2

**

21.9

22.0

**

Selling, general and administrative expenses

582.2

424.6

37%

1,075.9

821.0

31%

Intangible asset impairment charge

—

—

**

—

379.0

**

Change in fair value of contingent consideration

0.4

0.9

**

0.6

3.1

**

Total costs and expenses

$ 2,087.0

$ 1,813.6

15%

$ 3,935.8

$ 3,953.7

—%

** Not meaningful

Cost of Sales
Our cost of sales primarily cons ists of third-party royalties payable on net sales of our CF products as well as the cost of
producing inventories. Our cost of sales as a percentage of our net product revenues increased to 14.7% and 14.0% in the
second quarter and first half of 2026 , respectively, as compared to 13.8% and 13.5% in the second quarter and first half of
2025 , respectively, as a result of changes in product mix, partially offset by a lower blended royalty rate for our CF
medicines.
Pursuant to our agreement (the “CFF Agreement”) with the Cystic Fibrosis Foundation (the “CFF”), our tiered third-
party royalties on sales of ALYFTREK, TRIKAFTA/KAFTRIO, SYMDEKO/SYMKEVI, KALYDECO, and ORKAMBI,
calculated as a percentage of net sales, range from the single digits to the sub-teens, with lower royalties on sales of
ALYFTREK and TRIKAFTA/KAFTRIO than for our other products. The royalty burden associated with TRIKAFTA/
KAFTRIO is 9.33%, and our position is that the royalty burden associated with ALYFTREK is 4%. On October 10, 2025,
Royalty Pharma plc (“RP”), the third party to whom the CFF assigned its rights (and the CFF, which remains a party to the
CFF Agreement), initiated a confidential arbitration alleging the royalty burden on ALYFTREK is approximately 8%. RP is
seeking a declaratory judgment regarding the royalty burden on ALYFTREK as well as alleged unpaid royalties and other
alleged damages available under the CFF Agreement or applicable law, costs, expenses, attorneys’ fees, and interest. We
believe RP’s position is contrary to the plain terms of the CFF Agreement and intend to vigorously defend our position under
the CFF Agreement.

Research and Development Expenses

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

Research expenses

$ 207.3

$ 209.3

(1)%

$ 412.3

$ 415.4

(1)%

Development expenses

786.5

769.1

2%

1,543.1

1,542.7

—%

Total research and development expenses

$ 993.8

$ 978.4

2%

$ 1,955.4

$ 1,958.1

—%

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Research Expenses

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

Research Expenses:

Salary and benefits

$ 51.3

$ 53.1

(3)%

$ 106.5

$ 106.2

—%

Stock-based compensation expense

21.2

22.5

(6)%

42.4

44.8

(5)%

Outsourced services and other direct expenses

71.2

71.0

—%

137.8

144.1

(4)%

Infrastructure costs

63.6

62.7

1%

125.6

120.3

4%

Total research expenses

$ 207.3

$ 209.3

(1)%

$ 412.3

$ 415.4

(1)%

Our research expenses include investment in our pipeline, including our cell and genetic therapy capabilities . We expect
to continue to invest in our research programs with a focus on creating transformative medicines for serious diseases.

Development Expenses

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

Development Expenses:

Salary and benefits

$ 194.1

$ 187.3

4%

$ 406.7

$ 383.2

6%

Stock-based compensation expense

83.2

77.1

8%

163.7

154.9

6%

Outsourced services and other direct expenses

367.7

372.5

(1)%

693.9

752.2

(8)%

Infrastructure costs

141.5

132.2

7%

278.8

252.4

10%

Total development expenses

$ 786.5

$ 769.1

2%

$ 1,543.1

$ 1,542.7

—%

As we have advanced our pipeline of transformative medicines, we have invested in internal headcount and infrastructure
to support multiple mid- and late-stage clinical development programs, including our povetacicept, T1D, peripheral
neuropathic pain and AMKD programs. We expect to continue to invest in these programs, launch new products and advance
our pipeline going forward. Our outsourced services and other direct expenses were lower as compared to the first half of
2025 due to the discontinuation of certain clinical programs during 2025.
Our research and development expenses include internal and external costs incurred for research and development of our
products and product candidates. We assign external costs of services provided to us by clinical research organizations and
other outsourced research by individual program. Our internal costs include salary and benefits, stock-based compensation
expense, laboratory supplies and other direct expenses and infrastructure costs, the majority of which are not assigned to
individual products or product candidates. Our stock-based compensation expenses, including those recorded as research and
development expenses, have historically fluctuated and are expected to continue to fluctuate from one period to another
primarily due to changes in the probability of achieving milestones associated with our performance-based awards.

Acquired In-Process Research and Development Expenses

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

Acquired in-process research and development
expenses

$ 21.4

$ 2.2

**

$ 21.9

$ 22.0

**

** Not meaningful

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AIPR&D in the second quarters and first halves of 2026 and 2025 included various upfront and milestone payments
related to our collaboration and in-licensing arrangements . Our AIPR&D has historically fluctuated, and is expected to
continue to fluctuate, from one period to another due to upfront, contingent milestone, and other payments pursuant to our
existing and future business development transactions, including collaborations, licenses of third-party technologies, and
asset acquisitions.

Selling, General and Administrative Expenses

Three Months Ended
June 30,

Six Months Ended
June 30,

2026

2025

Change

2026

2025

Change

(in millions, except percentages)

Selling, general and administrative expenses

$ 582.2

$ 424.6

37%

$ 1,075.9

$ 821.0

31%

In the second quarter and first half of 2026 , our selling, general and administrative expenses increased by 37% and 31%
as compared to the second quarter and first half of 2025 , respectively, primarily due to increased internal headcount and
commercial investment to support JOURNAVX and the anticipated launch of povetacicept in IgAN . We expect to continue to
invest in our commercialization capabilities in support of our current and future product launches.

Intangible Asset Impairment Charge
In the first quarter of 2025 , based on results from a Phase 1/2 clinical trial evaluating our VX-264 clinical program in
patients with T1D, we concluded that VX-264 will not be advancing further in clinical development. Based on this event, we
performed an interim impairment test on the fair value of our VX-264 indefinite-lived in-process research and development
asset. As a result, we recorded a full intangible asset impairment charge of $379.0 million associated with VX-264 in the first
quarter of 2025.

Non-Operating Income (Expense), Net
Interest Income, Net
Our net interest income of $120.6 million and $235.4 million in the second quarter and first half of 2026 , respectively,
was similar to our net interest income of $118.7 million and $236.6 million of net interest income in the second quarter and
first half of 2025 , respectively. Due to our anticipated acquisition of Crinetics in the third quarter of 2026, we expect our
future net interest income to decrease.
Other Income (Expense), Net
Other income (expense), net was income of $24.3 million in the second quarter of 2026 , $13.2 million in the second
quarter of 2025 , and $24.3 million in the first half of 2026 , and net expenses of $4.4 million in the first half of 2025 . Our
other income (expense), net in the second quarter and first half of 2026 was primarily due to a realized gain associated with
one of our strategic investments. Our other income (expense), net in the second quarter and first half of 2025 was primarily
due to net unrealized and realized gains and losses resulting from changes in the fair value of certain of our strategic equity
investments and net foreign currency exchange gains and losses

Income Taxes
Our effective tax rate fluctuates from period to period due to the global nature of our operations. The factors that most
significantly impact our effective tax rate include changes in tax laws, excess tax benefits related to stock-based
compensation, variability in the amount and allocation of our taxable earnings among multiple jurisdictions, the amount and
characterization of our research and development expenses, the levels of certain deductions and credits, adjustments to the
value of our uncertain tax positions, acquisitions and third-party collaboration and licensing transactions.
In July 2025, the U.S. enacted H.R.1, which includes significant provisions modifying the U.S. tax framework, including
the ability for companies to immediately deduct research and development expenditures for 2025 and provisions for
deducting previously capitalized amounts. H.R.1 does not have a material impact on our U.S. taxes for the first half of 2026,
but we expect further guidance to be issued. We will review guidance when issued for impacts on future years and disclose
any impacts if needed at that time. These legislative changes could have an impact on our future effective tax rates, tax
liabilities, and cash taxes.
Our effective tax rate of 19.4% in the first half of 2026 was lower than the U.S. statutory rate , primarily due to excess tax

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benefits related to stock-based compensation. Our effective tax rate of 16.6% in the first half of 2025 was lower than the U.S.
statutory rate, primarily due to excess tax benefits related to stock-based compensation and tax credits.

LIQUIDITY AND CAPITAL RESOURCES
The following table summarizes the components of our financial condition as of June 30, 2026 and December 31, 2025 :

As of June 30, 2026

As of December 31, 2025

Change

(in millions, except percentages)

Cash, cash equivalents and marketable securities:

Cash and cash equivalents

$ 6,143.5

$ 5,084.8

Marketable securities

1,708.9

1,523.3

Long-term marketable securities

5,789.1

5,712.3

Total cash, cash equivalents and marketable
securities

$ 13,641.5

$ 12,320.4

11%

Working Capital:

Total current assets

$ 12,543.7

$ 11,201.0

12%

Total current liabilities

(3,937.9)

(3,861.2)

2%

Total working capital

$ 8,605.8

$ 7,339.8

17%

Working Capital
As of June 30, 2026 , total working capital was $8.6 billion , which represented an increase of $1.3 billion , or 17% ,
compared to December 31, 2025 , primarily due to increased cash, cash equivalents and marketable securities resulting from
the continued performance of our CF therap ies .
Cash Flows

Six Months Ended June 30,

2026

2025

(in millions)

Net cash provided by (used in):

Operating activities

$ 2,553.5

$ 1,892.0

Investing activities

$ (477.7)

$ (540.3)

Financing activities

$ (965.5)

$ (1,029.6)

Operating Activities
Cash provided by operating activities increased to $2.6 billion in the first half of 2026 , as compared to $1.9 billion in the
first half of 2025 , prim arily due to incr eased net product revenues, the timing of income tax payments, and reduced purchases
of inventory.
Investing Activities
Cash used in investing activities of $477.7 million and $540.3 million in the first half of 2026 and 2025 , respectively,
were primarily related to net purchases of available-for-sale debt securities and property and equipment.
Financing Activities
Cash used in financing activities of $965.5 million and $1.0 billion in the first half of 2026 and 2025 , respectively, were
primarily related to repurchases of our common stock pursuant to our share repurchase programs and payments in connection
with common stock withheld for employee tax obligations.

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Sources and Uses of Liquidity
We intend to rely on our existing cash, cash equivalents and current marketable securities together with our operating
profitability as our primary source of liquidity. We expect that cash flows from our product sales together with our cash, cash
equivalents and current marketable securities will be sufficient to fund our operations for at least the next twelve months. In
July 2026, we entered into the Crinetics Merger Agreement to acquire Crinetics for $85.00 per share in cash, for a total equity
value of approximately $10.0 billion, which we will fund with our cash, cash equivalents, and proceeds from the 2026 Term
Loan, as defined below.
The adequacy of our available funds to meet our future operating and capital requirements will depend on many factors,
including our future sales of currently marketed products, and the potential introduction of one or more new product
candidates to the market, our business development activities, and the number, breadth and cost of our research and
development programs.
Credit Facilities & Financing Strategy
In July 2026, we entered into a $4.5 billion term loan credit agreement (the “2026 Term Loan”), which we plan to use to
finance the Crinetics Acquisition, and can be prepaid without penalty. We may also borrow up to a total of $500.0 million
pursuant to a revolving credit facility that we entered into in July 2026 (the “2026 Revolver”) and could repay and reborrow
amounts under this revolving credit agreement without penalty. Subject to certain conditions, we could request that the
borrowing capacity be increased by an additional $500.0 million, for a total of $1.0 billion. C ovenants in the 2026 Term Loan
and the 2026 Revolver could prohibit or limit our ability to access these sources of liquidity.
Future Capital Requirements
We have significant future capital requirements, including:
• We expect to acquire Crinetics in the third quarter of 2026, which we intend to fund with our cash, cash equivalents,
and proceeds from the 2026 Term Loan described above.
• Expected operating expenses to conduct research and development activities, manufacture and commercialize our
existing and future products, and to operate our organization.
• Cash that we pay for income taxes.
• Royalties we pay related to sales of our CF products.
• Facility, operating and finance lease obligations.
• Firm purchase obligations related to our supply and manufacturing processes.
In addition, other potential significant future capital requirements may include:
• We have entered into certain agreements with third parties that include the funding of certain research, development,
manufacturing and commercialization efforts. Certain of our transactions, including collaborations, licensing
arrangements, and asset acquisitions, include the potential for future milestone and royalty payments by us upon the
achievement of pre-established developmental and regulatory targets and/or commercial targets. Other transactions
include the potential for future lease-related expenses and other costs. Our obligation to fund these research and
development and commercialization efforts and to pay these potential milestones, expenses and royalties is
contingent upon continued involvement in the programs and/or the lack of any adverse events that could cause their
discontinuance. We may enter into additional agreements, including acquisitions, collaborations, licensing
arrangements and equity investments, which require additional capital.
• To the extent we borrow amounts under the 2026 Revolver, we would be required to repay any outstanding principal
amounts in July 2031.
• To the extent we borrow amounts under the 2026 Term Loan discussed above, we will be required to repay a portion
of any outstanding principal on each of the first three anniversaries from the date upon which we borrowed against
the 2026 Term Loan, including $1.0 billion on the first anniversary.

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• As of June 30, 2026 , we had $2.6 billion remaining available under the share repurchase program that our Board of
Directors authorized in May 2025. The program does not have an expiration date and can be discontinued at any
time. We expect to fund the program through a combination of cash on hand and cash generated by operations.
Other than our anticipated payment to acquire Crinetics and our entry into the 2026 Term Loan noted above, there have
not been any material changes to our future capital requirements disclosed in our Annual Report on Form 10-K for the year
ended December 31, 2025 , which was filed with the Securities and Exchange Commission, or SEC, on February 13, 2026 .
We may also raise additional capital by borrowing under credit agreements, through public offerings or private
placements of our securities, or securing new collaborative agreements or other methods of financing. We will continue to
manage our capital structure and will consider all financing opportunities, whenever they may occur, that could strengthen
our long-term liquidity profile. There can be no assurance that any such financing opportunities will be available on
acceptable terms, if at all.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES
Our discussion and analysis of our financial condition and results of operations are based upon our condensed
consolidated financial statements prepared in accordance with generally accepted accounting principles in the U.S. The
preparation of these financial statements requires us to make certain estimates and assumptions that affect the reported
amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the condensed consolidated
financial statements and the reported amounts of revenues and expenses during the reported periods. These items are
monitored and analyzed by management for changes in facts and circumstances, and material changes in these estimates
could occur in the future. Changes in estimates are reflected in reported results for the period in which the change occurs. We
base our estimates on historical experience and various other assumptions that we believe to be reasonable under the
circumstances. Actual results may differ from our estimates if past experience or other assumptions do not turn out to be
substantially accurate. During the six months ended June 30, 2026 , there were no material changes to our critical accounting
policies as reported in our Annual Report on Form 10-K for the year ended December 31, 2025 , which was filed with the
SEC on February 13, 2026 .

RECENT ACCOUNTING PRONOUNCEMENTS
For a discussion of recent accounting pronouncements, please refer to Note A, “Basis of Presentation and Accounting
Policies.”

Item 3. Quantitative and Qualitative Disclosures About Market Risk
Information required by this item is incorporated by reference from the discussion in Part II, Item 7A, “Quantitative and
Qualitative Disclosures About Market Risk,” of our Annual Report on Form 10-K for the year ended December 31, 2025 ,
which was filed with the SEC on February 13, 2026 .

Item 4. Controls and Procedures
Evaluation of Disclosure Controls and Procedures
Our management (under the supervision and with the participation of our chief executive officer and chief financial
officer), after evaluating the effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and
15d-15(e) under the Securities Exchange Act of 1934, as amended) as of the end of the period covered by this Quarterly
Report on Form 10-Q, has concluded that, based on such evaluation, as of June 30, 2026 our disclosure controls and
procedures were effective and designed to provide reasonable assurance that the information required to be disclosed is
recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms. In designing
and evaluating our disclosure controls and procedures, our management recognized that any controls and procedures, no
matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives,
and our management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible
controls and procedures.
Changes in Internal Controls Over Financial Reporting
No change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the
Securities Exchange Act of 1934, as amended) occurred during the three months ended June 30, 2026 that has materially
affected, or is reasonably likely to materially affect, our internal control over financial reporting.

PART II.  Other Informatio n

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Item 1.  Legal Proceedings
Other than as described in Part I— Note L, “Commitments and Contingencies,” to our condensed consolidated financial
statements, we are not currently subject to any material legal proceedings.

Item 1A.  Risk Factors
The information presented below supplements the risk factors set forth in Part I, Item 1A. “Risk Factors” of our Annual
Report on Form 10-K for the year ended December 31, 2025 , which was filed with the SEC on February 13, 2026 .
We may be unable to complete the Crinetics Acquisition, successfully integrate Crinetics’ business, or realize the
potential commercial benefits of the strategic acquisition, which could adversely affect our business and financial
condition.
Our inability to complete the Crinetics Acquisition or to successfully integrate the Crinetics business could have a
material adverse effect on our business . The Crinetics Acquisition may not be completed for a number of reasons, including
the need to satisfy customary closing conditions, the need for antitrust and/or other regulatory approvals, as well as potential
disputes or litigation that may arise. We provide no assurance that the Crinetics Acquisition will occur or that the closing
conditions to the Crinetics Acquisition will be satisfied in a timely manner or at all. Our realization of the value from the
Crinetics Acquisition relies on successful integration of its operations. We may not be able to integrate Crinetics’ business
successfully into our existing business, make Crinetics’ business profitable, retain key employees or realize anticipated cost
savings or synergies, if any, from the acquisition, which could adversely affect our business and financial condition. Further,
our ongoing business may be disrupted, and our management's attention may be diverted by integration activities. In addition,
the anticipated benefits of the Crinetics Acquisition depend on revenues from PALSONIFY and the commercial potential of
atumelnant. If PALSONIFY does not achieve the sales, market acceptance, or other commercial performance we expect, if
development of atumelnant is delayed or terminated, or if we fail to obtain approval or fail to successfully commercialize
atumelnant, we may not realize the expected revenue growth or income contribution from these assets on the anticipated
timeline, or at all, which could adversely affect our business and financial condition.
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report on Form 10-Q and, in particular, our Management’s Discussion and Analysis of Financial
Condition and Results of Operations set forth in Part I, Item 2, contain a number of forward-looking statements. Forward-
looking statements are not purely historical and may be accompanied by words such as “anticipates,” “may,” “forecasts,”
“expects,” “intends,” “plans,” “potentially,” “believes,” “seeks,” “estimates,” and other words and terms of similar meaning.
Such statements may relate to:
• our financial performance, including revenues, costs and expenses, taxes, and other gains and losses;
• product development, including our development timelines, timing of data from our ongoing and planned clinical
trials, regulatory authority filings and other submissions for our therapies, including the potential to file for
accelerated approvals, and communications with regulatory authorities;
• our ability to continue to grow our CF business by increasing the number of people with CF eligible and able to
receive our medicines through new approvals, label extensions and reimbursement agreements, treatment of younger
patients, increased survival, and expansion into additional geographies;
• our ability to continue to launch, commercialize and market our products, including the anticipated launch of
povetacicept for the treatment of IgAN, and our ability to obtain label expansions for existing therapies;
• our ability to obtain and maintain adequate coverage, pricing, and reimbursement from third-party payors for our
products;
• the data that will be generated by ongoing and planned clinical trials, preclinical and nonclinical studies, and the
ability to use that data to advance compounds, continue development or support regulatory filings, or accelerate
regulatory approval, including our expectations regarding the FDA’s review of our BLA for accelerated approval of
povetacicept;
• our plans to continue investing in our research and development programs, including anticipated timelines for our
programs, and our strategy to develop our pipeline programs, alone or with third party-collaborators;

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• our ability to use our research programs to identify and develop new product candidates to address serious diseases
and significant unmet medical needs;
• our beliefs regarding the approximate patient populations for the disease areas on which we focus;
• our expectations, plans and anticipated timeline for the pending Crinetics Acquisition, including regarding Crinetics’
business and operations, the commercial potential of PALSONIFY, and the anticipated potential of atumelnant and
Crinetics’ other pipeline assets;
• plans for and prospects of our business development activities, including the potential benefits and therapeutic scope
of our collaborations, our ability to integrate and continue operations of acquired businesses, and our ability to
successfully capitalize on these opportunities;
• the establishment, development and maintenance of collaborative relationships, including potential milestone
payments or other obligations, and other potential business development activities, including the identification of
potential collaborative partners or acquisition targets;
• our plans to maintain and expand our global supply chains and manufacturing infrastructure and capabilities,
including for biologics, cell and gene therapies;
• our ability to expand and protect our intellectual property portfolio and otherwise maintain exclusive rights to
products;
• our expectations or beliefs regarding any legal proceedings in which we are involved, including any litigation,
arbitration or other similar proceedings involving our products, product candidates or activities;
• potential fluctuations in foreign currency exchange rates and the effectiveness of our foreign currency management
program;
• our expectations regarding cash generated by operations, our cash balance and expected generation and net interest
income;
• our expectations regarding our provision for or benefit from income taxes and the utilization of our deferred tax
assets; and
• our liquidity and our expectations regarding the possibility of raising additional capital.
Forward-looking statements are subject to certain risks, uncertainties, or other factors that are difficult to predict and
could cause actual events or results to differ materially from those indicated in any such statements. These risks,
uncertainties, and other factors include, but are not limited to, those described in our “Risk Factors” in Item 1A of our Annual
Report on Form 10-K for the year ended December 31, 2025 , which was filed with the SEC on February 13, 2026 , and those
described from time to time in our future reports filed with the Securities and Exchange Commission.
Any such forward-looking statements are made on the basis of our views and assumptions as of the date of the filing and
are not estimates of future performance. Except as required by law, we undertake no obligation to publicly update any
forward-looking statements. The reader is cautioned not to place undue reliance on any such statements.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds
Issuer Repurchases of Equity Securities
In May 2025, our Board of Directors authorized a share repurchase program (our “Share Repurchase Program”),
pursuant to which we were authorized to repurchase up to $4.0 billion of our common stock. The Share Repurchase Program
does not have an expiration date and can be discontinued at any time.
The table set forth below shows repurchases of securities by us during the three months ended June 30, 2026 under our
Share Repurchase Program.

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Period

Total
Number
of Shares
Purchased

Average
Price
Paid per
Share

Total Number of Shares
Purchased as Part of
Publicly Announced
Plans or Programs (1)

Approximate Dollar Value
of Shares that May Yet be
Purchased Under the
Plans or Programs (1)

April 1, 2026 to April 30 , 2026

375,000

$ 436.21

375,000

$ 2,873,410,086

May 1, 2026 to May 31 , 2026

366,652

$ 434.50

366,652

$ 2,714,101,470

June 1, 2026 to June 30 , 2026

292,000

$ 452.37

292,000

$ 2,582,008,580

Total

1,033,652

$ 440.17

1,033,652

$ 2,582,008,580

(1)  Under our Share Repurchase Program, we are authorized to purchase shares from time to time through open market or privately
negotiated transactions. Such purchases may be pursuant to Rule 10b5-1 plans or other means as determined by our management and
in accordance with the requirements of the Securities and Exchange Commission.

Item 5. Other Information
Rule 10b5-1 Trading Plans
Our policy governing transactions in our securities by our directors, officers, and employees permits our officers,
directors and employees to enter into trading plans complying with Rule 10b5-1 under the Securities Exchange Act of 1934,
as amended (each a “Trading Plan”). In the second quarter of 2026 , none of our directors or officers adopted, modified or
terminated a Trading Plan.

Entry into 2026 Revolver
On July 30, 2026, we entered into a revolving credit agreement (the “2026 Revolver”), with Vertex Pharmaceuticals
(Europe) Limited, a private limited company incorporated in England and Wales and a wholly-owned subsidiary of Vertex,
as a co-borrower, Vertex Pharmaceuticals (Ireland) Limited, a private company limited by shares incorporated in Ireland and
a wholly-owned subsidiary of Vertex, as a co-borrower, certain other wholly-owned subsidiaries of Vertex party thereto as
subsidiary guarantors, the lenders and issuing banks party thereto and Bank of America, N.A., as administrative agent, which
provides for a $500 million senior unsecured revolving facility. Up to $100 million of the senior unsecured revolving facility
may be allocated for loans and letters of credit in certain non-U.S. Dollar currencies (the “ Alternative Currencies ”). The 2026
Revolver also provides that, subject to satisfaction of certain conditions, we may request that the borrowing capacity under
the 2026 Revolver be increased by an additional $500 million . Proceeds of borrowings under the 2026 Revolver will be used
for general corporate purposes. The outstanding loans under the 2026 Revolver mature, and the unused commitments
thereunder terminate, on July 30, 2031.
U.S. Dollar-denominated loans made under the 2026 Revolver will bear interest, at our option, at a rate per annum equal
to either a base rate or a SOFR-based rate, in each case, plus an applicable margin. Under the 2026 Revolver, the applicable
margin on base rate loans ranges from 0.000% to 0.500% and the applicable margin on SOFR-based loans ranges from
0.875 % to 1.500% (such margin, the “Applicable Benchmark Margin”), in each case, depending upon, either (x) Vertex’s
consolidated funded indebtedness to consolidated EBITDA ratio for the most recently completed four fiscal quarter period or
(y) to the extent available, Vertex’s credit rating. Alternative Currency-denominated loans will bear interest at a rate per
annum equal to the applicable benchmark rate for such Alternative Currency plus the Applicable Benchmark Margin. Loans
made under the 2026 Revolver may be prepaid at par and commitments under the 2026 Revolver may be reduced at any time,
in whole or in part, without premium or penalty (except for customary SOFR breakage costs).
Loans made under the 2026 Revolver will be guaranteed by certain of our existing and future domestic subsidiaries,
subject to certain customary exceptions and limitations.
The 2026 Revolver contains customary representations and warranties and affirmative and negative covenants, which
include limitations on subsidiary debt, liens and fundamental changes, as well as a financial covenant to maintain a
consolidated leverage ratio of 3.50 to 1.00, subject to an increase, at Vertex’s election, to 4.00 to 1.00 for each of the four
fiscal quarters following a material acquisition.
The 2026 Revolver also contains customary events of default. In the case of a continuing event of default, the
administrative agent would be entitled to exercise various remedies, including the acceleration of amounts due under any
outstanding loan.

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The foregoing summary of the 2026 Revolver is not complete and is qualified in its entirety by reference to the full and
complete 2026 Revolver, a copy of which will be filed with our Quarterly Report on Form 10-Q for the fiscal quarter ended
September 30, 2026.
Termination of 2022 Revolver
On July 30, 2026, we terminated and repaid all outstanding obligations under our existing credit agreement, dated as of
July 1, 2022, as amended, with certain subsidiaries party thereto as co-borrowers and/or guarantors, the lenders and issuing
banks party thereto, and Bank of America, N.A., as administrative agent (the “2022 Revolver”). In connection with the
termination of the 2022 Revolver, all guarantees thereunder were terminated and released.
Entry into 2026 Term Loan
On July 30, 2026, we entered into a t erm loan credit agreement (the “2026 Term Loan”), with certain wholly-owned
subsidiaries of Vertex party thereto as subsidiary guarantors, the lenders and issuing banks party thereto and Bank of
America, N.A., as administrative agent, which provides for a $4.5 billion senior unsecured delayed draw term loan A facility,
comprised of (a) a $1,000,000,000 tranche that will mature and be payable in full on the date that is 364 days after the date on
which the borrowing under the 2026 Term Loan is made (such date, the “Funding Date” and such loans, the “Tranche 1
Loans”), (b) a $1,000,000,000 tranche that will mature and be payable in full on the date that is two (2) years following the
Funding Date (the “Tranche 2 Loans”) and (c) a $2,500,000,000 tranche that will mature and be payable in full on the date
that is three (3) years following the Funding Date (the “Tranche 3 Loans”). Proceeds of borrowings under the 2026 Term
Loan will be used to finance in part the Crinetics Acquisition that was announced on July 6, 2026. The Funding Date under
the 2026 Term Loan is subject to the satisfaction of customary conditions, including the substantially concurrent
consummation of the Crinetics Acquisition.
Loans made under the 2026 Term Loan will bear interest, at our option, at a rate per annum equal to either a base rate or
a SOFR-based rate, in each case, plus an applicable margin. Under the 2026 Term Loan, the applicable margin on base rate
loans ranges from 0.000% to 0.500% for Tranche 1 and Tranche 2 Loans and from 0.000% to 0.625% for Tranche 3 Loans,
and the applicable margin on SOFR-based loans ranges from 0.8750% to 1.500% for Tranche 1 and Tranche 2 Loans and
from 1.000% to 1.625% for Tranche 3 Loans (such margin, the “Applicable Benchmark Margin”), in each case, depending
upon, either (x) Vertex’s consolidated funded indebtedness to consolidated EBITDA ratio for the most recently completed
four fiscal quarter period or (y) to the extent available, Vertex’s credit rating. Loans made under the 2026 Term Loan may be
prepaid at par and commitments under the 2026 Term Loan may be reduced at any time, in whole or in part, without premium
or penalty (except for customary SOFR breakage costs). There are no mandatory prepayments or amortization required in
connection with the loans made under the 2026 Term Loan.
Loans made under the 2026 Term Loan will be guaranteed by our existing and future domestic subsidiaries that
guarantee the obligations under the 2026 Revolver.
The 2026 Term Loan contains customary representations and warranties and affirmative and negative covenants, in each
case, that are substantially consistent with the representations and warranties and covenants contained in the 2026 Revolver
and which include a financial covenant to maintain a consolidated leverage ratio of 3.50 to 1.00, subject to an increase, at
Vertex’s election, to 4.00 to 1.00 for each of the four fiscal quarters following a material acquisition.
The 2026 Term Loan also contains customary events of default that are substantially consistent with the events of default
contained in the 2026 Revolver. In the case of a continuing event of default, the administrative agent would be entitled to
exercise various remedies, including the acceleration of amounts due under any outstanding loan.
The foregoing summary of the 2026 Term Loan is not complete and is qualified in its entirety by reference to the full and
complete 2026 Term Loan, a copy of which will be filed with our Quarterly Report on Form 10-Q for the fiscal quarter ended
September 30, 2026.

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Item 6. Exhibits

Exhibit
Number

Exhibit Description

2.1^

Agreement and Plan of Merger by and among Crinetics Pharmaceuticals, Inc., Vertex Pharmaceuticals Incorporated, and Clark Merger
Sub, Inc. dated July 6, 2026 (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed with the Securities and
Exchange Commission by Crinetics Pharmaceuticals, Inc. on July 6, 2026).

10.1

Vertex Pharmaceuticals Incorporated 2026 Stock and Option Plan dated (incorporated by reference to Exhibit 99.1 to the Registration
Statement on Form S-8 filed with the Securities and Exchange Commission by Vertex Pharmaceuticals Incorporated on May 13, 2026).*

10.2

Form of Restricted Stock Unit Agreement under the 2026 Stock and Option Plan.*

10.3

Form of Restricted Stock Unit Agreement (with Performance Conditions) under the 2026 Stock and Option Plan.*

10.4

Form of Restricted Stock Unit Agreement (for Non-Employee Directors) under the 2026 Stock and Option Plan.*

10.5

Form of Option Agreement (for Non-Employee Directors) under the 2026 Stock and Option Plan.*

10.6

Non-Employee Director Deferred Compensation Plan.*

31.1

Certification of the Chief Executive Officer under Section 302 of the Sarbanes-Oxley Act of 2002.

31.2

Certification of the Chief Financial Officer under Section 302 of the Sarbanes-Oxley Act of 2002.

32.1

Certification of the Chief Executive Officer and the Chief Financial Officer under Section 906 of the Sarbanes-Oxley Act of 2002.

101.INS

XBRL Instance - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline
XBRL document.

101.SCH

XBRL Taxonomy Extension Schema

101.CAL

XBRL Taxonomy Extension Calculation

101.LAB

XBRL Taxonomy Extension Labels

101.PRE

XBRL Taxonomy Extension Presentation

101.DEF

XBRL Taxonomy Extension Definition

104

Cover Page Interactive Data File––the cover page interactive data file does not appear in the Interactive Data File because its XBRL tags
are embedded within the Inline XBRL document.

^

Schedules and similar attachments have been omitted pursuant to Item 601(a)(5) of Regulation S-K. A copy of any omitted schedule will
be furnished supplementally to the SEC upon request.

*

Management contract, compensatory plan or agreement.

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be
signed on its behalf by the undersigned thereunto duly authorized.

Vertex Pharmaceuticals Incorporated

August 4, 2026

By:

/s/ Charles F. Wagner, Jr.

Charles F. Wagner, Jr.

Executive Vice President, Chief Operating & Financial Officer
(principal financial officer and
duly authorized officer)